| 10353638
|
Solid-phase synthesis of irreversible human rhinovirus 3C protease inhibitors. Part 1: Optimization of tripeptides incorporating N-terminal amides. |
Bioorg Med Chem |
1999 |
Dragovich PS;Zhou R;Skalitzky DJ;Fuhrman SA;Patick AK;Ford CE;Meador JW 3rd;Worland ST |
View
More |
| 10396129
|
Protease inhibitors as potential antiviral agents for the treatment of picornaviral infections. |
Prog Drug Res |
1999 |
Wang QM |
View
More |
| 10465543
|
Structure-based design of irreversible, tripeptidyl human rhinovirus 3C protease inhibitors containing N-methyl amino acids. |
Bioorg Med Chem Lett |
1999 |
Dragovich PS;Webber SE;Prins TJ;Zhou R;Marakovits JT;Tikhe JG;Fuhrman SA;Patick AK;Matthews DA;Ford CE;Brown EL;Binford SL;Meador JW 3rd;Ferre RA;Worland ST |
View
More |
| 10921773
|
A novel method of aligning molecules by local surface shape similarity. |
J Comput Aided Mol Des |
2000 |
Cosgrove DA;Bayada DM;Johnson AP |
View
More |
| 11249711
|
AG-7088 Pfizer. |
Curr Opin Investig Drugs |
2000 |
Witherell G |
View
More |
| 11302940
|
Liquid chromatography-mass spectrometry and liquid chromatography-NMR characterization of in vitro metabolites of a potent and irreversible peptidomimetic inhibitor of rhinovirus 3C protease. |
Drug Metab Dispos |
2001 |
Zhang KE;Hee B;Lee CA;Liang B;Potts BC |
View
More |
| 11548209
|
Protease inhibitors as potential antiviral agents for the treatment of picornaviral infections. |
Prog Drug Res |
2001 |
Wang QM |
View
More |
| 11591501
|
Design and synthesis of irreversible depsipeptidyl human rhinovirus 3C protease inhibitors. |
Bioorg Med Chem Lett |
2001 |
Webber SE;Marakovits JT;Dragovich PS;Prins TJ;Zhou R;Fuhrman SA;Patick AK;Matthews DA;Lee CA;Srinivasan B;Moran T;Ford CE;Brothers MA;Harr JE;Meador JW 3rd;Ferre RA;Worland ST |
View
More |
| 11681658
|
Characterization of nasal spray pumps and deposition pattern in a replica of the human nasal airway. |
J Aerosol Med |
2001 |
Cheng YS;Holmes TD;Gao J;Guilmette RA;Li S;Surakitbanharn Y;Rowlings C |
View
More |
| 11720861
|
Discovery, total synthesis, HRV 3C-protease inhibitory activity, and structure-activity relationships of 2-methoxystypandrone and its analogues. |
Bioorg Med Chem Lett |
2001 |
Singh SB;Graham PL;Reamer RA;Cordingley MG |
View
More |
| 11931615
|
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 6. Structure-activity studies of orally bioavailable, 2-pyridone-containing peptidomimetics. |
J Med Chem |
2002 |
Dragovich PS;Prins TJ;Zhou R;Brown EL;Maldonado FC;Fuhrman SA;Zalman LS;Tuntland T;Lee CA;Patick AK;Matthews DA;Hendrickson TF;Kosa MB;Liu B;Batugo MR;Gleeson JP;Sakata SK;Chen L;Guzman MC;Meador JW 3rd;Ferre RA;Worland ST |
View
More |
| 1331062
|
Cleavage specificity on synthetic peptide substrates of human rhinovirus 2 proteinase 2A. |
J Biol Chem |
1992 |
Sommergruber W;Ahorn H;Zophel A;Maurer-Fogy I;Fessl F;Schnorrenberg G;Liebig HD;Blaas D;Kuechler E;Skern T |
View
More |
| 14505664
|
Synthesis and evaluation of tripeptidyl alpha-ketoamides as human rhinovirus 3C protease inhibitors. |
Bioorg Med Chem Lett |
2003 |
Chen SH;Lamar J;Victor F;Snyder N;Johnson R;Heinz BA;Wakulchik M;Wang QM |
View
More |
