10197965
|
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 4. Incorporation of P1 lactam moieties as L-glutamine replacements. |
J Med Chem |
1999 |
Dragovich PS;Prins TJ;Zhou R;Webber SE;Marakovits JT;Fuhrman SA;Patick AK;Matthews DA;Lee CA;Ford CE;Burke BJ;Rejto PA;Hendrickson TF;Tuntland T;Brown EL;Meador JW 3rd;Ferre RA;Harr JE;Kosa MB;Worland ST |
View
More |
10500114
|
Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes. |
Proc Natl Acad Sci U S A |
1999 |
Matthews DA;Dragovich PS;Webber SE;Fuhrman SA;Patick AK;Zalman LS;Hendrickson TF;Love RA;Prins TJ;Marakovits JT;Zhou R;Tikhe J;Ford CE;Meador JW;Ferre RA;Brown EL;Binford SL;Brothers MA;DeLisle DM;Worland ST |
View
More |
10508022
|
In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease. |
Antimicrob Agents Chemother |
1999 |
Patick AK;Binford SL;Brothers MA;Jackson RL;Ford CE;Diem MD;Maldonado F;Dragovich PS;Zhou R;Prins TJ;Fuhrman SA;Meador JW;Zalman LS;Matthews DA;Worland ST |
View
More |
10595531
|
Molecular dynamics investigation of the effect of an antiviral compound on human rhinovirus. |
Protein Sci |
1999 |
Phelps DK;Post CB |
View
More |
10611281
|
Analysis of three structurally related antiviral compounds in complex with human rhinovirus 16. |
Proc Natl Acad Sci U S A |
1999 |
Hadfield AT;Diana GD;Rossmann MG |
View
More |
10770757
|
Inhibition of human rhinovirus-induced cytokine production by AG7088, a human rhinovirus 3C protease inhibitor. |
Antimicrob Agents Chemother |
2000 |
Zalman LS;Brothers MA;Dragovich PS;Zhou R;Prins TJ;Worland ST;Patick AK |
View
More |
10782382
|
Disoxaril-related 3-(diethylamino)-5-phenylisoxazoles. |
Farmaco |
2000 |
Mazzei M;Dondero R;Ledda B;Demontis F;Vargiu L |
View
More |
10974374
|
In vitro activity of pleconaril and AG7088 against selected serotypes and clinical isolates of human rhinoviruses. |
Antiviral Res |
2000 |
Kaiser L;Crump CE;Hayden FG |
View
More |
11159387
|
Molecular dynamics simulations of human rhinovirus and an antiviral compound. |
Biophys J |
2001 |
Speelman B;Brooks BR;Post CB |
View
More |
11166856
|
The treatment of rhinovirus infections: progress and potential. |
Antiviral Res |
2001 |
Turner RB |
View
More |
11249711
|
AG-7088 Pfizer. |
Curr Opin Investig Drugs |
2000 |
Witherell G |
View
More |
11302940
|
Liquid chromatography-mass spectrometry and liquid chromatography-NMR characterization of in vitro metabolites of a potent and irreversible peptidomimetic inhibitor of rhinovirus 3C protease. |
Drug Metab Dispos |
2001 |
Zhang KE;Hee B;Lee CA;Liang B;Potts BC |
View
More |
11796347
|
Pharmacokinetics and safety of an antirhinoviral agent, ruprintrivir, in healthy volunteers. |
Antimicrob Agents Chemother |
2002 |
Hsyu PH;Pithavala YK;Gersten M;Penning CA;Kerr BM |
View
More |
11920874
|
Kinetics of thermal denaturation of human rhinoviruses in the presence of anti-viral capsid binders analyzed by capillary electrophoresis. |
Electrophoresis |
2002 |
Okun VM;Nizet S;Blaas D;Kenndler E |
View
More |
12413027
|
Motion of an antiviral compound in a rhinovirus capsid under rotational symmetry boundary conditions. |
J Mol Graph Model |
2002 |
Yoneda S;Yoneda T;Kurihara Y;Umeyama H |
