| Title | Synthesis and evaluation of 9-deoxy analogues of (-)-thysanone, an inhibitor of HRV 3C protease. | ||
| Author | Young Jeong, Joo; Sperry, Jonathan; Taylor, John A; Brimble, Margaret A | ||
| Journal | Eur J Med Chem | Publication Year/Month | 2014-Nov |
| PMID | 25259514 | PMCID | -N/A- |
| Affiliation + expend | 1.School of Chemical Sciences, The University of Auckland, 23 Symonds St., Auckland 1142, New Zealand; School of Biological Sciences, The University of Auckland, 3A Symonds St., Auckland 1010, New Zealand. | ||
9-Deoxy analogues of the HRV 3C protease inhibitor (-)-thysanone display better inhibitory properties than the natural product, inferring the C9-OH hinders binding to the enzyme.