| Title | Novel triterpene sulfates from Fusarium compactum using a rhinovirus 3C protease inhibitor screen. | ||
| Author | Brill, G M; Kati, W M; Montgomery, D; Karwowski, J P; Humphrey, P E; Jackson, M; Clement, J J; Kadam, S; Chen, R H; McAlpine, J B | ||
| Journal | J Antibiot (Tokyo) | Publication Year/Month | 1996-Jun |
| PMID | 8698636 | PMCID | -N/A- |
| Affiliation | 1.Abbott Laboratories, Abbott Park, Il. 60064, USA. | ||
Two novel triterpene sulfates have been isolated from Fusarium compactum by bioactivity-directed fractionation using an assay which measures the inhibition of proteolytic activity of rhinovirus 3C protease on a fluorogenic peptide substrate. The compounds were purified by countercurrent and reverse phase chromatographies. NMR, MS, UV and IR studies revealed two triterpene sulfates, uncommon metabolites of terrestrial fungi.