PMID Title Journal Publication Year Author View in RVdb
10098667 Design, synthesis, and evaluation of azapeptides as substrates and inhibitors for human rhinovirus 3C protease. Bioorg Med Chem Lett 1999 Venkatraman S;Kong J;Nimkar S;Wang QM;Aube J;Hanzlik RP View More
10197964 Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 3. Structure-activity studies of ketomethylene-containing peptidomimetics. J Med Chem 1999 Dragovich PS;Prins TJ;Zhou R;Fuhrman SA;Patick AK;Matthews DA;Ford CE;Meador JW 3rd;Ferre RA;Worland ST View More
10197965 Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 4. Incorporation of P1 lactam moieties as L-glutamine replacements. J Med Chem 1999 Dragovich PS;Prins TJ;Zhou R;Webber SE;Marakovits JT;Fuhrman SA;Patick AK;Matthews DA;Lee CA;Ford CE;Burke BJ;Rejto PA;Hendrickson TF;Tuntland T;Brown EL;Meador JW 3rd;Ferre RA;Harr JE;Kosa MB;Worland ST View More
10224078 Identification and characterization of human rhinovirus-14 3C protease deamidation isoform. J Biol Chem 1999 Cox GA;Johnson RB;Cook JA;Wakulchik M;Johnson MG;Villarreal EC;Wang QM View More
10353638 Solid-phase synthesis of irreversible human rhinovirus 3C protease inhibitors. Part 1: Optimization of tripeptides incorporating N-terminal amides. Bioorg Med Chem 1999 Dragovich PS;Zhou R;Skalitzky DJ;Fuhrman SA;Patick AK;Ford CE;Meador JW 3rd;Worland ST View More
10396129 Protease inhibitors as potential antiviral agents for the treatment of picornaviral infections. Prog Drug Res 1999 Wang QM View More
10465543 Structure-based design of irreversible, tripeptidyl human rhinovirus 3C protease inhibitors containing N-methyl amino acids. Bioorg Med Chem Lett 1999 Dragovich PS;Webber SE;Prins TJ;Zhou R;Marakovits JT;Tikhe JG;Fuhrman SA;Patick AK;Matthews DA;Ford CE;Brown EL;Binford SL;Meador JW 3rd;Ferre RA;Worland ST View More
10500114 Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes. Proc Natl Acad Sci U S A 1999 Matthews DA;Dragovich PS;Webber SE;Fuhrman SA;Patick AK;Zalman LS;Hendrickson TF;Love RA;Prins TJ;Marakovits JT;Zhou R;Tikhe J;Ford CE;Meador JW;Ferre RA;Brown EL;Binford SL;Brothers MA;DeLisle DM;Worland ST View More
10507325 The structures of picornaviral proteinases. Virus Res 1999 Seipelt J;Guarne A;Bergmann E;James M;Sommergruber W;Fita I;Skern T View More
10508022 In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease. Antimicrob Agents Chemother 1999 Patick AK;Binford SL;Brothers MA;Jackson RL;Ford CE;Diem MD;Maldonado F;Dragovich PS;Zhou R;Prins TJ;Fuhrman SA;Meador JW;Zalman LS;Matthews DA;Worland ST View More
10636240 Structure-based design of ketone-containing, tripeptidyl human rhinovirus 3C protease inhibitors. Bioorg Med Chem Lett 2000 Dragovich PS;Zhou R;Webber SE;Prins TJ;Kwok AK;Okano K;Fuhrman SA;Zalman LS;Maldonado FC;Brown EL;Meador JW 3rd;Patick AK;Ford CE;Brothers MA;Binford SL;Matthews DA;Ferre RA;Worland ST View More
10770757 Inhibition of human rhinovirus-induced cytokine production by AG7088, a human rhinovirus 3C protease inhibitor. Antimicrob Agents Chemother 2000 Zalman LS;Brothers MA;Dragovich PS;Zhou R;Prins TJ;Worland ST;Patick AK View More
