PMID Title Journal Publication Year Author View in RVdb
10669262 Inhibitory effect of dibenzofuran and dibenzosuberol derivatives on rhinovirus replication in vitro; effective prevention of viral entry by dibenzosuberenone. Antiviral Res 1999 Murray MA;Babe LM View More
10999479 S-nitrosothiols as novel, reversible inhibitors of human rhinovirus 3C protease. Bioorg Med Chem Lett 2000 Xian M;Wang QM;Chen X;Wang K;Wang PG View More
11159387 Molecular dynamics simulations of human rhinovirus and an antiviral compound. Biophys J 2001 Speelman B;Brooks BR;Post CB View More
11750935 Treatment of picornavirus infections. Antiviral Res 2002 Rotbart HA View More
11900346 Peptidyl diazomethyl ketones inhibit the human rhinovirus 3C protease: effect on virus yield by partial block of P3 polyprotein processing. Antivir Chem Chemother 2001 Murray MA;Janc JW;Venkatraman S;Babe LM View More
12413027 Motion of an antiviral compound in a rhinovirus capsid under rotational symmetry boundary conditions. J Mol Graph Model 2002 Yoneda S;Yoneda T;Kurihara Y;Umeyama H View More
12515488 Virus-ligand interactions: identification and characterization of ligand binding by NMR spectroscopy. J Am Chem Soc 2003 Benie AJ;Moser R;Bauml E;Blaas D;Peters T View More
1318383 Binding of an antiviral agent to a sensitive and a resistant human rhinovirus. Computer simulation studies with sampling of amino acid side-chain conformation. I. Mapping the rotamers of residue 188 of viral protein 1. J Mol Biol 1992 Wade RC;McCammon JA View More
1318384 Binding of an antiviral agent to a sensitive and a resistant human rhinovirus. Computer simulation studies with sampling of amino acid side-chain conformations. II. Calculation of free-energy differences by thermodynamic integration. J Mol Biol 1992 Wade RC;McCammon JA View More
15080921 Exploring the binding mechanism of the main proteinase in SARS-associated coronavirus and its implication to anti-SARS drug design. Bioorg Med Chem 2004 Zhang XW;Yap YL View More
15168800 Mode of action of 2-furylmercury chloride, an anti-rhinovirus compound. Antiviral Res 2004 Verheyden B;Andries K;Rombaut B View More
15667141 LigandScout: 3-D pharmacophores derived from protein-bound ligands and their use as virtual screening filters. J Chem Inf Model 2005 Wolber G;Langer T View More
15825420 In vitro antiviral activity of 6-substituted 9-beta-D-ribofuranosylpurine 3\', 5\'-cyclic phosphates. Antimicrob Agents Chemother 1974 Sidwell RW;Huffman JH;Allen LB;Meyer RB Jr;Shuman DA;Simon LN;Robins RK View More
1654576 Structure and in vitro antiviral activity of triterpenoid saponins from Calendula arvensis. Planta Med 1991 De Tommasi N;Conti C;Stein ML;Pizza C View More
17357972 Antiviral triterpenoids from the medicinal plant Schefflera heptaphylla. Phytother Res 2007 Li Y;Jiang R;Ooi LS;But PP;Ooi VE View More
1847215 Human rhinovirus 14 complexed with antiviral compound R 61837. J Mol Biol 1991 Chapman MS;Minor I;Rossmann MG;Diana GD;Andries K View More
19097770 Antiviral activity of raoulic acid from Raoulia australis against Picornaviruses. Phytomedicine 2009 Choi HJ;Lim CH;Song JH;Baek SH;Kwon DH View More
