PMID Title Journal Publication Year Author View in RVdb
10098667 Design, synthesis, and evaluation of azapeptides as substrates and inhibitors for human rhinovirus 3C protease. Bioorg Med Chem Lett 1999 Venkatraman S;Kong J;Nimkar S;Wang QM;Aube J;Hanzlik RP View More
10103186 Antiviral effect of hyperthermic treatment in rhinovirus infection. Antimicrob Agents Chemother 1999 Conti C;De Marco A;Mastromarino P;Tomao P;Santoro MG View More
10197964 Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 3. Structure-activity studies of ketomethylene-containing peptidomimetics. J Med Chem 1999 Dragovich PS;Prins TJ;Zhou R;Fuhrman SA;Patick AK;Matthews DA;Ford CE;Meador JW 3rd;Ferre RA;Worland ST View More
10197965 Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 4. Incorporation of P1 lactam moieties as L-glutamine replacements. J Med Chem 1999 Dragovich PS;Prins TJ;Zhou R;Webber SE;Marakovits JT;Fuhrman SA;Patick AK;Matthews DA;Lee CA;Ford CE;Burke BJ;Rejto PA;Hendrickson TF;Tuntland T;Brown EL;Meador JW 3rd;Ferre RA;Harr JE;Kosa MB;Worland ST View More
10224078 Identification and characterization of human rhinovirus-14 3C protease deamidation isoform. J Biol Chem 1999 Cox GA;Johnson RB;Cook JA;Wakulchik M;Johnson MG;Villarreal EC;Wang QM View More
10353638 Solid-phase synthesis of irreversible human rhinovirus 3C protease inhibitors. Part 1: Optimization of tripeptides incorporating N-terminal amides. Bioorg Med Chem 1999 Dragovich PS;Zhou R;Skalitzky DJ;Fuhrman SA;Patick AK;Ford CE;Meador JW 3rd;Worland ST View More
10396129 Protease inhibitors as potential antiviral agents for the treatment of picornaviral infections. Prog Drug Res 1999 Wang QM View More
10465543 Structure-based design of irreversible, tripeptidyl human rhinovirus 3C protease inhibitors containing N-methyl amino acids. Bioorg Med Chem Lett 1999 Dragovich PS;Webber SE;Prins TJ;Zhou R;Marakovits JT;Tikhe JG;Fuhrman SA;Patick AK;Matthews DA;Ford CE;Brown EL;Binford SL;Meador JW 3rd;Ferre RA;Worland ST View More
10500114 Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes. Proc Natl Acad Sci U S A 1999 Matthews DA;Dragovich PS;Webber SE;Fuhrman SA;Patick AK;Zalman LS;Hendrickson TF;Love RA;Prins TJ;Marakovits JT;Zhou R;Tikhe J;Ford CE;Meador JW;Ferre RA;Brown EL;Binford SL;Brothers MA;DeLisle DM;Worland ST View More
10507322 Rhinovirus 2A proteinase mediated stimulation of rhinovirus RNA translation is additive to the stimulation effected by cellular RNA binding proteins. Virus Res 1999 Hunt SL;Skern T;Liebig HD;Kuechler E;Jackson RJ View More
10507325 The structures of picornaviral proteinases. Virus Res 1999 Seipelt J;Guarne A;Bergmann E;James M;Sommergruber W;Fita I;Skern T View More
10508022 In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease. Antimicrob Agents Chemother 1999 Patick AK;Binford SL;Brothers MA;Jackson RL;Ford CE;Diem MD;Maldonado F;Dragovich PS;Zhou R;Prins TJ;Fuhrman SA;Meador JW;Zalman LS;Matthews DA;Worland ST View More
10523291 The structure of the 2A proteinase from a common cold virus: a proteinase responsible for the shut-off of host-cell protein synthesis. EMBO J 1999 Petersen JF;Cherney MM;Liebig HD;Skern T;Kuechler E;James MN View More
10595531 Molecular dynamics investigation of the effect of an antiviral compound on human rhinovirus. Protein Sci 1999 Phelps DK;Post CB View More
10600561 Review: rhinoviruses and their ICAM receptors. J Struct Biol 1999 Bella J;Rossmann MG View More
10636240 Structure-based design of ketone-containing, tripeptidyl human rhinovirus 3C protease inhibitors. Bioorg Med Chem Lett 2000 Dragovich PS;Zhou R;Webber SE;Prins TJ;Kwok AK;Okano K;Fuhrman SA;Zalman LS;Maldonado FC;Brown EL;Meador JW 3rd;Patick AK;Ford CE;Brothers MA;Binford SL;Matthews DA;Ferre RA;Worland ST View More