10794684 Substituted benzamide inhibitors of human rhinovirus 3C protease: structure-based design, synthesis, and biological evaluation. J Med Chem 2000 Reich SH;Johnson T;Wallace MB;Kephart SE;Fuhrman SA;Worland ST;Matthews DA;Hendrickson TF;Chan F;Meador J 3rd;Ferre RA;Brown EL;DeLisle DM;Patick AK;Binford SL;Ford CE View More
10950388 Antiviral therapy for enteroviruses and rhinoviruses. Antivir Chem Chemother 2000 Rotbart HA View More
10999479 S-nitrosothiols as novel, reversible inhibitors of human rhinovirus 3C protease. Bioorg Med Chem Lett 2000 Xian M;Wang QM;Chen X;Wang K;Wang PG View More
11118371 Complete nucleotide sequence of the chiba virus genome and functional expression of the 3C-like protease in Escherichia coli. Virology 2000 Someya Y;Takeda N;Miyamura T View More
11162821 Activation of human rhinovirus-14 3C protease. Virology 2001 Wang QM;Johnson RB View More
11166856 The treatment of rhinovirus infections: progress and potential. Antiviral Res 2001 Turner RB View More
11274152 Disruption of the interaction of mammalian protein synthesis eukaryotic initiation factor 4B with the poly(A)-binding protein by caspase- and viral protease-mediated cleavages. J Biol Chem 2001 Bushell M;Wood W;Carpenter G;Pain VM;Morley SJ;Clemens MJ View More
11302940 Liquid chromatography-mass spectrometry and liquid chromatography-NMR characterization of in vitro metabolites of a potent and irreversible peptidomimetic inhibitor of rhinovirus 3C protease. Drug Metab Dispos 2001 Zhang KE;Hee B;Lee CA;Liang B;Potts BC View More
11378491 Rapid multiserotype detection of human rhinoviruses on optically coated silicon surfaces. J Clin Virol 2001 Ostroff R;Ettinger A;La H;Rihanek M;Zalman L;Meador J 3rd;Patick AK;Worland S;Polisky B View More
11414203 MBP fusion protein with a viral protease cleavage site: one-step cleavage/purification of insoluble proteins. Biotechniques 2001 Alexandrov A;Dutta K;Pascal SM View More
11548209 Protease inhibitors as potential antiviral agents for the treatment of picornaviral infections. Prog Drug Res 2001 Wang QM View More
11591501 Design and synthesis of irreversible depsipeptidyl human rhinovirus 3C protease inhibitors. Bioorg Med Chem Lett 2001 Webber SE;Marakovits JT;Dragovich PS;Prins TJ;Zhou R;Fuhrman SA;Patick AK;Matthews DA;Lee CA;Srinivasan B;Moran T;Ford CE;Brothers MA;Harr JE;Meador JW 3rd;Ferre RA;Worland ST View More
11720861 Discovery, total synthesis, HRV 3C-protease inhibitory activity, and structure-activity relationships of 2-methoxystypandrone and its analogues. Bioorg Med Chem Lett 2001 Singh SB;Graham PL;Reamer RA;Cordingley MG View More
11858991 Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. Part 7: structure-activity studies of bicyclic 2-pyridone-containing peptidomimetics. Bioorg Med Chem Lett 2002 Dragovich PS;Prins TJ;Zhou R;Johnson TO;Brown EL;Maldonado FC;Fuhrman SA;Zalman LS;Patick AK;Matthews DA;Hou X;Meador JW;Ferre RA;Worland ST View More
11900346 Peptidyl diazomethyl ketones inhibit the human rhinovirus 3C protease: effect on virus yield by partial block of P3 polyprotein processing. Antivir Chem Chemother 2001 Murray MA;Janc JW;Venkatraman S;Babe LM View More
