| Title | In Vitro Efficacy of Antiviral Compounds against Enterovirus D68. | ||
| Author | Rhoden, Eric; Zhang, Mingyu; Nix, W Allan; Oberste, M Steven | ||
| Journal | Antimicrob Agents Chemother | Publication Year/Month | 2015-Dec |
| PMID | 26149998 | PMCID | PMC4649146 |
| Affiliation + expend | 1.Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. | ||
In 2014, the United States experienced a large outbreak of severe respiratory illness associated with enterovirus D68 (EV-D68). We used a homogeneous, cell-based assay to assess the antiviral activity of compounds developed for EV/rhinovirus infection or other indications. Three of 15 compounds were highly active against all four strains tested (the prototype and three 2014 strains), with 50% effective concentrations of 0.0012 to 0.027 muM. Additional studies are needed to assess their in vivo efficacy against EV-D68.