10640559 The 2A proteins of three diverse picornaviruses are related to each other and to the H-rev107 family of proteins involved in the control of cell proliferation. J Gen Virol 2000 Hughes PJ;Stanway G View More
10680117 A homology modeling method of an icosahedral viral capsid: inclusion of surrounding protein structures. J Mol Graph Model 1999 Yoneda T;Yoneda S;Takayama N;Kitazawa M;Umeyama H View More
10709092 Human retrovirus 5 sequences in peripheral blood cells of patients with B-cell non-Hodgkin\'s lymphoma. Int J Cancer 2000 Murovska M;Lejniece S;Kozireva S;Koulikovska M;Yin H;Blomberg J View More
10770757 Inhibition of human rhinovirus-induced cytokine production by AG7088, a human rhinovirus 3C protease inhibitor. Antimicrob Agents Chemother 2000 Zalman LS;Brothers MA;Dragovich PS;Zhou R;Prins TJ;Worland ST;Patick AK View More
10794684 Substituted benzamide inhibitors of human rhinovirus 3C protease: structure-based design, synthesis, and biological evaluation. J Med Chem 2000 Reich SH;Johnson T;Wallace MB;Kephart SE;Fuhrman SA;Worland ST;Matthews DA;Hendrickson TF;Chan F;Meador J 3rd;Ferre RA;Brown EL;DeLisle DM;Patick AK;Binford SL;Ford CE View More
10867028 2A proteinase of human rhinovirus cleaves cytokeratin 8 in infected HeLa cells. J Biol Chem 2000 Seipelt J;Liebig HD;Sommergruber W;Gerner C;Kuechler E View More
10903863 Structure of human rhinovirus serotype 2 (HRV2). J Mol Biol 2000 Verdaguer N;Blaas D;Fita I View More
10950388 Antiviral therapy for enteroviruses and rhinoviruses. Antivir Chem Chemother 2000 Rotbart HA View More
10999479 S-nitrosothiols as novel, reversible inhibitors of human rhinovirus 3C protease. Bioorg Med Chem Lett 2000 Xian M;Wang QM;Chen X;Wang K;Wang PG View More
11007981 Characterization of the active site thiol group of rhinovirus 2A proteinase. FEBS Lett 2000 Sarkany Z;Skern T;Polgar L View More
11034318 Extremely efficient cleavage of eIF4G by picornaviral proteinases L and 2A in vitro. FEBS Lett 2000 Glaser W;Skern T View More
11118371 Complete nucleotide sequence of the chiba virus genome and functional expression of the 3C-like protease in Escherichia coli. Virology 2000 Someya Y;Takeda N;Miyamura T View More
11119599 The E1 initiator recognizes multiple overlapping sites in the papillomavirus origin of DNA replication. J Virol 2001 Chen G;Stenlund A View More
11161279 The C-terminal residues of poliovirus proteinase 2A(pro) are critical for viral RNA replication but not for cis- or trans-proteolytic cleavage. J Gen Virol 2001 Li X;Lu HH;Mueller S;Wimmer E View More
11162821 Activation of human rhinovirus-14 3C protease. Virology 2001 Wang QM;Johnson RB View More
11166856 The treatment of rhinovirus infections: progress and potential. Antiviral Res 2001 Turner RB View More
11274152 Disruption of the interaction of mammalian protein synthesis eukaryotic initiation factor 4B with the poly(A)-binding protein by caspase- and viral protease-mediated cleavages. J Biol Chem 2001 Bushell M;Wood W;Carpenter G;Pain VM;Morley SJ;Clemens MJ View More
11277694 Membrane-associated respiratory syncytial virus F protein expressed from a human rhinovirus type 14 vector is immunogenic. Virology 2001 Dollenmaier G;Mosier SM;Scholle F;Sharma N;McKnight KL;Lemon SM View More
11297676 Analysis of the aphthovirus 2A/2B polyprotein \'cleavage\' mechanism indicates not a proteolytic reaction, but a novel translational effect: a putative ribosomal \'skip\'. J Gen Virol 2001 Donnelly MLL;Luke G;Mehrotra A;Li X;Hughes LE;Gani D;Ryan MD View More
