| Title | Design, synthesis, and evaluation of azapeptides as substrates and inhibitors for human rhinovirus 3C protease. | ||
| Author | Venkatraman, S; Kong, J; Nimkar, S; Wang, Q M; Aube, J; Hanzlik, R P | ||
| Journal | Bioorg Med Chem Lett | Publication Year/Month | 1999-Feb |
| PMID | 10098667 | PMCID | -N/A- |
| Affiliation | 1.Department of Medicinal Chemistry, The University of Kansas, Lawrence 66045-2506, USA. | ||
A series of azapeptides was prepared and assessed as inhibitors of the human rhinovirus 3C protease. Boc-VLFaQ-OPh was a slow-turnover substrate that gave transient (ca. 1-2 h) inhibition as it underwent hydrolysis. Boc-VLFaG-OPh gave very slow but essentially irreversible inhibition.