11911365 Determinants of the recognition of enteroviral cloverleaf RNA by coxsackievirus B3 proteinase 3C. RNA 2002 Zell R;Sidigi K;Bucci E;Stelzner A;Gorlach M View More
11931615 Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 6. Structure-activity studies of orally bioavailable, 2-pyridone-containing peptidomimetics. J Med Chem 2002 Dragovich PS;Prins TJ;Zhou R;Brown EL;Maldonado FC;Fuhrman SA;Zalman LS;Tuntland T;Lee CA;Patick AK;Matthews DA;Hendrickson TF;Kosa MB;Liu B;Batugo MR;Gleeson JP;Sakata SK;Chen L;Guzman MC;Meador JW 3rd;Ferre RA;Worland ST View More
11985469 Structure-based design of a parallel synthetic array directed toward the discovery of irreversible inhibitors of human rhinovirus 3C protease. J Med Chem 2002 Johnson TO;Hua Y;Luu HT;Brown EL;Chan F;Chu SS;Dragovich PS;Eastman BW;Ferre RA;Fuhrman SA;Hendrickson TF;Maldonado FC;Matthews DA;Meador JW 3rd;Patick AK;Reich SH;Skalitzky DJ;Worland ST;Yang M;Zalman LS View More
12525179 The unusual catalytic triad of poliovirus protease 3C. Biochemistry 2003 Sarkany Z;Polgar L View More
12766405 Backbone 1H, 15N and 13C assignments for the human rhinovirus 3C protease (serotype 14). J Biomol NMR 2003 Bjorndahl TC;Monzavi H;Wishart DS View More
12921996 Encephalomyocarditis virus (EMCV) proteins 2A and 3BCD localize to nuclei and inhibit cellular mRNA transcription but not rRNA transcription. Virus Res 2003 Aminev AG;Amineva SP;Palmenberg AC View More
14505664 Synthesis and evaluation of tripeptidyl alpha-ketoamides as human rhinovirus 3C protease inhibitors. Bioorg Med Chem Lett 2003 Chen SH;Lamar J;Victor F;Snyder N;Johnson R;Heinz BA;Wakulchik M;Wang QM View More
14521419 Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 8. Pharmacological optimization of orally bioavailable 2-pyridone-containing peptidomimetics. J Med Chem 2003 Dragovich PS;Prins TJ;Zhou R;Johnson TO;Hua Y;Luu HT;Sakata SK;Brown EL;Maldonado FC;Tuntland T;Lee CA;Fuhrman SA;Zalman LS;Patick AK;Matthews DA;Wu EY;Guo M;Borer BC;Nayyar NK;Moran T;Chen L;Rejto PA;Rose PW;Guzman MC;Dovalsantos EZ;Lee S;McGee K;Mohajeri M;Liese A;Tao J;Kosa MB;Liu B;Batugo MR;Gleeson JP;Wu ZP;Liu J;Meador JW 3rd;Ferre RA View More
14605258 Rhinovirus 16 3C protease induces interleukin-8 and granulocyte-macrophage colony-stimulating factor expression in human bronchial epithelial cells. Pediatr Res 2004 Funkhouser AW;Kang JA;Tan A;Li J;Zhou L;Abe MK;Solway J;Hershenson MB View More
15168795 An optical thin film assay incorporating rhinovirus protease inhibitors as detector reagents. Antiviral Res 2004 Ettinger A;Ostroff R;Rhihanek M;Dragovich PS;Zalman LS;Patick AK;Prins TJ;Fuhrman SA;Brown EL;Worland ST;Polisky B View More
15448360 Rhinovirus 3C protease precursors 3CD and 3CD\' localize to the nuclei of infected cells. J Gen Virol 2004 Amineva SP;Aminev AG;Palmenberg AC;Gern JE View More
15673742 Conservation of amino acids in human rhinovirus 3C protease correlates with broad-spectrum antiviral activity of rupintrivir, a novel human rhinovirus 3C protease inhibitor. Antimicrob Agents Chemother 2005 Binford SL;Maldonado F;Brothers MA;Weady PT;Zalman LS;Meador JW 3rd;Matthews DA;Patick AK View More