11302940 Liquid chromatography-mass spectrometry and liquid chromatography-NMR characterization of in vitro metabolites of a potent and irreversible peptidomimetic inhibitor of rhinovirus 3C protease. Drug Metab Dispos 2001 Zhang KE;Hee B;Lee CA;Liang B;Potts BC View More
11378491 Rapid multiserotype detection of human rhinoviruses on optically coated silicon surfaces. J Clin Virol 2001 Ostroff R;Ettinger A;La H;Rihanek M;Zalman L;Meador J 3rd;Patick AK;Worland S;Polisky B View More
11414203 MBP fusion protein with a viral protease cleavage site: one-step cleavage/purification of insoluble proteins. Biotechniques 2001 Alexandrov A;Dutta K;Pascal SM View More
11461680 Human retrovirus type 5 sequences in non-Hodgkin\'s lymphoma of T cell origin. AIDS Res Hum Retroviruses 2001 Kozireva S;Lejniece S;Blomberg J;Murovska M View More
11473996 Antibody-secreting cell responses to rotavirus proteins in gnotobiotic pigs inoculated with attenuated or virulent human rotavirus. J Clin Microbiol 2001 Chang KO;Vandal OH;Yuan L;Hodgins DC;Saif LJ View More
11533189 Evidence that Equine rhinitis A virus VP1 is a target of neutralizing antibodies and participates directly in receptor binding. J Virol 2001 Warner S;Hartley CA;Stevenson RA;Ficorilli N;Varrasso A;Studdert MJ;Crabb BS View More
11548209 Protease inhibitors as potential antiviral agents for the treatment of picornaviral infections. Prog Drug Res 2001 Wang QM View More
11591501 Design and synthesis of irreversible depsipeptidyl human rhinovirus 3C protease inhibitors. Bioorg Med Chem Lett 2001 Webber SE;Marakovits JT;Dragovich PS;Prins TJ;Zhou R;Fuhrman SA;Patick AK;Matthews DA;Lee CA;Srinivasan B;Moran T;Ford CE;Brothers MA;Harr JE;Meador JW 3rd;Ferre RA;Worland ST View More
11602737 Biochemical and genetic studies of the initiation of human rhinovirus 2 RNA replication: purification and enzymatic analysis of the RNA-dependent RNA polymerase 3D(pol). J Virol 2001 Gerber K;Wimmer E;Paul AV View More
11602738 Biochemical and genetic studies of the initiation of human rhinovirus 2 RNA replication: identification of a cis-replicating element in the coding sequence of 2A(pro). J Virol 2001 Gerber K;Wimmer E;Paul AV View More
11720861 Discovery, total synthesis, HRV 3C-protease inhibitory activity, and structure-activity relationships of 2-methoxystypandrone and its analogues. Bioorg Med Chem Lett 2001 Singh SB;Graham PL;Reamer RA;Cordingley MG View More
11764773 Recent advances in the treatment of rhinovirus infections. Curr Opin Pharmacol 2001 McKinlay MA View More
11858991 Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. Part 7: structure-activity studies of bicyclic 2-pyridone-containing peptidomimetics. Bioorg Med Chem Lett 2002 Dragovich PS;Prins TJ;Zhou R;Johnson TO;Brown EL;Maldonado FC;Fuhrman SA;Zalman LS;Patick AK;Matthews DA;Hou X;Meador JW;Ferre RA;Worland ST View More
11900346 Peptidyl diazomethyl ketones inhibit the human rhinovirus 3C protease: effect on virus yield by partial block of P3 polyprotein processing. Antivir Chem Chemother 2001 Murray MA;Janc JW;Venkatraman S;Babe LM View More
11911365 Determinants of the recognition of enteroviral cloverleaf RNA by coxsackievirus B3 proteinase 3C. RNA 2002 Zell R;Sidigi K;Bucci E;Stelzner A;Gorlach M View More
11931615 Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 6. Structure-activity studies of orally bioavailable, 2-pyridone-containing peptidomimetics. J Med Chem 2002 Dragovich PS;Prins TJ;Zhou R;Brown EL;Maldonado FC;Fuhrman SA;Zalman LS;Tuntland T;Lee CA;Patick AK;Matthews DA;Hendrickson TF;Kosa MB;Liu B;Batugo MR;Gleeson JP;Sakata SK;Chen L;Guzman MC;Meador JW 3rd;Ferre RA;Worland ST View More