19237651 Mutations in the nonstructural protein 3A confer resistance to the novel enterovirus replication inhibitor TTP-8307. Antimicrob Agents Chemother 2009 De Palma AM;Thibaut HJ;van der Linden L;Lanke K;Heggermont W;Ireland S;Andrews R;Arimilli M;Al-Tel TH;De Clercq E;van Kuppeveld F;Neyts J View More
20380638 Biological activities of 2-styrylchromones. Mini Rev Med Chem 2010 Gomes A;Freitas M;Fernandes E;Lima JL View More
21183345 Non-covalent inhibitors of rhinovirus 3C protease. Bioorg Med Chem Lett 2011 Baxter A;Chambers M;Edfeldt F;Edman K;Freeman A;Johansson C;King S;Morley A;Petersen J;Rawlins P;Spadola L;Thong B;Van de Poel H;Williams N View More
21795339 Enterovirus 71 and coxsackievirus A16 3C proteases: binding to rupintrivir and their substrates and anti-hand, foot, and mouth disease virus drug design. J Virol 2011 Lu G;Qi J;Chen Z;Xu X;Gao F;Lin D;Qian W;Liu H;Jiang H;Yan J;Gao GF View More
21835784 Structural basis for antiviral inhibition of the main protease, 3C, from human enterovirus 93. J Virol 2011 Costenaro L;Kaczmarska Z;Arnan C;Janowski R;Coutard B;Sola M;Gorbalenya AE;Norder H;Canard B;Coll M View More
22486038 Chemical and antiviral study on alkaloids from Papaver pseudocanescens M. Pop. Z Naturforsch C J Biosci 2012 Istatkova R;Nikolaeva-Glomb L;Galabov A;Yadamsuren GO;Samdan J;Dangaa S;Philipov S View More
23170079 Anti-human rhinoviral activity of polybromocatechol compounds isolated from the rhodophyta, Neorhodomela aculeata. Mar Drugs 2012 Park SH;Song JH;Kim T;Shin WS;Park GM;Lee S;Kim YJ;Choi P;Kim H;Kim HS;Kwon DH;Choi HJ;Ham J View More
23201315 Novel polymeric inhibitors of HCoV-NL63. Antiviral Res 2013 Milewska A;Ciejka J;Kaminski K;Karewicz A;Bielska D;Zeglen S;Karolak W;Nowakowska M;Potempa J;Bosch BJ;Pyrc K;Szczubialka K View More
23388726 3C protease of enterovirus 68: structure-based design of Michael acceptor inhibitors and their broad-spectrum antiviral effects against picornaviruses. J Virol 2013 Tan J;George S;Kusov Y;Perbandt M;Anemuller S;Mesters JR;Norder H;Coutard B;Lacroix C;Leyssen P;Neyts J;Hilgenfeld R View More
23403777 Antiviral activity of Isatis indigotica root-derived clemastanin B against human and avian influenza A and B viruses in vitro. Int J Mol Med 2013 Yang Z;Wang Y;Zheng Z;Zhao S;Zhao J;Lin Q;Li C;Zhu Q;Zhong N View More
24314639 Modeling of the human rhinovirus C capsid suggests possible causes for antiviral drug resistance. Virology 2014 Basta HA;Ashraf S;Sgro JY;Bochkov YA;Gern JE;Palmenberg AC View More
24521134 Recent developments in antiviral agents against enterovirus 71 infection. J Biomed Sci 2014 Tan CW;Lai JK;Sam IC;Chan YF View More
24948704 A novel benzonitrile analogue inhibits rhinovirus replication. J Antimicrob Chemother 2014 Lacroix C;Querol-Audi J;Roche M;Franco D;Froeyen M;Guerra P;Terme T;Vanelle P;Verdaguer N;Neyts J;Leyssen P View More
25076758 [Preclinical study of AV0012 early stage inhibitor of hepatitis C virus infection: I. In vitro ADME and pharmacokinetics]. Eksp Klin Farmakol 2014 Ivashchenko AV;Iamanushkin PM;Mit'kin OD;Ezhova EV;Korzinov OM;Shevkun NA;Koriakova AG;Karapetian RN;Bychko VV;Ivashchenko AA;Agrba VZ;Lapin BA;Orlov SV View More
25792507 Peptidomimetic ethyl propenoate covalent inhibitors of the enterovirus 71 3C protease: a P2-P4 study. J Enzyme Inhib Med Chem 2016 Ang MJ;Lau QY;Ng FM;Then SW;Poulsen A;Cheong YK;Ngoh ZX;Tan YW;Peng J;Keller TH;Hill J;Chu JJ;Chia CS View More