View
More |
12515488
|
Virus-ligand interactions: identification and characterization of ligand binding by NMR spectroscopy. |
J Am Chem Soc |
2003 |
Benie AJ;Moser R;Bauml E;Blaas D;Peters T |
View
More |
12743280
|
Human rhinovirus type 16: mutant V1210A requires capsid-binding drug for assembly of pentamers to form virions during morphogenesis. |
J Virol |
2003 |
Lee WM;Wang W |
View
More |
12746549
|
Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs. |
Science |
2003 |
Anand K;Ziebuhr J;Wadhwani P;Mesters JR;Hilgenfeld R |
View
More |
1313108
|
CoMFA analysis of the interactions of antipicornavirus compounds in the binding pocket of human rhinovirus-14. |
J Med Chem |
1992 |
Diana GD;Kowalczyk P;Treasurywala AM;Oglesby RC;Pevear DC;Dutko FJ |
View
More |
1335079
|
Antirhinoviral activity of heterocyclic analogs of Win 54954. |
J Med Chem |
1992 |
Bailey TR;Diana GD;Kowalczyk PJ;Akullian V;Eissenstat MA;Cutcliffe D;Mallamo JP;Carabateas PM;Pevear DC |
View
More |
1335081
|
Conformationally restricted analogues of disoxaril: a comparison of the activity against human rhinovirus types 14 and 1A. |
J Med Chem |
1992 |
Mallamo JP;Diana GD;Pevear DC;Dutko FJ;Chapman MS;Kim KH;Minor I;Oliveira M;Rossmann MG |
View
More |
14517058
|
Human rhinovirus capsid dynamics is controlled by canyon flexibility. |
Virology |
2003 |
Reisdorph N;Thomas JJ;Katpally U;Chase E;Harris K;Siuzdak G;Smith TJ |
View
More |
14638501
|
Phase II, randomized, double-blind, placebo-controlled studies of ruprintrivir nasal spray 2-percent suspension for prevention and treatment of experimentally induced rhinovirus colds in healthy volunteers. |
Antimicrob Agents Chemother |
2003 |
Hayden FG;Turner RB;Gwaltney JM;Chi-Burris K;Gersten M;Hsyu P;Patick AK;Smith GJ 3rd;Zalman LS |
View
More |
15673742
|
Conservation of amino acids in human rhinovirus 3C protease correlates with broad-spectrum antiviral activity of rupintrivir, a novel human rhinovirus 3C protease inhibitor. |
Antimicrob Agents Chemother |
2005 |
Binford SL;Maldonado F;Brothers MA;Weady PT;Zalman LS;Meador JW 3rd;Matthews DA;Patick AK |
View
More |
15743897
|
Novel [(biphenyloxy)propyl]isoxazole derivatives for inhibition of human rhinovirus 2 and coxsackievirus B3 replication. |
J Antimicrob Chemother |
2005 |
Makarov VA;Riabova OB;Granik VG;Wutzler P;Schmidtke M |
View
More |
15899980
|
Dissociation of an antiviral compound from the internal pocket of human rhinovirus 14 capsid. |
Proc Natl Acad Sci U S A |
2005 |
Li Y;Zhou Z;Post CB |
View
More |
15944313
|
The role of p38 MAPK in rhinovirus-induced monocyte chemoattractant protein-1 production by monocytic-lineage cells. |
J Immunol |
2005 |
Hall DJ;Bates ME;Guar L;Cronan M;Korpi N;Bertics PJ |
View
More |
16387393
|
Physico-chemical characterization of disoxaril-dimethyl-beta-cyclodextrin inclusion complex and in vitro permeation studies. |
Eur J Med Chem |
2006 |
Ventura CA;Giannone I;Musumeci T;Pignatello R;Ragni L;Landolfi C;Milanese C;Paolino D;Puglisi G |
View
More |
1656851
|
Binding affinities of structurally related human rhinovirus capsid-binding compounds are related to their activities against human rhinovirus type 14. |
