PMID Title Journal Publication Year Author View in RVdb
10197965 Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 4. Incorporation of P1 lactam moieties as L-glutamine replacements. J Med Chem 1999 Dragovich PS;Prins TJ;Zhou R;Webber SE;Marakovits JT;Fuhrman SA;Patick AK;Matthews DA;Lee CA;Ford CE;Burke BJ;Rejto PA;Hendrickson TF;Tuntland T;Brown EL;Meador JW 3rd;Ferre RA;Harr JE;Kosa MB;Worland ST View More
10500114 Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes. Proc Natl Acad Sci U S A 1999 Matthews DA;Dragovich PS;Webber SE;Fuhrman SA;Patick AK;Zalman LS;Hendrickson TF;Love RA;Prins TJ;Marakovits JT;Zhou R;Tikhe J;Ford CE;Meador JW;Ferre RA;Brown EL;Binford SL;Brothers MA;DeLisle DM;Worland ST View More
10508022 In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease. Antimicrob Agents Chemother 1999 Patick AK;Binford SL;Brothers MA;Jackson RL;Ford CE;Diem MD;Maldonado F;Dragovich PS;Zhou R;Prins TJ;Fuhrman SA;Meador JW;Zalman LS;Matthews DA;Worland ST View More
10595531 Molecular dynamics investigation of the effect of an antiviral compound on human rhinovirus. Protein Sci 1999 Phelps DK;Post CB View More
10611281 Analysis of three structurally related antiviral compounds in complex with human rhinovirus 16. Proc Natl Acad Sci U S A 1999 Hadfield AT;Diana GD;Rossmann MG View More
10770757 Inhibition of human rhinovirus-induced cytokine production by AG7088, a human rhinovirus 3C protease inhibitor. Antimicrob Agents Chemother 2000 Zalman LS;Brothers MA;Dragovich PS;Zhou R;Prins TJ;Worland ST;Patick AK View More
10782382 Disoxaril-related 3-(diethylamino)-5-phenylisoxazoles. Farmaco 2000 Mazzei M;Dondero R;Ledda B;Demontis F;Vargiu L View More
10974374 In vitro activity of pleconaril and AG7088 against selected serotypes and clinical isolates of human rhinoviruses. Antiviral Res 2000 Kaiser L;Crump CE;Hayden FG View More
11159387 Molecular dynamics simulations of human rhinovirus and an antiviral compound. Biophys J 2001 Speelman B;Brooks BR;Post CB View More
11166856 The treatment of rhinovirus infections: progress and potential. Antiviral Res 2001 Turner RB View More
11249711 AG-7088 Pfizer. Curr Opin Investig Drugs 2000 Witherell G View More
11302940 Liquid chromatography-mass spectrometry and liquid chromatography-NMR characterization of in vitro metabolites of a potent and irreversible peptidomimetic inhibitor of rhinovirus 3C protease. Drug Metab Dispos 2001 Zhang KE;Hee B;Lee CA;Liang B;Potts BC View More
11796347 Pharmacokinetics and safety of an antirhinoviral agent, ruprintrivir, in healthy volunteers. Antimicrob Agents Chemother 2002 Hsyu PH;Pithavala YK;Gersten M;Penning CA;Kerr BM View More
11920874 Kinetics of thermal denaturation of human rhinoviruses in the presence of anti-viral capsid binders analyzed by capillary electrophoresis. Electrophoresis 2002 Okun VM;Nizet S;Blaas D;Kenndler E View More
12413027 Motion of an antiviral compound in a rhinovirus capsid under rotational symmetry boundary conditions. J Mol Graph Model 2002 Yoneda S;Yoneda T;Kurihara Y;Umeyama H View More
12515488 Virus-ligand interactions: identification and characterization of ligand binding by NMR spectroscopy. J Am Chem Soc 2003 Benie AJ;Moser R;Bauml E;Blaas D;Peters T View More
12743280 Human rhinovirus type 16: mutant V1210A requires capsid-binding drug for assembly of pentamers to form virions during morphogenesis. J Virol 2003 Lee WM;Wang W View More