25860871 Antiviral activity and possible mechanism of action of constituents identified in Paeonia lactiflora root toward human rhinoviruses. PLoS One 2015 Ngan LT;Jang MJ;Kwon MJ;Ahn YJ View More
26055377 The enterovirus 3C protease inhibitor SG85 efficiently blocks rhinovirus replication and is not cross-resistant with rupintrivir. Antimicrob Agents Chemother 2015 Lacroix C;George S;Leyssen P;Hilgenfeld R;Neyts J View More
26494169 Murine norovirus (MNV-1) exposure in vitro to the purine nucleoside analog Ribavirin increases quasispecies diversity. Virus Res 2016 Julian TR;Baugher JD;Rippinger CM;Pinekenstein R;Kolawole AO;Mehoke TS;Wobus CE;Feldman AB;Pineda FJ;Schwab KJ View More
27645381 Antiviral activities of peptide-based covalent inhibitors of the Enterovirus 71 3C protease. Sci Rep 2016 Tan YW;Ang MJ;Lau QY;Poulsen A;Ng FM;Then SW;Peng J;Hill J;Hong WJ;Chia CS;Chu JJ View More
27647011 Antiviral activities of compounds from aerial parts of Salvia plebeia R. Br. J Ethnopharmacol 2016 Bang S;Quy Ha TK;Lee C;Li W;Oh WK;Shim SH View More
28242170 3-Phenylalkyl-2H-chromenes and -chromans as novel rhinovirus infection inhibitors. Bioorg Med Chem 2017 Conti C;Proietti Monaco L;Desideri N View More
28546965 Ribonuclease from Bacillus Acts as an Antiviral Agent against Negative- and Positive-Sense Single Stranded Human Respiratory RNA Viruses. Biomed Res Int 2017 Shah Mahmud R;Muller C;Romanova Y;Mostafa A;Ulyanova V;Pleschka S;Ilinskaya O View More
28914420 Labdane-type diterpenoids from Vitex limonifolia and their antivirus activities. J Nat Med 2018 Ban NK;Thoa NTK;Linh TM;Trang DT;Van Kiem P;Nhiem NX;Tai BH;Van Minh C;Song JH;Ko HJ;Kim SH View More
28987610 Heterocyclic pharmacochemistry of new rhinovirus antiviral agents: A combined computational and experimental study. Eur J Med Chem 2017 Da Costa L;Scheers E;Coluccia A;Rosetti A;Roche M;Neyts J;Terme T;Cirilli R;Mirabelli C;Silvestri R;Vanelle P View More
29039946 Phenylpropenoids from Bupleurum fruticosum as Anti-Human Rhinovirus Species A Selective Capsid Binders. J Nat Prod 2017 Fois B;Bianco G;Sonar VP;Distinto S;Maccioni E;Meleddu R;Melis C;Marras L;Pompei R;Floris C;Caboni P;Cottiglia F View More
29554706 Discovery of Bioactive Natural Products for the Treatment of Acute Respiratory Infections - An Integrated Approach. Planta Med 2018 Grienke U;Mair CE;Kirchmair J;Schmidtke M;Rollinger JM View More
29562753 Nucleosides for the treatment of respiratory RNA virus infections. Antivir Chem Chemother 2018 Jordan PC;Stevens SK;Deval J View More
29760414 Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus. Nat Chem 2018 Mousnier A;Bell AS;Swieboda DP;Morales-Sanfrutos J;Perez-Dorado I;Brannigan JA;Newman J;Ritzefeld M;Hutton JA;Guedan A;Asfor AS;Robinson SW;Hopkins-Navratilova I;Wilkinson AJ;Johnston SL;Leatherbarrow RJ;Tuthill TJ;Solari R;Tate EW View More
30037024 Effect of Tea Catechins on Influenza Infection and the Common Cold with a Focus on Epidemiological/Clinical Studies. Molecules 2018 Furushima D;Ide K;Yamada H View More
30352199 Development of a homogeneous time-resolved fluorescence assay for detection of viral double-stranded RNA. Anal Biochem 2019 Fujita M;Adachi K;Nagasawa M View More
