| Title | Structure and inhibition of EV-D68, a virus that causes respiratory illness in children. | ||
| Author | Liu, Yue; Sheng, Ju; Fokine, Andrei; Meng, Geng; Shin, Woong-Hee; Long, Feng; Kuhn, Richard J; Kihara, Daisuke; Rossmann, Michael G | ||
| Journal | Science | Publication Year/Month | 2015-Jan |
| PMID | 25554786 | PMCID | PMC4307789 |
| Affiliation + expend | 1.Department of Biological Sciences, Hockmeyer Hall of Structural Biology, 240 South Martin Jischke Drive, Purdue University, West Lafayette, IN 47907, USA. | ||
Enterovirus D68 (EV-D68) is a member of Picornaviridae and is a causative agent of recent outbreaks of respiratory illness in children in the United States. We report here the crystal structures of EV-D68 and its complex with pleconaril, a capsid-binding compound that had been developed as an anti-rhinovirus drug. The hydrophobic drug-binding pocket in viral protein 1 contained density that is consistent with a fatty acid of about 10 carbon atoms. This density could be displaced by pleconaril. We also showed that pleconaril inhibits EV-D68 at a half-maximal effective concentration of 430 nanomolar and might, therefore, be a possible drug candidate to alleviate EV-D68 outbreaks.