| Title | Back to the future: Advances in development of broad-spectrum capsid-binding inhibitors of enteroviruses. | ||
| Author | Egorova, Anna; Ekins, Sean; Schmidtke, Michaela; Makarov, Vadim | ||
| Journal | Eur J Med Chem | Publication Year/Month | 2019-Sep |
| PMID | 31226653 | PMCID | PMC8194503 |
| Affiliation + expend | 1.Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Leninsky prospekt 33-2, Moscow, 119071, Russia. | ||
The hydrophobic pocket within viral capsid protein 1 is a target to combat the rhino- and enteroviruses (RV and EV) using small molecules. The highly conserved amino acids lining this pocket enable the development of antivirals with broad-spectrum of activity against numerous RVs and EVs. Inhibitor binding blocks: the attachment of the virion to the host cell membrane, viral uncoating, and/or production of infectious virus particles. Syntheses and biological studies of the most well-known antipicornaviral capsid binders have been reviewed and we propose next steps in this research.