11985469 Structure-based design of a parallel synthetic array directed toward the discovery of irreversible inhibitors of human rhinovirus 3C protease. J Med Chem 2002 Johnson TO;Hua Y;Luu HT;Brown EL;Chan F;Chu SS;Dragovich PS;Eastman BW;Ferre RA;Fuhrman SA;Hendrickson TF;Maldonado FC;Matthews DA;Meador JW 3rd;Patick AK;Reich SH;Skalitzky DJ;Worland ST;Yang M;Zalman LS View More
12133721 Recent advances in the synthesis, design and selection of cysteine protease inhibitors. Curr Opin Chem Biol 2002 Hernandez AA;Roush WR View More
12191477 The concerted conformational changes during human rhinovirus 2 uncoating. Mol Cell 2002 Hewat EA;Neumann E;Blaas D View More
12370317 Sequential and ordered assembly of E1 initiator complexes on the papillomavirus origin of DNA replication generates progressive structural changes related to melting. Mol Cell Biol 2002 Chen G;Stenlund A View More
12409401 Human rhinovirus 87 and enterovirus 68 represent a unique serotype with rhinovirus and enterovirus features. J Clin Microbiol 2002 Blomqvist S;Savolainen C;Raman L;Roivainen M;Hovi T View More
12525179 The unusual catalytic triad of poliovirus protease 3C. Biochemistry 2003 Sarkany Z;Polgar L View More
12663811 The processing of eIF4GI by human rhinovirus type 2 2A(pro): relationship to self-cleavage and role of zinc. J Virol 2003 Glaser W;Triendl A;Skern T View More
12663812 Human rhinovirus 2A proteinase cleavage sites in eukaryotic initiation factors (eIF) 4GI and eIF4GII are different. J Virol 2003 Gradi A;Svitkin YV;Sommergruber W;Imataka H;Morino S;Skern T;Sonenberg N View More
12743280 Human rhinovirus type 16: mutant V1210A requires capsid-binding drug for assembly of pentamers to form virions during morphogenesis. J Virol 2003 Lee WM;Wang W View More
12766405 Backbone 1H, 15N and 13C assignments for the human rhinovirus 3C protease (serotype 14). J Biomol NMR 2003 Bjorndahl TC;Monzavi H;Wishart DS View More
12768011 Sequence and structure of human rhinoviruses reveal the basis of receptor discrimination. J Virol 2003 Vlasak M;Blomqvist S;Hovi T;Hewat E;Blaas D View More
12857919 A cellular receptor of human rhinovirus type 2, the very-low-density lipoprotein receptor, binds to two neighboring proteins of the viral capsid. J Virol 2003 Neumann E;Moser R;Snyers L;Blaas D;Hewat EA View More
12921996 Encephalomyocarditis virus (EMCV) proteins 2A and 3BCD localize to nuclei and inhibit cellular mRNA transcription but not rRNA transcription. Virus Res 2003 Aminev AG;Amineva SP;Palmenberg AC View More
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1317152 Mechanism of action of the antirhinovirus flavanoid 4\',6-dicyanoflavan. Antimicrob Agents Chemother 1992 Conti C;Tomao P;Genovese D;Desideri N;Stein ML;Orsi N View More
1318383 Binding of an antiviral agent to a sensitive and a resistant human rhinovirus. Computer simulation studies with sampling of amino acid side-chain conformation. I. Mapping the rotamers of residue 188 of viral protein 1. J Mol Biol 1992 Wade RC;McCammon JA View More
1318384 Binding of an antiviral agent to a sensitive and a resistant human rhinovirus. Computer simulation studies with sampling of amino acid side-chain conformations. II. Calculation of free-energy differences by thermodynamic integration. J Mol Biol 1992 Wade RC;McCammon JA View More
1325156 Using proteinase trapping to detect revertants of inactive rhinoviral 2A proteinase mutants. Biol Chem Hoppe Seyler 1992 Luderer M;Liebig HD;Sommergruber W;Blaas D;Kuechler E;Skern T View More