15814817 A novel cGUUAg tetraloop structure with a conserved yYNMGg-type backbone conformation from cloverleaf 1 of bovine enterovirus 1 RNA. Nucleic Acids Res 2005 Ihle Y;Ohlenschlager O;Hafner S;Duchardt E;Zacharias M;Seitz S;Zell R;Ramachandran R;Gorlach M View More
15917520 In vitro antiviral activity and single-dose pharmacokinetics in humans of a novel, orally bioavailable inhibitor of human rhinovirus 3C protease. Antimicrob Agents Chemother 2005 Patick AK;Brothers MA;Maldonado F;Binford S;Maldonado O;Fuhrman S;Petersen A;Smith GJ 3rd;Zalman LS;Burns-Naas LA;Tran JQ View More
16279553 [Rhinovirus diseases: pathogenesis, diagnostics and treatment]. Zh Mikrobiol Epidemiol Immunobiol 2005 Faizuloev EB;Nikonova AA;Zverev VV View More
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1654789 Development of synthetic peptide substrates for the poliovirus 3C proteinase. Arch Biochem Biophys 1991 Weidner JR;Dunn BM View More
1658106 Rhinovirus 3C protease catalyzes efficient cleavage of a fluorescein-labeled peptide affording a rapid and robust assay. J Biochem Biophys Methods 1991 Hopkins JL;Betageri R;Cohen KA;Emmanuel MJ;Joseph CR;Bax PM;Pallai PV;Skoog MT View More
17267501 MDA-5 is cleaved in poliovirus-infected cells. J Virol 2007 Barral PM;Morrison JM;Drahos J;Gupta P;Sarkar D;Fisher PB;Racaniello VR View More
17305557 Human rhinovirus 3C protease as a potential target for the development of antiviral agents. Curr Protein Pept Sci 2007 Wanga QM;Chen SH View More
17374764 PDTC inhibits picornavirus polyprotein processing and RNA replication by transporting zinc ions into cells. J Gen Virol 2007 Lanke K;Krenn BM;Melchers WJG;Seipelt J;van Kuppeveld FJM View More
17485072 Development of potent inhibitors of the coxsackievirus 3C protease. Biochem Biophys Res Commun 2007 Lee ES;Lee WG;Yun SH;Rho SH;Im I;Yang ST;Sellamuthu S;Lee YJ;Kwon SJ;Park OK;Jeon ES;Park WJ;Kim YC View More
17908951 In vitro resistance study of rupintrivir, a novel inhibitor of human rhinovirus 3C protease. Antimicrob Agents Chemother 2007 Binford SL;Weady PT;Maldonado F;Brothers MA;Matthews DA;Patick AK View More
17944485 NMR solution structures of the apo and peptide-inhibited human rhinovirus 3C protease (Serotype 14): structural and dynamic comparison. Biochemistry 2007 Bjorndahl TC;Andrew LC;Semenchenko V;Wishart DS View More
18248816 New anti-viral drugs for the treatment of the common cold. Bioorg Med Chem 2008 Maugeri C;Alisi MA;Apicella C;Cellai L;Dragone P;Fioravanzo E;Florio S;Furlotti G;Mangano G;Ombrato R;Luisi R;Pompei R;Rincicotti V;Russo V;Vitiello M;Cazzolla N View More
18572216 Cleavage of eukaryotic initiation factor eIF5B by enterovirus 3C proteases. Virology 2008 de Breyne S;Bonderoff JM;Chumakov KM;Lloyd RE;Hellen CU View More
18583140 Design, synthesis, and evaluation of 3C protease inhibitors as anti-enterovirus 71 agents. Bioorg Med Chem 2008 Kuo CJ;Shie JJ;Fang JM;Yen GR;Hsu JT;Liu HG;Tseng SN;Chang SC;Lee CY;Shih SR;Liang PH View More
