| Title | Pharmacophore-based design, synthesis, and biological evaluation of novel chloro-pyridazine piperazines as human rhinovirus (HRV-3) inhibitors. | ||
| Author | Wang, Hongliang; Xiao, Junhai; Gao, Dapeng; Zhang, Xian; Yan, Hui; Gong, Zehui; Sun, Tinmin; Li, Song | ||
| Journal | Bioorg Med Chem Lett | Publication Year/Month | 2011-Feb |
| PMID | 21215622 | PMCID | -N/A- |
| Affiliation | 1.Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, PR China. | ||
A series of chloro-pyridazine piperazines were developed based on the structure of human rhinovirus (HRV) capsid-binding inhibitors with proven activity using a pharmacophore model. A preliminary evaluation demonstrated potent activity against HRV-3 with low cytotoxicity. A docking analysis indicated that 8a could fit into, and form tight interactions (e.g., H-bonds, sigma-pi effect) with the active site in VP1.