PMID Title Journal Publication Year Author View in RVdb
10098667 Design, synthesis, and evaluation of azapeptides as substrates and inhibitors for human rhinovirus 3C protease. Bioorg Med Chem Lett 1999 Venkatraman S;Kong J;Nimkar S;Wang QM;Aube J;Hanzlik RP View More
10197964 Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 3. Structure-activity studies of ketomethylene-containing peptidomimetics. J Med Chem 1999 Dragovich PS;Prins TJ;Zhou R;Fuhrman SA;Patick AK;Matthews DA;Ford CE;Meador JW 3rd;Ferre RA;Worland ST View More
10197965 Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 4. Incorporation of P1 lactam moieties as L-glutamine replacements. J Med Chem 1999 Dragovich PS;Prins TJ;Zhou R;Webber SE;Marakovits JT;Fuhrman SA;Patick AK;Matthews DA;Lee CA;Ford CE;Burke BJ;Rejto PA;Hendrickson TF;Tuntland T;Brown EL;Meador JW 3rd;Ferre RA;Harr JE;Kosa MB;Worland ST View More
10465543 Structure-based design of irreversible, tripeptidyl human rhinovirus 3C protease inhibitors containing N-methyl amino acids. Bioorg Med Chem Lett 1999 Dragovich PS;Webber SE;Prins TJ;Zhou R;Marakovits JT;Tikhe JG;Fuhrman SA;Patick AK;Matthews DA;Ford CE;Brown EL;Binford SL;Meador JW 3rd;Ferre RA;Worland ST View More
10500114 Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes. Proc Natl Acad Sci U S A 1999 Matthews DA;Dragovich PS;Webber SE;Fuhrman SA;Patick AK;Zalman LS;Hendrickson TF;Love RA;Prins TJ;Marakovits JT;Zhou R;Tikhe J;Ford CE;Meador JW;Ferre RA;Brown EL;Binford SL;Brothers MA;DeLisle DM;Worland ST View More
10506239 Lessons learned from a review of the development of selected vaccines. National Vaccine Advisory Committee. Pediatrics 1999 Peter G;des Vignes-Kendrick M;Eickhoff TC;Fine A;Galvin V;Levine MM;Maldonado YA;Marcuse EK;Monath TP;Osborn JE;Plotkin S;Poland GA;Quinlisk MP;Smith DR;Sokol M;Soland DB;Whitley-Williams PN;Williamson DE;Breiman RF View More
10636240 Structure-based design of ketone-containing, tripeptidyl human rhinovirus 3C protease inhibitors. Bioorg Med Chem Lett 2000 Dragovich PS;Zhou R;Webber SE;Prins TJ;Kwok AK;Okano K;Fuhrman SA;Zalman LS;Maldonado FC;Brown EL;Meador JW 3rd;Patick AK;Ford CE;Brothers MA;Binford SL;Matthews DA;Ferre RA;Worland ST View More
10794684 Substituted benzamide inhibitors of human rhinovirus 3C protease: structure-based design, synthesis, and biological evaluation. J Med Chem 2000 Reich SH;Johnson T;Wallace MB;Kephart SE;Fuhrman SA;Worland ST;Matthews DA;Hendrickson TF;Chan F;Meador J 3rd;Ferre RA;Brown EL;DeLisle DM;Patick AK;Binford SL;Ford CE View More
10921773 A novel method of aligning molecules by local surface shape similarity. J Comput Aided Mol Des 2000 Cosgrove DA;Bayada DM;Johnson AP View More
11182317 A structurally biased combinatorial approach for discovering new anti-picornaviral compounds. Chem Biol 2001 Tsang SK;Cheh J;Isaacs L;Joseph-McCarthy D;Choi SK;Pevear DC;Whitesides GM;Hogle JM View More
11750935 Treatment of picornavirus infections. Antiviral Res 2002 Rotbart HA View More
11858991 Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. Part 7: structure-activity studies of bicyclic 2-pyridone-containing peptidomimetics. Bioorg Med Chem Lett 2002 Dragovich PS;Prins TJ;Zhou R;Johnson TO;Brown EL;Maldonado FC;Fuhrman SA;Zalman LS;Patick AK;Matthews DA;Hou X;Meador JW;Ferre RA;Worland ST View More
12133721 Recent advances in the synthesis, design and selection of cysteine protease inhibitors. Curr Opin Chem Biol 2002 Hernandez AA;Roush WR View More
12163617 Genetically stable picornavirus expression vectors with recombinant internal ribosomal entry sites. J Virol 2002 Dufresne AT;Dobrikova EY;Schmidt S;Gromeier M View More
