| Title | Stabilization of human rhinovirus serotype 2 against pH-induced conformational change by antiviral compounds. | ||
| Author | Gruenberger, M; Pevear, D; Diana, G D; Kuechler, E; Blaas, D | ||
| Journal | J Gen Virol | Publication Year/Month | 1991-Feb |
| PMID | 1847178 | PMCID | -N/A- |
| Affiliation | 1.Institute of Biochemistry, University of Vienna, Austria. | ||
Four WIN compounds with anti-picornavirus activities were tested for their ability to stabilize human rhinovirus serotype 2 (HRV-2) against low pH-induced conformational changes in vitro, as determined by specific immunoprecipitation. These results were compared to the minimal inhibitory concentration (MIC) as measured in a plaque reduction assay. A direct relationship was observed between the concentration of the compound that prevented the low pH-induced conformational changes and the MIC, indicating that stabilization is an important element in the mode of action of these drugs against HRV-2.