30646829 Good and bad molecular fingerprints for human rhinovirus 3C protease inhibition: identification, validation, and application in designing of new inhibitors through Monte Carlo-based QSAR study. J Biomol Struct Dyn 2020 Jain S;Amin SA;Adhikari N;Jha T;Gayen S View More
30668313 In vivo effect of quantified flavonoids-enriched extract of Scutellaria baicalensis root on acute lung injury induced by influenza A virus. Phytomedicine 2019 Zhi HJ;Zhu HY;Zhang YY;Lu Y;Li H;Chen DF View More
30707726 Pelargonium sidoides radix extract EPs 7630 reduces rhinovirus infection through modulation of viral binding proteins on human bronchial epithelial cells. PLoS One 2019 Roth M;Fang L;Stolz D;Tamm M View More
31203807 Thiazole Compounds as Antiviral Agents: An Update. Med Chem 2020 Singh IP;Gupta S;Kumar S View More
31226653 Back to the future: Advances in development of broad-spectrum capsid-binding inhibitors of enteroviruses. Eur J Med Chem 2019 Egorova A;Ekins S;Schmidtke M;Makarov V View More
32467165 Inhibitory antibodies identify unique sites of therapeutic vulnerability in rhinovirus and other enteroviruses. Proc Natl Acad Sci U S A 2020 Meng B;Lan K;Xie J;Lerner RA;Wilson IA;Yang B View More
32843628 A broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2. Nat Commun 2020 Zhao H;To KKW;Sze KH;Yung TT;Bian M;Lam H;Yeung ML;Li C;Chu H;Yuen KY View More
33444702 Inhibition of coronavirus infection by a synthetic STING agonist in primary human airway system. Antiviral Res 2021 Zhu Q;Zhang Y;Wang L;Yao X;Wu D;Cheng J;Pan X;Liu H;Yan Z;Gao L View More
33515606 Dual inhibition of SARS-CoV-2 and human rhinovirus with protease inhibitors in clinical development. Antiviral Res 2021 Liu C;Boland S;Scholle MD;Bardiot D;Marchand A;Chaltin P;Blatt LM;Beigelman L;Symons JA;Raboisson P;Gurard-Levin ZA;Vandyck K;Deval J View More
33641023 Structure-activity relationship (SAR) and molecular dynamics study of withaferin-A fragment derivatives as potential therapeutic lead against main protease (M(pro)) of SARS-CoV-2. J Mol Model 2021 Ghosh A;Chakraborty M;Chandra A;Alam MP View More
33969451 Design of fusion protein for efficient preparation of cyanovirin-n and rapid enrichment of pseudorabies virus. Biotechnol Lett 2021 Wang B;Yang Z;Gao D;Wang F;Liu M;Chen G;Ma L;Yu X View More
34285133 Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2. Science 2021 Drayman N;DeMarco JK;Jones KA;Azizi SA;Froggatt HM;Tan K;Maltseva NI;Chen S;Nicolaescu V;Dvorkin S;Furlong K;Kathayat RS;Firpo MR;Mastrodomenico V;Bruce EA;Schmidt MM;Jedrzejczak R;Munoz-Alia MA;Schuster B;Nair V;Han KY;O'Brien A;Tomatsidou A;Meyer B;Vignuzzi M;Missiakas D;Botten JW;Brooke CB;Lee H;Baker SC;Mounce BC;Heaton NS;Severson WE;Palmer KE;Dickinson BC;Joachimiak A;Randall G;Tay S View More
34382337 Bithiazole Inhibitors of Phosphatidylinositol 4-Kinase (PI4KIIIbeta) as Broad-Spectrum Antivirals Blocking the Replication of SARS-CoV-2, Zika Virus, and Human Rhinoviruses. ChemMedChem 2021 Grazia Martina M;Vicenti I;Bauer L;Crespan E;Rango E;Boccuto A;Olivieri N;Incerti M;Zwaagstra M;Allodi M;Bertoni S;Dreassi E;Zazzi M;van Kuppeveld FJM;Maga G;Radi M View More