12746549 Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs. Science 2003 Anand K;Ziebuhr J;Wadhwani P;Mesters JR;Hilgenfeld R View More
12838995 Drug Design--SMi Conference. 24-25 February 2003, London, UK. IDrugs 2003 Mackonochie M View More
12944304 Dehydron: a structurally encoded signal for protein interaction. Biophys J 2003 Fernandez A;Scott R View More
12951031 Isolation of a peptide inhibitor of human rhinovirus. Virology 2003 Poritz MA;Malmstrom S;Schmitt A;Kim MK;Zharkikh L;Kamb A;Teng DH View More
1365526 Application of crystallography to the design of antiviral agents. Infect Agents Dis 1992 Rossmann MG;McKinlay MA View More
13678411 Imidazo[1,2-b]pyridazines, novel nucleus with potent and broad spectrum activity against human picornaviruses: design, synthesis, and biological evaluation. J Med Chem 2003 Hamdouchi C;Sanchez-Martinez C;Gruber J;Del Prado M;Lopez J;Rubio A;Heinz BA View More
14521419 Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 8. Pharmacological optimization of orally bioavailable 2-pyridone-containing peptidomimetics. J Med Chem 2003 Dragovich PS;Prins TJ;Zhou R;Johnson TO;Hua Y;Luu HT;Sakata SK;Brown EL;Maldonado FC;Tuntland T;Lee CA;Fuhrman SA;Zalman LS;Patick AK;Matthews DA;Wu EY;Guo M;Borer BC;Nayyar NK;Moran T;Chen L;Rejto PA;Rose PW;Guzman MC;Dovalsantos EZ;Lee S;McGee K;Mohajeri M;Liese A;Tao J;Kosa MB;Liu B;Batugo MR;Gleeson JP;Wu ZP;Liu J;Meador JW 3rd;Ferre RA View More
15080921 Exploring the binding mechanism of the main proteinase in SARS-associated coronavirus and its implication to anti-SARS drug design. Bioorg Med Chem 2004 Zhang XW;Yap YL View More
15320724 Inhibitors of 3C cysteine proteinases from Picornaviridae. Curr Top Med Chem 2004 Lall MS;Jain RP;Vederas JC View More
15615532 Targacept active conformation search: a new method for predicting the conformation of a ligand bound to its protein target. J Med Chem 2004 Klucik J;Xiao YD;Hammond PS;Harris R;Schmitt JD View More
15667141 LigandScout: 3-D pharmacophores derived from protein-bound ligands and their use as virtual screening filters. J Chem Inf Model 2005 Wolber G;Langer T View More
15943481 BRUTUS: optimization of a grid-based similarity function for rigid-body molecular superposition. 1. Alignment and virtual screening applications. J Med Chem 2005 Tervo AJ;Ronkko T;Nyronen TH;Poso A View More
1666824 A comparative test of fifteen compounds against all known human rhinovirus serotypes as a basis for a more rational screening program. Antiviral Res 1991 Andries K;Dewindt B;Snoeks J;Willebrords R;Stokbroekx R;Lewi PJ View More
17305557 Human rhinovirus 3C protease as a potential target for the development of antiviral agents. Curr Protein Pept Sci 2007 Wanga QM;Chen SH View More
18513807 A case for developing antiviral drugs against polio. Antiviral Res 2008 Collett MS;Neyts J;Modlin JF View More
18583140 Design, synthesis, and evaluation of 3C protease inhibitors as anti-enterovirus 71 agents. Bioorg Med Chem 2008 Kuo CJ;Shie JJ;Fang JM;Yen GR;Hsu JT;Liu HG;Tseng SN;Chang SC;Lee CY;Shih SR;Liang PH View More
18840470 New pleconaril and [(biphenyloxy)propyl]isoxazole derivatives with substitutions in the central ring exhibit antiviral activity against pleconaril-resistant coxsackievirus B3. Antiviral Res 2009 Schmidtke M;Wutzler P;Zieger R;Riabova OB;Makarov VA View More
18852005 Deceptive imprinting and immune refocusing in vaccine design. Vaccine 2008 Tobin GJ;Trujillo JD;Bushnell RV;Lin G;Chaudhuri AR;Long J;Barrera J;Pena L;Grubman MJ;Nara PL View More
