| Title | Human rhinovirus 2A proteinase cleavage sites in eukaryotic initiation factors (eIF) 4GI and eIF4GII are different. | ||
| Author | Gradi, Alessandra; Svitkin, Yuri V; Sommergruber, Wolfgang; Imataka, Hiroaki; Morino, Shigenobu; Skern, Tim; Sonenberg, Nahum | ||
| Journal | J Virol | Publication Year/Month | 2003-Apr |
| PMID | 12663812 | PMCID | PMC152112 |
| Affiliation | 1.Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, Canada H3G 1Y6. | ||
Several picornaviruses shut down host cellular protein synthesis by proteolytic cleavage of the eukaryotic initiation factor (eIF) 4GI and eIF4GII isoforms. Viral RNA translation is maintained by a cap-independent mechanism. Here, we identify the human rhinovirus 2 2A(pro) cleavage site in eIF4GII in vitro as PLLNV(699)*GSR; this sequence lies seven amino acids C-terminal to the cleavage site previously identified in eIF4GI (LSTR681*GPP).