34506130 Pan-3C Protease Inhibitor Rupintrivir Binds SARS-CoV-2 Main Protease in a Unique Binding Mode. Biochemistry 2021 Lockbaum GJ;Henes M;Lee JM;Timm J;Nalivaika EA;Thompson PR;Kurt Yilmaz N;Schiffer CA View More
34619630 Viral polymerase binding and broad-spectrum antiviral activity of molnupiravir against human seasonal coronaviruses. Virology 2021 Wang Y;Li P;Solanki K;Li Y;Ma Z;Peppelenbosch MP;Baig MS;Pan Q View More
34681727 Promising Antiviral Activities of Natural Flavonoids against SARS-CoV-2 Targets: Systematic Review. Int J Mol Sci 2021 Kaul R;Paul P;Kumar S;Busselberg D;Dwivedi VD;Chaari A View More
34960671 RIPK1 Is Cleaved by 3C Protease of Rhinovirus A and B Strains and Minor and Major Groups. Viruses 2021 Croft SN;Walker EJ;Ghildyal R View More
35278580 Label-free duplex SAMDI-MS screen reveals novel SARS-CoV-2 3CLpro inhibitors. Antiviral Res 2022 Scholle MD;O'Kane PT;Dib S;Gurard-Levin ZA View More
35292344 Enteroviral replication inhibition by N-Alkyl triazolopyrimidinone derivatives through a non-capsid binding mode. Bioorg Med Chem Lett 2022 Kumar Biswas B;Soo Shin J;Malpani YR;Hwang D;Jung E;Bong Han S;Vishakantegowda AG;Jung YS View More
35504537 EV71 3C protease cleaves host anti-viral factor OAS3 and enhances virus replication. Virol Sin 2022 Zhou X;Tian L;Wang J;Zheng B;Zhang W View More
36615554 The Effects of Propolis on Viral Respiratory Diseases. Molecules 2023 Ozarowski M;Karpinski TM View More
7629816 [(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors. J Med Chem 1995 Guiles JW;Diana GD;Pevear DC View More
7731021 Picornavirus inhibitors: trifluoromethyl substitution provides a global protective effect against hepatic metabolism. J Med Chem 1995 Diana GD;Rudewicz P;Pevear DC;Nitz TJ;Aldous SC;Aldous DJ;Robinson DT;Draper T;Dutko FJ;Aldi C;et al. View More
7741522 SDZ 35-682, a new picornavirus capsid-binding agent with potent antiviral activity. Antiviral Res 1995 Rosenwirth B;Oren DA;Arnold E;Kis ZL;Eggers HJ View More
7820548 Structures of poliovirus complexes with anti-viral drugs: implications for viral stability and drug design. Curr Biol 1994 Grant RA;Hiremath CN;Filman DJ;Syed R;Andries K;Hogle JM View More
7919786 Protein structure--based drug design. Annu Rev Biophys Biomol Struct 1994 Whittle PJ;Blundell TL View More
8057290 Oxadiazoles as ester bioisosteric replacements in compounds related to disoxaril. Antirhinovirus activity. J Med Chem 1994 Diana GD;Volkots DL;Nitz TJ;Bailey TR;Long MA;Vescio N;Aldous S;Pevear DC;Dutko FJ View More
8071130 Citrinin hydrate and radicinin: human rhinovirus 3C-protease inhibitors discovered in a target-directed microbial screen. J Antibiot (Tokyo) 1994 Kadam S;Poddig J;Humphrey P;Karwowski J;Jackson M;Tennent S;Fung L;Hochlowski J;Rasmussen R;McAlpine J View More
8380615 On the prediction of binding properties of drug molecules by comparative molecular field analysis. J Med Chem 1993 Klebe G;Abraham U View More
8787122 Crystallographers pinpoint what goes where. Science 1996 Service RF View More
8939746 Human rhinovirus 3 at 3.0 A resolution. Structure 1996 Zhao R;Pevear DC;Kremer MJ;Giranda VL;Kofron JA;Kuhn RJ;Rossmann MG View More
9512706 Influence of an antiviral compound on the temperature dependence of viral protein flexibility and packing: a molecular dynamics study. J Mol Biol 1998 Phelps DK;Rossky PJ;Post CB View More