19026659 In silico vaccine design based on molecular simulations of rhinovirus chimeras presenting HIV-1 gp41 epitopes. J Mol Biol 2009 Lapelosa M;Gallicchio E;Arnold GF;Arnold E;Levy RM View More
19096995 In silico target fishing for rationalized ligand discovery exemplified on constituents of Ruta graveolens. Planta Med 2009 Rollinger JM;Schuster D;Danzl B;Schwaiger S;Markt P;Schmidtke M;Gertsch J;Raduner S;Wolber G;Langer T;Stuppner H View More
20021285 Picornaviral 3C protease inhibitors and the dual 3C protease/coronaviral 3C-like protease inhibitors. Expert Opin Ther Pat 2010 Wang HM;Liang PH View More
20138057 Antigenic characteristics of rhinovirus chimeras designed in silico for enhanced presentation of HIV-1 gp41 epitopes [corrected]. J Mol Biol 2010 Lapelosa M;Arnold GF;Gallicchio E;Arnold E;Levy RM View More
21183345 Non-covalent inhibitors of rhinovirus 3C protease. Bioorg Med Chem Lett 2011 Baxter A;Chambers M;Edfeldt F;Edman K;Freeman A;Johansson C;King S;Morley A;Petersen J;Rawlins P;Spadola L;Thong B;Van de Poel H;Williams N View More
21215622 Pharmacophore-based design, synthesis, and biological evaluation of novel chloro-pyridazine piperazines as human rhinovirus (HRV-3) inhibitors. Bioorg Med Chem Lett 2011 Wang H;Xiao J;Gao D;Zhang X;Yan H;Gong Z;Sun T;Li S View More
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21795339 Enterovirus 71 and coxsackievirus A16 3C proteases: binding to rupintrivir and their substrates and anti-hand, foot, and mouth disease virus drug design. J Virol 2011 Lu G;Qi J;Chen Z;Xu X;Gao F;Lin D;Qian W;Liu H;Jiang H;Yan J;Gao GF View More
22088306 Design, synthesis and in vitro evaluation of novel chroman-4-one, chroman, and 2H-chromene derivatives as human rhinovirus capsid-binding inhibitors. Bioorg Med Chem 2011 Conti C;Proietti Monaco L;Desideri N View More
22926024 Tailored amino acid diversity for the evolution of antibody affinity. MAbs 2012 Gonzalez-Munoz A;Bokma E;O'Shea D;Minton K;Strain M;Vousden K;Rossant C;Jermutus L;Minter R View More
23388726 3C protease of enterovirus 68: structure-based design of Michael acceptor inhibitors and their broad-spectrum antiviral effects against picornaviruses. J Virol 2013 Tan J;George S;Kusov Y;Perbandt M;Anemuller S;Mesters JR;Norder H;Coutard B;Lacroix C;Leyssen P;Neyts J;Hilgenfeld R View More
23726345 Design, synthesis and biological evaluation of novel aminothiazoles as antiviral compounds acting against human rhinovirus. Bioorg Med Chem Lett 2013 Decor A;Grand-Maitre C;Hucke O;O'Meara J;Kuhn C;Constantineau-Forget L;Brochu C;Malenfant E;Bertrand-Laperle M;Bordeleau J;Ghiro E;Pesant M;Fazal G;Gorys V;Little M;Boucher C;Bordeleau S;Turcotte P;Guo T;Garneau M;Spickler C;Gauthier A View More
24125888 Design, synthesis, and bioevaluation of viral 3C and 3C-like protease inhibitors. Bioorg Med Chem Lett 2013 Prior AM;Kim Y;Weerasekara S;Moroze M;Alliston KR;Uy RA;Groutas WC;Chang KO;Hua DH View More
24870364 A fragment-based method to discover irreversible covalent inhibitors of cysteine proteases. J Med Chem 2014 Kathman SG;Xu Z;Statsyuk AV View More
24909291 Do we really need to keep redesigning beta2-agonists for the management of asthma? Curr Drug Deliv 2015 Van Ly D;Oliver BG View More
24973816 Synthesis of new compounds with promising antiviral properties against group A and B Human Rhinoviruses. Bioorg Med Chem 2014 Bernard AM;Cabiddu MG;De Montis S;Mura R;Pompei R View More
25259514 Synthesis and evaluation of 9-deoxy analogues of (-)-thysanone, an inhibitor of HRV 3C protease. Eur J Med Chem 2014 Young Jeong J;Sperry J;Taylor JA;Brimble MA View More
