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Pan-3C Protease Inhibitor Rupintrivir Binds SARS-CoV-2 Main Protease in a Unique Binding Mode. |
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Poliovirus protease 3C mediates cleavage of microtubule-associated protein 4. |
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Mapping the cleavage site in protein synthesis initiation factor eIF-4 gamma of the 2A proteases from human Coxsackievirus and rhinovirus. |
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Spectroscopic characterization of rhinoviral protease 2A: Zn is essential for the structural integrity. |
Protein Sci |
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Proteolytically active 2A proteinase of human rhinovirus 2 is toxic for Saccharomyces cerevisiae but does not cleave the homologues of eIF-4 gamma in vivo or in vitro. |
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Human rhinovirus 2A proteinase mutant and its second-site revertants. |
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Simple in vitro translation assay to analyze inhibitors of rhinovirus proteases. |
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A single amino acid change in protein synthesis initiation factor 4G renders cap-dependent translation resistant to picornaviral 2A proteases. |
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The eIF4G-eIF4E complex is the target for direct cleavage by the rhinovirus 2A proteinase. |
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Mengo virus 3C proteinase: recombinant expression, intergenus substrate cleavage and localization in vivo. |
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Design, synthesis, and evaluation of nonpeptidic inhibitors of human rhinovirus 3C protease. |
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Comparison of picornaviral IRES-driven internal initiation of translation in cultured cells of different origins. |
Nucleic Acids Res |
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Cleavage specificity of human rhinovirus-2 2A protease for peptide substrates. |
Biochem Biophys Res Commun |
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Wang QM;Sommergruber W;Johnson RB |
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Mutational analyses support a model for the HRV2 2A proteinase. |
Virology |
1997 |
Sommergruber W;Seipelt J;Fessl F;Skern T;Liebig HD;Casari G |
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Expression and purification of recombinant rhinovirus 14 3CD proteinase and its comparison to the 3C proteinase. |
Arch Biochem Biophys |
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A continuous colorimetric assay for rhinovirus-14 3C protease using peptide p-nitroanilides as substrates. |
Anal Biochem |
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Enzymatic characterization of refolded human rhinovirus type 14 2A protease expressed in Escherichia coli. |
J Virol |
1998 |
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A structural model of picornavirus leader proteinases based on papain and bleomycin hydrolase. |
J Gen Virol |
1998 |
Skern T;Fita I;Guarne A |
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The predominant elF4G-specific cleavage activity in poliovirus-infected HeLa cells is distinct from 2A protease. |
Virology |
1998 |
Bovee ML;Marissen WE;Zamora M;Lloyd RE |
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Direct cleavage of elF4G by poliovirus 2A protease is inefficient in vitro. |
Virology |
1998 |
Bovee ML;Lamphear BJ;Rhoads RE;Lloyd RE |
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Synthesis and evaluation of peptidyl Michael acceptors that inactivate human rhinovirus 3C protease and inhibit virus replication. |
J Med Chem |
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Tripeptide aldehyde inhibitors of human rhinovirus 3C protease: design, synthesis, biological evaluation, and cocrystal structure solution of P1 glutamine isosteric replacements. |
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Webber SE;Okano K;Little TL;Reich SH;Xin Y;Fuhrman SA;Matthews DA;Love RA;Hendrickson TF;Patick AK;Meador JW 3rd;Ferre RA;Brown EL;Ford CE;Binford SL;Worland ST |
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Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 1. Michael acceptor structure-activity studies. |
J Med Chem |
1998 |
Dragovich PS;Webber SE;Babine RE;Fuhrman SA;Patick AK;Matthews DA;Lee CA;Reich SH;Prins TJ;Marakovits JT;Littlefield ES;Zhou R;Tikhe J;Ford CE;Wallace MB;Meador JW 3rd;Ferre RA;Brown EL;Binford SL;Harr JE;DeLisle DM;Worland ST |
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Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 2. Peptide structure-activity studies. |
J Med Chem |
1998 |
Dragovich PS;Webber SE;Babine RE;Fuhrman SA;Patick AK;Matthews DA;Reich SH;Marakovits JT;Prins TJ;Zhou R;Tikhe J;Littlefield ES;Bleckman TM;Wallace MB;Little TL;Ford CE;Meador JW 3rd;Ferre RA;Brown EL;Binford SL;DeLisle DM;Worland ST |
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Development of in vitro peptide substrates for human rhinovirus-14 2A protease. |
Arch Biochem Biophys |
1998 |
Wang QM;Johnson RB;Sommergruber W;Shepherd TA |
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Poliovirus 2A proteinase cleaves directly the eIF-4G subunit of eIF-4F complex. |
FEBS Lett |
1998 |
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Cleavage of Poly(A)-binding protein by coxsackievirus 2A protease in vitro and in vivo: another mechanism for host protein synthesis shutoff? |
J Virol |
1999 |
Kerekatte V;Keiper BD;Badorff C;Cai A;Knowlton KU;Rhoads RE |
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The role of oxidative stress in rhinovirus induced elaboration of IL-8 by respiratory epithelial cells. |
Free Radic Biol Med |
1999 |
Biagioli MC;Kaul P;Singh I;Turner RB |
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Inhibition of 3C protease from human rhinovirus strain 1B by peptidyl bromomethylketonehydrazides. |
Arch Biochem Biophys |
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