Antimicrob Agents Chemother |
1991 |
Fox MP;McKinlay MA;Diana GD;Dutko FJ |
View
More |
1666824
|
A comparative test of fifteen compounds against all known human rhinovirus serotypes as a basis for a more rational screening program. |
Antiviral Res |
1991 |
Andries K;Dewindt B;Snoeks J;Willebrords R;Stokbroekx R;Lewi PJ |
View
More |
17161425
|
VP4 protein from human rhinovirus 14 is released by pressure and locked in the capsid by the antiviral compound WIN. |
J Mol Biol |
2007 |
Goncalves RB;Mendes YS;Soares MR;Katpally U;Smith TJ;Silva JL;Oliveira AC |
View
More |
17428846
|
Pocket factors are unlikely to play a major role in the life cycle of human rhinovirus. |
J Virol |
2007 |
Katpally U;Smith TJ |
View
More |
17485072
|
Development of potent inhibitors of the coxsackievirus 3C protease. |
Biochem Biophys Res Commun |
2007 |
Lee ES;Lee WG;Yun SH;Rho SH;Im I;Yang ST;Sellamuthu S;Lee YJ;Kwon SJ;Park OK;Jeon ES;Park WJ;Kim YC |
View
More |
17665898
|
Quantitative structure-activity relationship studies of [(biphenyloxy)propyl]isoxazole derivatives. Inhibitors of human rhinovirus 2 replication. |
J Med Chem |
2007 |
Kuz'min VE;Artemenko AG;Muratov EN;Volineckaya IL;Makarov VA;Riabova OB;Wutzler P;Schmidtke M |
View
More |
17908951
|
In vitro resistance study of rupintrivir, a novel inhibitor of human rhinovirus 3C protease. |
Antimicrob Agents Chemother |
2007 |
Binford SL;Weady PT;Maldonado F;Brothers MA;Matthews DA;Patick AK |
View
More |
1847178
|
Stabilization of human rhinovirus serotype 2 against pH-induced conformational change by antiviral compounds. |
J Gen Virol |
1991 |
Gruenberger M;Pevear D;Diana GD;Kuechler E;Blaas D |
View
More |
18840470
|
New pleconaril and [(biphenyloxy)propyl]isoxazole derivatives with substitutions in the central ring exhibit antiviral activity against pleconaril-resistant coxsackievirus B3. |
Antiviral Res |
2009 |
Schmidtke M;Wutzler P;Zieger R;Riabova OB;Makarov VA |
View
More |
20066739
|
Rupintrivir is a promising candidate for treating severe cases of Enterovirus-71 infection. |
World J Gastroenterol |
2010 |
Zhang XN;Song ZG;Jiang T;Shi BS;Hu YW;Yuan ZH |
View
More |
2158559
|
A model for compounds active against human rhinovirus-14 based on X-ray crystallography data. |
J Med Chem |
1990 |
Diana GD;Treasurywala AM;Bailey TR;Oglesby RC;Pevear DC;Dutko FJ |
View
More |
21795339
|
Enterovirus 71 and coxsackievirus A16 3C proteases: binding to rupintrivir and their substrates and anti-hand, foot, and mouth disease virus drug design. |
J Virol |
2011 |
Lu G;Qi J;Chen Z;Xu X;Gao F;Lin D;Qian W;Liu H;Jiang H;Yan J;Gao GF |
View
More |
21813612
|
Crystal structures of enterovirus 71 3C protease complexed with rupintrivir reveal the roles of catalytically important residues. |
J Virol |
2011 |
Wang J;Fan T;Yao X;Wu Z;Guo L;Lei X;Wang J;Wang M;Jin Q;Cui S |
View
More |
21835784
|
Structural basis for antiviral inhibition of the main protease, 3C, from human enterovirus 93. |
J Virol |
2011 |
Costenaro L;Kaczmarska Z;Arnan C;Janowski R;Coutard B;Sola M;Gorbalenya AE;Norder H;Canard B;Coll M |
View
More |
23295352
|