25350699 Novel prodrug-like fusion toxin with protease-sensitive bioorthogonal PEGylation for tumor targeting. Bioconjug Chem 2014 Stefan N;Zimmermann M;Simon M;Zangemeister-Wittke U;Pluckthun A View More
27265257 Design and structure-activity relationships of novel inhibitors of human rhinovirus 3C protease. Bioorg Med Chem Lett 2016 Kawatkar SP;Gagnon M;Hoesch V;Tiong-Yip C;Johnson K;Ek M;Nilsson E;Lister T;Olsson L;Patel J;Yu Q View More
28004945 Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4-Kinase IIIbeta (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology. J Med Chem 2017 Mejdrova I;Chalupska D;Plackova P;Muller C;Sala M;Klima M;Baumlova A;Hrebabecky H;Prochazkova E;Dejmek M;Strunin D;Weber J;Lee G;Matousova M;Mertlikova-Kaiserova H;Ziebuhr J;Birkus G;Boura E;Nencka R View More
28778471 Design, synthesis and evaluation of 2,2-dimethyl-1,3-dioxolane derivatives as human rhinovirus 3C protease inhibitors. Bioorg Med Chem Lett 2017 Zhang Q;Cao R;Liu A;Lei S;Li Y;Yang J;Li S;Xiao J View More
29433930 Structure-based design and synthesis of macrocyclic human rhinovirus 3C protease inhibitors. Bioorg Med Chem Lett 2018 Namoto K;Sirockin F;Sellner H;Wiesmann C;Villard F;Moreau RJ;Valeur E;Paulding SC;Schleeger S;Schipp K;Loup J;Andrews L;Swale R;Robinson M;Farady CJ View More
30153009 Structure-Based Drug Design of Potent Pyrazole Derivatives against Rhinovirus Replication. J Med Chem 2018 Da Costa L;Scheers E;Coluccia A;Casulli A;Roche M;Di Giorgio C;Neyts J;Terme T;Cirilli R;La Regina G;Silvestri R;Mirabelli C;Vanelle P View More
30646829 Good and bad molecular fingerprints for human rhinovirus 3C protease inhibition: identification, validation, and application in designing of new inhibitors through Monte Carlo-based QSAR study. J Biomol Struct Dyn 2020 Jain S;Amin SA;Adhikari N;Jha T;Gayen S View More
30844608 New 4-phenylcoumarin derivatives as potent 3C protease inhibitors: Design, synthesis, anti-HAV effect and molecular modeling. Eur J Med Chem 2019 Kassem AF;Batran RZ;Abbas EMH;Elseginy SA;Shaheen MNF;Elmahdy EM View More
31416365 Overview of human rhinovirus immunogenic epitopes for rational vaccine design. Expert Rev Vaccines 2019 Stepanova E;Isakova-Sivak I;Rudenko L View More
32103448 Structure of the HRV-C 3C-Rupintrivir Complex Provides New Insights for Inhibitor Design. Virol Sin 2020 Yuan S;Fan K;Chen Z;Sun Y;Hou H;Zhu L View More
32568687 COVID-19 Coronavirus spike protein analysis for synthetic vaccines, a peptidomimetic antagonist, and therapeutic drugs, and analysis of a proposed achilles\' heel conserved region to minimize probability of escape mutations and drug resistance. Comput Biol Med 2020 Robson B View More
33356169 Rationally Designed ACE2-Derived Peptides Inhibit SARS-CoV-2. Bioconjug Chem 2021 Larue RC;Xing E;Kenney AD;Zhang Y;Tuazon JA;Li J;Yount JS;Li PK;Sharma A View More
33872498 Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2. J Med Chem 2022 Dai W;Jochmans D;Xie H;Yang H;Li J;Su H;Chang D;Wang J;Peng J;Zhu L;Nian Y;Hilgenfeld R;Jiang H;Chen K;Zhang L;Xu Y;Neyts J;Liu H View More
37030533 Computer-aided drug design in seeking viral capsid modulators. Drug Discov Today 2023 Zhao S;Zhang X;da Silva-Junior EF;Zhan P;Liu X View More
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9888832 2-Amino-3-substituted-6-[(E)-1-phenyl-2-(N-methylcarbamoyl)vinyl]imid azo[1,2-a]pyridines as a novel class of inhibitors of human rhinovirus: stereospecific synthesis and antiviral activity. J Med Chem 1999 Hamdouchi C;de Blas J;del Prado M;Gruber J;Heinz BA;Vance L View More