19048198 Viral protease inhibitors. Handb Exp Pharmacol 2009 Anderson J;Schiffer C;Lee SK;Swanstrom R View More
19268541 A picornaviral loop-to-loop replication complex. J Struct Biol 2009 Claridge JK;Headey SJ;Chow JY;Schwalbe M;Edwards PJ;Jeffries CM;Venugopal H;Trewhella J;Pascal SM View More
19333433 Over-expression, rapid preparation and some properties of c-terminal BARc region in PICK1. Int J Mol Sci 2009 Xiao H;Shi Y;Yuan J;Huang Y;Wang J View More
19403669 Rhinovirus 3C protease can localize in the nucleus and alter active and passive nucleocytoplasmic transport. J Virol 2009 Ghildyal R;Jordan B;Li D;Dagher H;Bardin PG;Gern JE;Jans DA View More
19457455 Robust production of a peptide library using methodological synchronization. Protein Expr Purif 2009 Huber KL;Olson KD;Hardy JA View More
19464175 Structure-activity relationships of heteroaromatic esters as human rhinovirus 3C protease inhibitors. Bioorg Med Chem Lett 2009 Im I;Lee ES;Choi SJ;Lee JY;Kim YC View More
19628239 RIG-I is cleaved during picornavirus infection. Virology 2009 Barral PM;Sarkar D;Fisher PB;Racaniello VR View More
20021285 Picornaviral 3C protease inhibitors and the dual 3C protease/coronaviral 3C-like protease inhibitors. Expert Opin Ther Pat 2010 Wang HM;Liang PH View More
20066739 Rupintrivir is a promising candidate for treating severe cases of Enterovirus-71 infection. World J Gastroenterol 2010 Zhang XN;Song ZG;Jiang T;Shi BS;Hu YW;Yuan ZH View More
21183345 Non-covalent inhibitors of rhinovirus 3C protease. Bioorg Med Chem Lett 2011 Baxter A;Chambers M;Edfeldt F;Edman K;Freeman A;Johansson C;King S;Morley A;Petersen J;Rawlins P;Spadola L;Thong B;Van de Poel H;Williams N View More
21543871 Crystallization and preliminary diffraction analysis of the CAL PDZ domain in complex with a selective peptide inhibitor. Acta Crystallogr Sect F Struct Biol Cryst Commun 2011 Amacher JF;Cushing PR;Weiner JA;Madden DR View More
21605680 Production and single-step purification of EGFP and a biotinylated version of the Human Rhinovirus 14 3C protease. Protein Expr Purif 2011 Youell J;Fordham D;Firman K View More
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21795339 Enterovirus 71 and coxsackievirus A16 3C proteases: binding to rupintrivir and their substrates and anti-hand, foot, and mouth disease virus drug design. J Virol 2011 Lu G;Qi J;Chen Z;Xu X;Gao F;Lin D;Qian W;Liu H;Jiang H;Yan J;Gao GF View More
21813612 Crystal structures of enterovirus 71 3C protease complexed with rupintrivir reveal the roles of catalytically important residues. J Virol 2011 Wang J;Fan T;Yao X;Wu Z;Guo L;Lei X;Wang J;Wang M;Jin Q;Cui S View More
21835784 Structural basis for antiviral inhibition of the main protease, 3C, from human enterovirus 93. J Virol 2011 Costenaro L;Kaczmarska Z;Arnan C;Janowski R;Coutard B;Sola M;Gorbalenya AE;Norder H;Canard B;Coll M View More
21936817 Recent development of 3C and 3CL protease inhibitors for anti-coronavirus and anti-picornavirus drug discovery. Biochem Soc Trans 2011 Ramajayam R;Tan KP;Liang PH View More