Rupintrivir is a promising candidate for treating severe cases of enterovirus-71 infection: evaluation of antiviral efficacy in a murine infection model. |
Antiviral Res |
2013 |
Zhang X;Song Z;Qin B;Zhang X;Chen L;Hu Y;Yuan Z |
View
More |
23549610
|
The newly emerged SARS-like coronavirus HCoV-EMC also has an "Achilles\' heel": current effective inhibitor targeting a 3C-like protease. |
Protein Cell |
2013 |
Ren Z;Yan L;Zhang N;Guo Y;Yang C;Lou Z;Rao Z |
View
More |
23633597
|
Structures of Enterovirus 71 3C proteinase (strain E2004104-TW-CDC) and its complex with rupintrivir. |
Acta Crystallogr D Biol Crystallogr |
2013 |
Wu C;Cai Q;Chen C;Li N;Peng X;Cai Y;Yin K;Chen X;Wang X;Zhang R;Liu L;Chen S;Li J;Lin T |
View
More |
2429196
|
[Can anything curative be done against the common cold?]. |
Ned Tijdschr Geneeskd |
1986 |
de Jong JC |
View
More |
24366736
|
Multiple classes of antiviral agents exhibit in vitro activity against human rhinovirus type C. |
Antimicrob Agents Chemother |
2014 |
Mello C;Aguayo E;Rodriguez M;Lee G;Jordan R;Cihlar T;Birkus G |
View
More |
25261311
|
Proteases of human rhinovirus: role in infection. |
Methods Mol Biol |
2015 |
Jensen LM;Walker EJ;Jans DA;Ghildyal R |
View
More |
2542566
|
Genetic and molecular analyses of spontaneous mutants of human rhinovirus 14 that are resistant to an antiviral compound. |
J Virol |
1989 |
Heinz BA;Rueckert RR;Shepard DA;Dutko FJ;McKinlay MA;Fancher M;Rossmann MG;Badger J;Smith TJ |
View
More |
2558631
|
Drug resistant rhinoviruses from the nose of experimentally treated volunteers. |
Arch Virol |
1989 |
Dearden C;al-Nakib W;Andries K;Woestenborghs R;Tyrrell DA |
View
More |
2559655
|
In vitro and in vivo activities of WIN 54954, a new broad-spectrum antipicornavirus drug. |
Antimicrob Agents Chemother |
1989 |
Woods MG;Diana GD;Rogge MC;Otto MJ;Dutko FJ;McKinlay MA |
View
More |
25792507
|
Peptidomimetic ethyl propenoate covalent inhibitors of the enterovirus 71 3C protease: a P2-P4 study. |
J Enzyme Inhib Med Chem |
2016 |
Ang MJ;Lau QY;Ng FM;Then SW;Poulsen A;Cheong YK;Ngoh ZX;Tan YW;Peng J;Keller TH;Hill J;Chu JJ;Chia CS |
View
More |
26055377
|
The enterovirus 3C protease inhibitor SG85 efficiently blocks rhinovirus replication and is not cross-resistant with rupintrivir. |
Antimicrob Agents Chemother |
2015 |
Lacroix C;George S;Leyssen P;Hilgenfeld R;Neyts J |
View
More |
2831362
|
Enantiomeric effects of homologues of disoxaril on the inhibitory activity against human rhinovirus-14. |
J Med Chem |
1988 |
Diana GD;Otto MJ;Treasurywala AM;McKinlay MA;Oglesby RC;Maliski EG;Rossmann MG;Smith TJ |
View
More |
2913305
|
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus. |
J Med Chem |
1989 |
Diana GD;Cutcliffe D;Oglesby RC;Otto MJ;Mallamo JP;Akullian V;McKinlay MA |
View
More |
29530860
|
Selection and Characterization of Rupintrivir-Resistant Norwalk Virus Replicon Cells In Vitro. |
Antimicrob Agents Chemother |
2018 |
Kitano M;Hosmillo M;Emmott E;Lu J;Goodfellow I |
View
More |
2989517
|
Isoxazoles with antipicornavirus activity. |
J Med Chem |
1985 |
Diana GD;McKinlay MA;Brisson CJ;Zalay ES;Miralles JV;Salvador UJ |
View
More |
2992365
|