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14505664 Synthesis and evaluation of tripeptidyl alpha-ketoamides as human rhinovirus 3C protease inhibitors. Bioorg Med Chem Lett 2003 Chen SH;Lamar J;Victor F;Snyder N;Johnson R;Heinz BA;Wakulchik M;Wang QM View More
14521419 Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 8. Pharmacological optimization of orally bioavailable 2-pyridone-containing peptidomimetics. J Med Chem 2003 Dragovich PS;Prins TJ;Zhou R;Johnson TO;Hua Y;Luu HT;Sakata SK;Brown EL;Maldonado FC;Tuntland T;Lee CA;Fuhrman SA;Zalman LS;Patick AK;Matthews DA;Wu EY;Guo M;Borer BC;Nayyar NK;Moran T;Chen L;Rejto PA;Rose PW;Guzman MC;Dovalsantos EZ;Lee S;McGee K;Mohajeri M;Liese A;Tao J;Kosa MB;Liu B;Batugo MR;Gleeson JP;Wu ZP;Liu J;Meador JW 3rd;Ferre RA View More
14605258 Rhinovirus 16 3C protease induces interleukin-8 and granulocyte-macrophage colony-stimulating factor expression in human bronchial epithelial cells. Pediatr Res 2004 Funkhouser AW;Kang JA;Tan A;Li J;Zhou L;Abe MK;Solway J;Hershenson MB View More
14711816 Genetic evidence for an interaction between a picornaviral cis-acting RNA replication element and 3CD protein. J Biol Chem 2004 Yang Y;Rijnbrand R;Watowich S;Lemon SM View More
14748074 Simultaneous detection of fourteen respiratory viruses in clinical specimens by two multiplex reverse transcription nested-PCR assays. J Med Virol 2004 Coiras MT;Aguilar JC;Garcia ML;Casas I;Perez-Brena P View More
15016887 VP1 sequencing of all human rhinovirus serotypes: insights into genus phylogeny and susceptibility to antiviral capsid-binding compounds. J Virol 2004 Ledford RM;Patel NR;Demenczuk TM;Watanyar A;Herbertz T;Collett MS;Pevear DC View More
15080921 Exploring the binding mechanism of the main proteinase in SARS-associated coronavirus and its implication to anti-SARS drug design. Bioorg Med Chem 2004 Zhang XW;Yap YL View More
15158778 Regulation of picornavirus gene expression. Microbes Infect 2004 Bedard KM;Semler BL View More
15168795 An optical thin film assay incorporating rhinovirus protease inhibitors as detector reagents. Antiviral Res 2004 Ettinger A;Ostroff R;Rhihanek M;Dragovich PS;Zalman LS;Patick AK;Prins TJ;Fuhrman SA;Brown EL;Worland ST;Polisky B View More
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15331736 Discrimination among rhinovirus serotypes for a variant ICAM-1 receptor molecule. J Virol 2004 Xiao C;Tuthill TJ;Bator Kelly CM;Challinor LJ;Chipman PR;Killington RA;Rowlands DJ;Craig A;Rossmann MG View More
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15648087 Biopolymer stochastic moments. I. Modeling human rhinovirus cellular recognition with protein surface electrostatic moments. Biopolymers 2005 Gonzalez-Diaz H;Uriarte E View More
15673742 Conservation of amino acids in human rhinovirus 3C protease correlates with broad-spectrum antiviral activity of rupintrivir, a novel human rhinovirus 3C protease inhibitor. Antimicrob Agents Chemother 2005 Binford SL;Maldonado F;Brothers MA;Weady PT;Zalman LS;Meador JW 3rd;Matthews DA;Patick AK View More
15722530 Phylogenetic analysis of human rhinovirus capsid protein VP1 and 2A protease coding sequences confirms shared genus-like relationships with human enteroviruses. J Gen Virol 2005 Laine P;Savolainen C;Blomqvist S;Hovi T View More
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15917520 In vitro antiviral activity and single-dose pharmacokinetics in humans of a novel, orally bioavailable inhibitor of human rhinovirus 3C protease. Antimicrob Agents Chemother 2005 Patick AK;Brothers MA;Maldonado F;Binford S;Maldonado O;Fuhrman S;Petersen A;Smith GJ 3rd;Zalman LS;Burns-Naas LA;Tran JQ View More
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