| 14521419
|
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 8. Pharmacological optimization of orally bioavailable 2-pyridone-containing peptidomimetics. |
J Med Chem |
2003 |
Dragovich PS;Prins TJ;Zhou R;Johnson TO;Hua Y;Luu HT;Sakata SK;Brown EL;Maldonado FC;Tuntland T;Lee CA;Fuhrman SA;Zalman LS;Patick AK;Matthews DA;Wu EY;Guo M;Borer BC;Nayyar NK;Moran T;Chen L;Rejto PA;Rose PW;Guzman MC;Dovalsantos EZ;Lee S;McGee K;Mohajeri M;Liese A;Tao J;Kosa MB;Liu B;Batugo MR;Gleeson JP;Wu ZP;Liu J;Meador JW 3rd;Ferre RA |
View
More |
| 15168795
|
An optical thin film assay incorporating rhinovirus protease inhibitors as detector reagents. |
Antiviral Res |
2004 |
Ettinger A;Ostroff R;Rhihanek M;Dragovich PS;Zalman LS;Patick AK;Prins TJ;Fuhrman SA;Brown EL;Worland ST;Polisky B |
View
More |
| 15170592
|
Selective human enterovirus and rhinovirus inhibitors: An overview of capsid-binding and protease-inhibiting molecules. |
Med Res Rev |
2004 |
Shih SR;Chen SJ;Hakimelahi GH;Liu HJ;Tseng CT;Shia KS |
View
More |
| 15578974
|
Recent advances in rhinovirus therapeutics. |
Curr Drug Targets Infect Disord |
2004 |
Charles CH;Yelmene M;Luo GX |
View
More |
| 15592828
|
Inhibitors of virus replication: recent developments and prospects. |
Appl Microbiol Biotechnol |
2005 |
Magden J;Kaariainen L;Ahola T |
View
More |
| 15673742
|
Conservation of amino acids in human rhinovirus 3C protease correlates with broad-spectrum antiviral activity of rupintrivir, a novel human rhinovirus 3C protease inhibitor. |
Antimicrob Agents Chemother |
2005 |
Binford SL;Maldonado F;Brothers MA;Weady PT;Zalman LS;Meador JW 3rd;Matthews DA;Patick AK |
View
More |
| 15921461
|
Human rhinovirus 3C protease: generation of pharmacophore models for peptidic and nonpeptidic inhibitors and their application in virtual screening. |
J Chem Inf Model |
2005 |
Steindl T;Laggner C;Langer T |
View
More |
| 16279553
|
[Rhinovirus diseases: pathogenesis, diagnostics and treatment]. |
Zh Mikrobiol Epidemiol Immunobiol |
2005 |
Faizuloev EB;Nikonova AA;Zverev VV |
View
More |
| 16611122
|
Current status of anti-picornavirus therapies. |
Curr Pharm Des |
2006 |
Barnard DL |
View
More |
| 16675037
|
Rhinovirus chemotherapy. |
Antiviral Res |
2006 |
Patick AK |
View
More |
| 18190777
|
A mammalian cell-based reverse two-hybrid system for functional analysis of 3C viral protease of human enterovirus 71. |
Anal Biochem |
2008 |
Lee JC;Shih SR;Chang TY;Tseng HY;Shih YF;Yen KJ;Chen WC;Shie JJ;Fang JM;Liang PH;Chao YS;Hsu JT |
View
More |
| 18381747
|
Selective inhibitors of picornavirus replication. |
Med Res Rev |
2008 |
De Palma AM;Vliegen I;De Clercq E;Neyts J |
View
More |
| 19048198
|
Viral protease inhibitors. |
Handb Exp Pharmacol |
2009 |
Anderson J;Schiffer C;Lee SK;Swanstrom R |
View
More |
| 20021285
|
Picornaviral 3C protease inhibitors and the dual 3C protease/coronaviral 3C-like protease inhibitors. |
Expert Opin Ther Pat |
2010 |
Wang HM;Liang PH |
View
More |
| 20066739
|
Rupintrivir is a promising candidate for treating severe cases of Enterovirus-71 infection. |
World J Gastroenterol |
2010 |
Zhang XN;Song ZG;Jiang T;Shi BS;Hu YW;Yuan ZH |
View
More |
| 21936817