In vitro activity of WIN 51711, a new broad-spectrum antipicornavirus drug. |
Antimicrob Agents Chemother |
1985 |
Otto MJ;Fox MP;Fancher MJ;Kuhrt MF;Diana GD;McKinlay MA |
View
More |
2999407
|
[[(4,5-Dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles. Inhibitors of picornavirus uncoating. |
J Med Chem |
1985 |
Diana GD;McKinlay MA;Otto MJ;Akullian V;Oglesby C |
View
More |
3014575
|
Inhibitors of picornavirus uncoating as antiviral agents. |
Pharmacol Ther |
1985 |
Diana GD;Otto MJ;McKinlay MA |
View
More |
3018924
|
The site of attachment in human rhinovirus 14 for antiviral agents that inhibit uncoating. |
Science |
1986 |
Smith TJ;Kremer MJ;Luo M;Vriend G;Arnold E;Kamer G;Rossmann MG;McKinlay MA;Diana GD;Otto MJ |
View
More |
3019232
|
Prevention of rhinovirus and poliovirus uncoating by WIN 51711, a new antiviral drug. |
Antimicrob Agents Chemother |
1986 |
Fox MP;Otto MJ;McKinlay MA |
View
More |
3027340
|
Structure-activity studies of 5-[[4-(4,5-dihydro-2-oxazolyl) phenoxy]alkyl]-3-methylisoxazoles: inhibitors of picornavirus uncoating. |
J Med Chem |
1987 |
Diana GD;Oglesby RC;Akullian V;Carabateas PM;Cutcliffe D;Mallamo JP;Otto MJ;McKinlay MA;Maliski EG;Michalec SJ |
View
More |
31640701
|
Rupintrivir reduces RV-induced TH-2 cytokine IL-4 in precision-cut lung slices (PCLS) of HDM-sensitized mice ex vivo. |
Respir Res |
2019 |
Danov O;Lasswitz L;Obernolte H;Hesse C;Braun A;Wronski S;Sewald K |
View
More |
32103448
|
Structure of the HRV-C 3C-Rupintrivir Complex Provides New Insights for Inhibitor Design. |
Virol Sin |
2020 |
Yuan S;Fan K;Chen Z;Sun Y;Hou H;Zhu L |
View
More |
34181859
|
Rhinovirus-induced Human Lung Tissue Responses Mimic Chronic Obstructive Pulmonary Disease and Asthma Gene Signatures. |
Am J Respir Cell Mol Biol |
2021 |
Wronski S;Beinke S;Obernolte H;Belyaev NN;Saunders KA;Lennon MG;Schaudien D;Braubach P;Jonigk D;Warnecke G;Zardo P;Fieguth HG;Wilkens L;Braun A;Hessel EM;Sewald K |
View
More |
34506130
|
Pan-3C Protease Inhibitor Rupintrivir Binds SARS-CoV-2 Main Protease in a Unique Binding Mode. |
Biochemistry |
2021 |
Lockbaum GJ;Henes M;Lee JM;Timm J;Nalivaika EA;Thompson PR;Kurt Yilmaz N;Schiffer CA |
View
More |
34960671
|
RIPK1 Is Cleaved by 3C Protease of Rhinovirus A and B Strains and Minor and Major Groups. |
Viruses |
2021 |
Croft SN;Walker EJ;Ghildyal R |
View
More |
7473717
|
Structural studies on human rhinovirus 14 drug-resistant compensation mutants. |
J Mol Biol |
1995 |
Hadfield AT;Oliveira MA;Kim KH;Minor I;Kremer MJ;Heinz BA;Shepard D;Pevear DC;Rueckert RR;Rossmann MG |
View
More |
7500332
|
A novel basis of capsid stabilization by antiviral compounds. |
J Mol Biol |
1995 |
Phelps DK;Post CB |
View
More |
7629816
|
[(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors. |
J Med Chem |
1995 |
Guiles JW;Diana GD;Pevear DC |
View
More |
7731021
|
Picornavirus inhibitors: trifluoromethyl substitution provides a global protective effect against hepatic metabolism. |
J Med Chem |
1995 |
Diana GD;Rudewicz P;Pevear DC;Nitz TJ;Aldous SC;Aldous DJ;Robinson DT;Draper T;Dutko FJ;Aldi C;et al. |
View
More |
7811059
|
Antiviral capsid-binding compounds can inhibit the adsorption of minor receptor rhinoviruses. |