22763202 A simple solid phase, peptide-based fluorescent assay for the efficient and universal screening of HRV 3C protease inhibitors. Bioorg Med Chem Lett 2012 Schunemann K;Connelly S;Kowalczyk R;Sperry J;Wilson IA;Fraser JD;Brimble MA View More
23131833 Picornavirus modification of a host mRNA decay protein. mBio 2012 Rozovics JM;Chase AJ;Cathcart AL;Chou W;Gershon PD;Palusa S;Wilusz J;Semler BL View More
23255796 Viral proteinase requirements for the nucleocytoplasmic relocalization of cellular splicing factor SRp20 during picornavirus infections. J Virol 2013 Fitzgerald KD;Chase AJ;Cathcart AL;Tran GP;Semler BL View More
23300834 Express your LOV: an engineered flavoprotein as a reporter for protein expression and purification. PLoS One 2012 Gawthorne JA;Reddick LE;Akpunarlieva SN;Beckham KS;Christie JM;Alto NM;Gabrielsen M;Roe AJ View More
23388726 3C protease of enterovirus 68: structure-based design of Michael acceptor inhibitors and their broad-spectrum antiviral effects against picornaviruses. J Virol 2013 Tan J;George S;Kusov Y;Perbandt M;Anemuller S;Mesters JR;Norder H;Coutard B;Lacroix C;Leyssen P;Neyts J;Hilgenfeld R View More
23395976 Differential temperature dependence of tobacco etch virus and rhinovirus 3C proteases. Anal Biochem 2013 Raran-Kurussi S;Tozser J;Cherry S;Tropea JE;Waugh DS View More
23410102 A new method to customize protein expression vectors for fast, efficient and background free parallel cloning. BMC Biotechnol 2013 Scholz J;Besir H;Strasser C;Suppmann S View More
23633597 Structures of Enterovirus 71 3C proteinase (strain E2004104-TW-CDC) and its complex with rupintrivir. Acta Crystallogr D Biol Crystallogr 2013 Wu C;Cai Q;Chen C;Li N;Peng X;Cai Y;Yin K;Chen X;Wang X;Zhang R;Liu L;Chen S;Li J;Lin T View More
23903828 Cellular mRNA decay protein AUF1 negatively regulates enterovirus and human rhinovirus infections. J Virol 2013 Cathcart AL;Rozovics JM;Semler BL View More
23951130 Rhinovirus 3C protease facilitates specific nucleoporin cleavage and mislocalisation of nuclear proteins in infected host cells. PLoS One 2013 Walker EJ;Younessi P;Fulcher AJ;McCuaig R;Thomas BJ;Bardin PG;Jans DA;Ghildyal R View More
24346589 Synthesis of the 2-methylene analogue of the HRV 3C protease inhibitor thysanone (2-carbathysanone). Org Biomol Chem 2014 Schunemann K;Furkert DP;Choi EC;Connelly S;Fraser JD;Sperry J;Brimble MA View More
24649897 A new fusion protein platform for quantitatively measuring activity of multiple proteases. Microb Cell Fact 2014 Zhou C;Yan Y;Fang J;Cheng B;Fan J View More
24727155 A novel self-cleavage system for production of soluble recombinant protein in Escherichia coli. Protein Expr Purif 2014 Feng Y;Xu Q;Yang T;Sun E;Li J;Shi D;Wu D View More
25259514 Synthesis and evaluation of 9-deoxy analogues of (-)-thysanone, an inhibitor of HRV 3C protease. Eur J Med Chem 2014 Young Jeong J;Sperry J;Taylor JA;Brimble MA View More
25261311 Proteases of human rhinovirus: role in infection. Methods Mol Biol 2015 Jensen LM;Walker EJ;Jans DA;Ghildyal R View More
25261312 A protocol to express and isolate HRV16 3C protease for use in protease assays. Methods Mol Biol 2015 Jensen LM;Walker EJ;Ghildyal R View More
