| Title | Synthesis and evaluation of tripeptidyl alpha-ketoamides as human rhinovirus 3C protease inhibitors. | ||
| Author | Chen, Shu-Hui; Lamar, Jason; Victor, Frantz; Snyder, Nancy; Johnson, Robert; Heinz, Beverly A; Wakulchik, Mark; Wang, Q May | ||
| Journal | Bioorg Med Chem Lett | Publication Year/Month | 2003-Oct |
| PMID | 14505664 | PMCID | -N/A- |
| Affiliation | 1.Discovery Chemistry Research and Technology, Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA. chen_shu-hui@lilly.com. | ||
We describe herein the synthesis and biological evaluation of a series of tripeptidyl alpha-ketoamides as human rhinovirus (HRV) 3C protease inhibitors. The most potent inhibitor discussed in this manuscript, 4I, exhibited impressive enzyme inhibitory activity as well as antiviral activity against HRV-14.