|
Recent development of 3C and 3CL protease inhibitors for anti-coronavirus and anti-picornavirus drug discovery. |
Biochem Soc Trans |
2011 |
Ramajayam R;Tan KP;Liang PH |
View
More |
| 22865380
|
Blocking human enterovirus 71 replication by targeting viral 2A protease. |
J Antimicrob Chemother |
2012 |
Falah N;Montserret R;Lelogeais V;Schuffenecker I;Lina B;Cortay JC;Violot S |
View
More |
| 23388726
|
3C protease of enterovirus 68: structure-based design of Michael acceptor inhibitors and their broad-spectrum antiviral effects against picornaviruses. |
J Virol |
2013 |
Tan J;George S;Kusov Y;Perbandt M;Anemuller S;Mesters JR;Norder H;Coutard B;Lacroix C;Leyssen P;Neyts J;Hilgenfeld R |
View
More |
| 23549610
|
The newly emerged SARS-like coronavirus HCoV-EMC also has an "Achilles\' heel": current effective inhibitor targeting a 3C-like protease. |
Protein Cell |
2013 |
Ren Z;Yan L;Zhang N;Guo Y;Yang C;Lou Z;Rao Z |
View
More |
| 24125888
|
Design, synthesis, and bioevaluation of viral 3C and 3C-like protease inhibitors. |
Bioorg Med Chem Lett |
2013 |
Prior AM;Kim Y;Weerasekara S;Moroze M;Alliston KR;Uy RA;Groutas WC;Chang KO;Hua DH |
View
More |
| 24346589
|
Synthesis of the 2-methylene analogue of the HRV 3C protease inhibitor thysanone (2-carbathysanone). |
Org Biomol Chem |
2014 |
Schunemann K;Furkert DP;Choi EC;Connelly S;Fraser JD;Sperry J;Brimble MA |
View
More |
| 25259514
|
Synthesis and evaluation of 9-deoxy analogues of (-)-thysanone, an inhibitor of HRV 3C protease. |
Eur J Med Chem |
2014 |
Young Jeong J;Sperry J;Taylor JA;Brimble MA |
View
More |
| 2555433
|
Hydrolysis of a series of synthetic peptide substrates by the human rhinovirus 14 3C proteinase, cloned and expressed in Escherichia coli. |
J Gen Virol |
1989 |
Orr DC;Long AC;Kay J;Dunn BM;Cameron JM |
View
More |
| 25792507
|
Peptidomimetic ethyl propenoate covalent inhibitors of the enterovirus 71 3C protease: a P2-P4 study. |
J Enzyme Inhib Med Chem |
2016 |
Ang MJ;Lau QY;Ng FM;Then SW;Poulsen A;Cheong YK;Ngoh ZX;Tan YW;Peng J;Keller TH;Hill J;Chu JJ;Chia CS |
View
More |
| 26055377
|
The enterovirus 3C protease inhibitor SG85 efficiently blocks rhinovirus replication and is not cross-resistant with rupintrivir. |
Antimicrob Agents Chemother |
2015 |
Lacroix C;George S;Leyssen P;Hilgenfeld R;Neyts J |
View
More |
| 26149998
|
In Vitro Efficacy of Antiviral Compounds against Enterovirus D68. |
Antimicrob Agents Chemother |
2015 |
Rhoden E;Zhang M;Nix WA;Oberste MS |
View
More |
| 27645381
|
Antiviral activities of peptide-based covalent inhibitors of the Enterovirus 71 3C protease. |
Sci Rep |
2016 |
Tan YW;Ang MJ;Lau QY;Poulsen A;Ng FM;Then SW;Peng J;Hill J;Hong WJ;Chia CS;Chu JJ |
View
More |
| 27733646
|
Clinical Isolates of Human Coronavirus 229E Bypass the Endosome for Cell Entry. |
J Virol |
2017 |
Shirato K;Kanou K;Kawase M;Matsuyama S |
View
More |
| 2781219
|
Secretory leukocyte protease inhibitor in normal, allergic and virus induced nasal secretions. |
Rhinology |
1989 |
Fryksmark U;Jannert M;Ohlsson K;Tegner H;Wihl JA |
View
More |
| 28411509
|
Direct-acting antivirals and host-targeting strategies to combat enterovirus infections. |