25350699 Novel prodrug-like fusion toxin with protease-sensitive bioorthogonal PEGylation for tumor targeting. Bioconjug Chem 2014 Stefan N;Zimmermann M;Simon M;Zangemeister-Wittke U;Pluckthun A View More
2546760 The expression and purification of human rhinovirus protease 3C. Eur J Biochem 1989 Knott JA;Orr DC;Montgomery DS;Sullivan CA;Weston A View More
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25792507 Peptidomimetic ethyl propenoate covalent inhibitors of the enterovirus 71 3C protease: a P2-P4 study. J Enzyme Inhib Med Chem 2016 Ang MJ;Lau QY;Ng FM;Then SW;Poulsen A;Cheong YK;Ngoh ZX;Tan YW;Peng J;Keller TH;Hill J;Chu JJ;Chia CS View More
27093053 Activity of the Human Rhinovirus 3C Protease Studied in Various Buffers, Additives and Detergents Solutions for Recombinant Protein Production. PLoS One 2016 Ullah R;Shah MA;Tufail S;Ismat F;Imran M;Iqbal M;Mirza O;Rhaman M View More
27105777 A dual protease approach for expression and affinity purification of recombinant proteins. Anal Biochem 2016 Raran-Kurussi S;Waugh DS View More
27265257 Design and structure-activity relationships of novel inhibitors of human rhinovirus 3C protease. Bioorg Med Chem Lett 2016 Kawatkar SP;Gagnon M;Hoesch V;Tiong-Yip C;Johnson K;Ek M;Nilsson E;Lister T;Olsson L;Patel J;Yu Q View More
27645381 Antiviral activities of peptide-based covalent inhibitors of the Enterovirus 71 3C protease. Sci Rep 2016 Tan YW;Ang MJ;Lau QY;Poulsen A;Ng FM;Then SW;Peng J;Hill J;Hong WJ;Chia CS;Chu JJ View More
27681132 Rhinovirus 16 2A Protease Affects Nuclear Localization of 3CD during Infection. J Virol 2016 Walker E;Jensen L;Croft S;Wei K;Fulcher AJ;Jans DA;Ghildyal R View More
28217559 A Novel Enterovirus 71 (EV71) Virulence Determinant: The 69th Residue of 3C Protease Modulates Pathogenicity. Front Cell Infect Microbiol 2017 Li B;Yue Y;Zhang Y;Yuan Z;Li P;Song N;Lin W;Liu Y;Gu L;Meng H View More
28778471 Design, synthesis and evaluation of 2,2-dimethyl-1,3-dioxolane derivatives as human rhinovirus 3C protease inhibitors. Bioorg Med Chem Lett 2017 Zhang Q;Cao R;Liu A;Lei S;Li Y;Yang J;Li S;Xiao J View More
28801725 Optimization of Soluble Expression and Purification of Recombinant Human Rhinovirus Type-14 3C Protease Using Statistically Designed Experiments: Isolation and Characterization of the Enzyme. Mol Biotechnol 2017 Antoniou G;Papakyriacou I;Papaneophytou C View More
29371673 Human Rhinovirus 3C protease cleaves RIPK1, concurrent with caspase 8 activation. Sci Rep 2018 Croft SN;Walker EJ;Ghildyal R View More
29433930 Structure-based design and synthesis of macrocyclic human rhinovirus 3C protease inhibitors. Bioorg Med Chem Lett 2018 Namoto K;Sirockin F;Sellner H;Wiesmann C;Villard F;Moreau RJ;Valeur E;Paulding SC;Schleeger S;Schipp K;Loup J;Andrews L;Swale R;Robinson M;Farady CJ View More
29449668 Rhinovirus 3C protease suppresses apoptosis and triggers caspase-independent cell death. Cell Death Dis 2018 Lotzerich M;Roulin PS;Boucke K;Witte R;Georgiev O;Greber UF View More