Antiviral Res |
1994 |
Dewindt B;van Eemeren K;Andries K |
View
More |
7990117
|
An evaluation of the antirhinoviral activity of acetylfuran replacements for 3-methylisoxazoles. Are 2-acetylfurans bioisosteres for 3-methylisoxazoles? |
J Med Chem |
1994 |
Bailey TR;Diana GD;Mallamo JP;Vescio N;Draper TL;Carabateas PM;Long MA;Giranda VL;Dutko FJ;Pevear DC |
View
More |
8057290
|
Oxadiazoles as ester bioisosteric replacements in compounds related to disoxaril. Antirhinovirus activity. |
J Med Chem |
1994 |
Diana GD;Volkots DL;Nitz TJ;Bailey TR;Long MA;Vescio N;Aldous S;Pevear DC;Dutko FJ |
View
More |
8230114
|
Antipicornavirus activity of tetrazole analogues related to disoxaril. |
J Med Chem |
1993 |
Diana GD;Cutcliffe D;Volkots DL;Mallamo JP;Bailey TR;Vescio N;Oglesby RC;Nitz TJ;Wetzel J;Giranda V;et al. |
View
More |
8246217
|
On the mechanism of HRV-14 antiviral compounds: "slow growth" as a conformational search procedure. |
J Med Chem |
1993 |
Guha-Biswas M;Holder M;Pettitt BM |
View
More |
8383239
|
WIN 52035-2 inhibits both attachment and eclipse of human rhinovirus 14. |
J Virol |
1993 |
Shepard DA;Heinz BA;Rueckert RR |
View
More |
8383771
|
A comparison of the anti-rhinoviral drug binding pocket in HRV14 and HRV1A. |
J Mol Biol |
1993 |
Kim KH;Willingmann P;Gong ZX;Kremer MJ;Chapman MS;Minor I;Oliveira MA;Rossmann MG;Andries K;Diana GD;et al. |
View
More |
8383943
|
Efficacy of oral WIN 54954 for prophylaxis of experimental rhinovirus infection. |
Antimicrob Agents Chemother |
1993 |
Turner RB;Dutko FJ;Goldstein NH;Lockwood G;Hayden FG |
View
More |
8391247
|
SCH 38057: a picornavirus capsid-binding molecule with antiviral activity after the initial stage of viral uncoating. |
Antiviral Res |
1993 |
Rozhon E;Cox S;Buontempo P;O'Connell J;Slater W;De Martino J;Schwartz J;Miller G;Arnold E;Zhang A;et al. |
View
More |
8767845
|
Synthesis and antirhinovirus activity of 3-(diethylamino)-5-phenylisoxazole derivatives. |
Farmaco |
1996 |
Mazzei M;Garzoglio R;Balbi A;Grandi T;De Montis A;Corrias S;La Colla P |
View
More |
8939746
|
Human rhinovirus 3 at 3.0 A resolution. |
Structure |
1996 |
Zhao R;Pevear DC;Kremer MJ;Giranda VL;Kofron JA;Kuhn RJ;Rossmann MG |
View
More |
8940202
|
Rhinovirus inhibits antigen-specific T cell proliferation through an intercellular adhesion molecule-1-dependent mechanism. |
J Infect Dis |
1996 |
Gern JE;Joseph B;Galagan DM;Borcherding WR;Dick EC |
View
More |
9122218
|
The pentamer channel stiffening model for drug action on human rhinovirus HRV-1A. |
Proc Natl Acad Sci U S A |
1997 |
Vaidehi N;Goddard WA 3rd |
View
More |
9445020
|
WIN 52035-dependent human rhinovirus 16: assembly deficiency caused by mutations near the canyon surface. |
J Virol |
1998 |
Wang W;Lee WM;Mosser AG;Rueckert RR |
View
More |
9512706
|
Influence of an antiviral compound on the temperature dependence of viral protein flexibility and packing: a molecular dynamics study. |
J Mol Biol |
1998 |
Phelps DK;Rossky PJ;Post CB |
View
More |
9618488
|
Antiviral agent blocks breathing of the common cold virus. |
Proc Natl Acad Sci U S A |
1998 |
Lewis JK;Bothner B;Smith TJ;Siuzdak G |
View
More |