Curr Opin Virol |
2017 |
Bauer L;Lyoo H;van der Schaar HM;Strating JR;van Kuppeveld FJ |
View
More |
| 28778471
|
Design, synthesis and evaluation of 2,2-dimethyl-1,3-dioxolane derivatives as human rhinovirus 3C protease inhibitors. |
Bioorg Med Chem Lett |
2017 |
Zhang Q;Cao R;Liu A;Lei S;Li Y;Yang J;Li S;Xiao J |
View
More |
| 29866517
|
Identification of quinone analogues as potential inhibitors of picornavirus 3C protease in vitro. |
Bioorg Med Chem Lett |
2018 |
Jung E;Lee JY;Kim HJ;Ryu CK;Lee KI;Kim M;Lee CK;Go YY |
View
More |
| 3023407
|
Viral therapy: prospects for protease inhibitors. |
J Cell Biochem |
1986 |
Korant BD;Towatari T;Ivanoff L;Petteway S Jr;Brzin J;Lenarcic B;Turk V |
View
More |
| 30352199
|
Development of a homogeneous time-resolved fluorescence assay for detection of viral double-stranded RNA. |
Anal Biochem |
2019 |
Fujita M;Adachi K;Nagasawa M |
View
More |
| 30461192
|
Toward development of generic inhibitors against the 3C proteases of picornaviruses. |
FEBS J |
2019 |
Banerjee K;Bhat R;Rao VUB;Nain A;Rallapalli KL;Gangopadhyay S;Singh RP;Banerjee M;Jayaram B |
View
More |
| 30646829
|
Good and bad molecular fingerprints for human rhinovirus 3C protease inhibition: identification, validation, and application in designing of new inhibitors through Monte Carlo-based QSAR study. |
J Biomol Struct Dyn |
2020 |
Jain S;Amin SA;Adhikari N;Jha T;Gayen S |
View
More |
| 3067861
|
Viral proteases: an emerging therapeutic target. |
Crit Rev Biotechnol |
1988 |
Korant BD |
View
More |
| 30844608
|
New 4-phenylcoumarin derivatives as potent 3C protease inhibitors: Design, synthesis, anti-HAV effect and molecular modeling. |
Eur J Med Chem |
2019 |
Kassem AF;Batran RZ;Abbas EMH;Elseginy SA;Shaheen MNF;Elmahdy EM |
View
More |
| 32310621
|
Coronavirus Infections in Children Including COVID-19: An Overview of the Epidemiology, Clinical Features, Diagnosis, Treatment and Prevention Options in Children. |
Pediatr Infect Dis J |
2020 |
Zimmermann P;Curtis N |
View
More |
| 32448818
|
Protease Inhibitors: Candidate Drugs to Inhibit Severe Acute Respiratory Syndrome Coronavirus 2 Replication. |
Tohoku J Exp Med |
2020 |
Yamaya M;Nishimura H;Deng X;Kikuchi A;Nagatomi R |
View
More |
| 32948116
|
Identification of potential inhibitors of SARS-CoV-2 main protease and spike receptor from 10 important spices through structure-based virtual screening and molecular dynamic study. |
J Biomol Struct Dyn |
2022 |
Sen D;Debnath P;Debnath B;Bhaumik S;Debnath S |
View
More |
| 33225870
|
In silico screening predicts common cold drug Dextromethorphan along with Prednisolone and Dexamethasone can be effective against novel Coronavirus disease (COVID-19). |
J Biomol Struct Dyn |
2022 |
Sarkar I;Sen A |
View
More |
| 33515606
|
Dual inhibition of SARS-CoV-2 and human rhinovirus with protease inhibitors in clinical development. |
Antiviral Res |
2021 |
Liu C;Boland S;Scholle MD;Bardiot D;Marchand A;Chaltin P;Blatt LM;Beigelman L;Symons JA;Raboisson P;Gurard-Levin ZA;Vandyck K;Deval J |
View
More |
| 33641023
|
Structure-activity relationship (SAR) and molecular dynamics study of withaferin-A fragment derivatives as potential therapeutic lead against main protease (M(pro)) of SARS-CoV-2. |