29530860 Selection and Characterization of Rupintrivir-Resistant Norwalk Virus Replicon Cells In Vitro. Antimicrob Agents Chemother 2018 Kitano M;Hosmillo M;Emmott E;Lu J;Goodfellow I View More
29866517 Identification of quinone analogues as potential inhibitors of picornavirus 3C protease in vitro. Bioorg Med Chem Lett 2018 Jung E;Lee JY;Kim HJ;Ryu CK;Lee KI;Kim M;Lee CK;Go YY View More
30118570 Building and Breaking Bonds via a Compact S-Propargyl-Cysteine to Chemically Control Enzymes and Modify Proteins. Angew Chem Int Ed Engl 2018 Liu J;Cheng R;Wu H;Li S;Wang PG;DeGrado WF;Rozovsky S;Wang L View More
30352199 Development of a homogeneous time-resolved fluorescence assay for detection of viral double-stranded RNA. Anal Biochem 2019 Fujita M;Adachi K;Nagasawa M View More
30461192 Toward development of generic inhibitors against the 3C proteases of picornaviruses. FEBS J 2019 Banerjee K;Bhat R;Rao VUB;Nain A;Rallapalli KL;Gangopadhyay S;Singh RP;Banerjee M;Jayaram B View More
30646829 Good and bad molecular fingerprints for human rhinovirus 3C protease inhibition: identification, validation, and application in designing of new inhibitors through Monte Carlo-based QSAR study. J Biomol Struct Dyn 2020 Jain S;Amin SA;Adhikari N;Jha T;Gayen S View More
30686346 A simplified method to remove fusion tags from a xylanase of Bacillus sp. HBP8 with HRV 3C protease. Enzyme Microb Technol 2019 Xu H;Wang Q;Zhang Z;Yi L;Ma L;Zhai C View More
30802413 A General Guide for the Optimization of Enzyme Assay Conditions Using the Design of Experiments Approach. SLAS Discov 2019 Onyeogaziri FC;Papaneophytou C View More
30844608 New 4-phenylcoumarin derivatives as potent 3C protease inhibitors: Design, synthesis, anti-HAV effect and molecular modeling. Eur J Med Chem 2019 Kassem AF;Batran RZ;Abbas EMH;Elseginy SA;Shaheen MNF;Elmahdy EM View More
30868206 Soluble expression of IGF1 fused to DsbA in SHuffle T7 strain: optimization of expression and purification by Box-Behnken design. Appl Microbiol Biotechnol 2019 Emamipour N;Vossoughi M;Mahboudi F;Golkar M;Fard-Esfahani P View More
31117169 Design of a Human Rhinovirus-14 3C Protease-Inducible Caspase-3. Molecules 2019 Wagner HJ;Weber W View More
31612259 Using the IPTG-Inducible Pgrac212 Promoter for Overexpression of Human Rhinovirus 3C Protease Fusions in the Cytoplasm of Bacillus subtilis Cells. Curr Microbiol 2019 Le VD;Phan TTP;Nguyen TM;Brunsveld L;Schumann W;Nguyen HD View More
31613083 Quantitative Analysis of the Substrate Specificity of Human Rhinovirus 3C Protease and Exploration of Its Substrate Recognition Mechanisms. ACS Chem Biol 2020 Fan X;Li X;Zhou Y;Mei M;Liu P;Zhao J;Peng W;Jiang ZB;Yang S;Iverson BL;Zhang G;Yi L View More
32103448 Structure of the HRV-C 3C-Rupintrivir Complex Provides New Insights for Inhibitor Design. Virol Sin 2020 Yuan S;Fan K;Chen Z;Sun Y;Hou H;Zhu L View More
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33093214 Enteroviral 3C protease activates the human NLRP1 inflammasome in airway epithelia. Science 2020 Robinson KS;Teo DET;Tan KS;Toh GA;Ong HH;Lim CK;Lay K;Au BV;Lew TS;Chu JJH;Chow VTK;Wang Y;Zhong FL;Reversade B View More
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