J Mol Model |
2021 |
Ghosh A;Chakraborty M;Chandra A;Alam MP |
View
More |
| 34821198
|
In silico screening and covalent binding of phytochemicals of Ocimum sanctum against SARS-CoV-2 (COVID 19) main protease. |
J Biomol Struct Dyn |
2023 |
Mohapatra PK;Chopdar KS;Dash GC;Mohanty AK;Raval MK |
View
More |
| 34960671
|
RIPK1 Is Cleaved by 3C Protease of Rhinovirus A and B Strains and Minor and Major Groups. |
Viruses |
2021 |
Croft SN;Walker EJ;Ghildyal R |
View
More |
| 35278580
|
Label-free duplex SAMDI-MS screen reveals novel SARS-CoV-2 3CLpro inhibitors. |
Antiviral Res |
2022 |
Scholle MD;O'Kane PT;Dib S;Gurard-Levin ZA |
View
More |
| 6249164
|
Proteolytic events in replication of animal viruses. |
Ann N Y Acad Sci |
1980 |
Korant BD;Chow NL;Lively MO;Powers JC |
View
More |
| 7765405
|
A high capacity microbial screen for inhibitors of human rhinovirus protease 3C. |
Biotechnology (N Y) |
1994 |
McCall JO;Kadam S;Katz L |
View
More |
| 7794931
|
Peptide aldehyde inhibitors of hepatitis A virus 3C proteinase. |
Biochemistry |
1995 |
Malcolm BA;Lowe C;Shechosky S;McKay RT;Yang CC;Shah VJ;Simon RJ;Vederas JC;Santi DV |
View
More |
| 7919786
|
Protein structure--based drug design. |
Annu Rev Biophys Biomol Struct |
1994 |
Whittle PJ;Blundell TL |
View
More |
| 8320292
|
Structural and mechanistic aspects of 3C proteases from the Picornavirus family. |
J Chem Inf Comput Sci |
1993 |
Arad D;Kreisberg R;Shokhen M |
View
More |
| 8392608
|
Inhibition of proteolytic activity of poliovirus and rhinovirus 2A proteinases by elastase-specific inhibitors. |
J Virol |
1993 |
Molla A;Hellen CU;Wimmer E |
View
More |
| 8698636
|
Novel triterpene sulfates from Fusarium compactum using a rhinovirus 3C protease inhibitor screen. |
J Antibiot (Tokyo) |
1996 |
Brill GM;Kati WM;Montgomery D;Karwowski JP;Humphrey PE;Jackson M;Clement JJ;Kadam S;Chen RH;McAlpine JB |
View
More |
| 8787922
|
Simple in vitro translation assay to analyze inhibitors of rhinovirus proteases. |
Antimicrob Agents Chemother |
1996 |
Heinz BA;Tang J;Labus JM;Chadwell FW;Kaldor SW;Hammond M |
View
More |
| 8978838
|
Design, synthesis, and evaluation of nonpeptidic inhibitors of human rhinovirus 3C protease. |
J Med Chem |
1996 |
Webber SE;Tikhe J;Worland ST;Fuhrman SA;Hendrickson TF;Matthews DA;Love RA;Patick AK;Meador JW;Ferre RA;Brown EL;DeLisle DM;Ford CE;Binford SL |
View
More |
| 9559808
|
Dual inhibition of human rhinovirus 2A and 3C proteases by homophthalimides. |
Antimicrob Agents Chemother |
1998 |
Wang QM;Johnson RB;Jungheim LN;Cohen JD;Villarreal EC |
View
More |
| 9681985
|
Development of in vitro peptide substrates for human rhinovirus-14 2A protease. |
Arch Biochem Biophys |
1998 |
Wang QM;Johnson RB;Sommergruber W;Shepherd TA |
View
More |
| 9767059
|
Protease inhibitors as antiviral agents. |
Clin Microbiol Rev |
1998 |
Patick AK;Potts KE |
View
More |
| 9989947
|
Inhibition of 3C protease from human rhinovirus strain 1B by peptidyl bromomethylketonehydrazides. |
Arch Biochem Biophys |
1999 |
Kati WM;Sham HL;McCall JO;Montgomery DA;Wang GT;Rosenbrook W;Miesbauer L;Buko A;Norbeck DW |
View
More |