12746549 Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs. Science 2003 Anand K;Ziebuhr J;Wadhwani P;Mesters JR;Hilgenfeld R View More
1313108 CoMFA analysis of the interactions of antipicornavirus compounds in the binding pocket of human rhinovirus-14. J Med Chem 1992 Diana GD;Kowalczyk P;Treasurywala AM;Oglesby RC;Pevear DC;Dutko FJ View More
1335079 Antirhinoviral activity of heterocyclic analogs of Win 54954. J Med Chem 1992 Bailey TR;Diana GD;Kowalczyk PJ;Akullian V;Eissenstat MA;Cutcliffe D;Mallamo JP;Carabateas PM;Pevear DC View More
1335081 Conformationally restricted analogues of disoxaril: a comparison of the activity against human rhinovirus types 14 and 1A. J Med Chem 1992 Mallamo JP;Diana GD;Pevear DC;Dutko FJ;Chapman MS;Kim KH;Minor I;Oliveira M;Rossmann MG View More
14517058 Human rhinovirus capsid dynamics is controlled by canyon flexibility. Virology 2003 Reisdorph N;Thomas JJ;Katpally U;Chase E;Harris K;Siuzdak G;Smith TJ View More
14638501 Phase II, randomized, double-blind, placebo-controlled studies of ruprintrivir nasal spray 2-percent suspension for prevention and treatment of experimentally induced rhinovirus colds in healthy volunteers. Antimicrob Agents Chemother 2003 Hayden FG;Turner RB;Gwaltney JM;Chi-Burris K;Gersten M;Hsyu P;Patick AK;Smith GJ 3rd;Zalman LS View More
15673742 Conservation of amino acids in human rhinovirus 3C protease correlates with broad-spectrum antiviral activity of rupintrivir, a novel human rhinovirus 3C protease inhibitor. Antimicrob Agents Chemother 2005 Binford SL;Maldonado F;Brothers MA;Weady PT;Zalman LS;Meador JW 3rd;Matthews DA;Patick AK View More
15743897 Novel [(biphenyloxy)propyl]isoxazole derivatives for inhibition of human rhinovirus 2 and coxsackievirus B3 replication. J Antimicrob Chemother 2005 Makarov VA;Riabova OB;Granik VG;Wutzler P;Schmidtke M View More
15899980 Dissociation of an antiviral compound from the internal pocket of human rhinovirus 14 capsid. Proc Natl Acad Sci U S A 2005 Li Y;Zhou Z;Post CB View More
15944313 The role of p38 MAPK in rhinovirus-induced monocyte chemoattractant protein-1 production by monocytic-lineage cells. J Immunol 2005 Hall DJ;Bates ME;Guar L;Cronan M;Korpi N;Bertics PJ View More
16387393 Physico-chemical characterization of disoxaril-dimethyl-beta-cyclodextrin inclusion complex and in vitro permeation studies. Eur J Med Chem 2006 Ventura CA;Giannone I;Musumeci T;Pignatello R;Ragni L;Landolfi C;Milanese C;Paolino D;Puglisi G View More
1656851 Binding affinities of structurally related human rhinovirus capsid-binding compounds are related to their activities against human rhinovirus type 14. Antimicrob Agents Chemother 1991 Fox MP;McKinlay MA;Diana GD;Dutko FJ View More
1666824 A comparative test of fifteen compounds against all known human rhinovirus serotypes as a basis for a more rational screening program. Antiviral Res 1991 Andries K;Dewindt B;Snoeks J;Willebrords R;Stokbroekx R;Lewi PJ View More
17161425 VP4 protein from human rhinovirus 14 is released by pressure and locked in the capsid by the antiviral compound WIN. J Mol Biol 2007 Goncalves RB;Mendes YS;Soares MR;Katpally U;Smith TJ;Silva JL;Oliveira AC View More
17428846 Pocket factors are unlikely to play a major role in the life cycle of human rhinovirus. J Virol 2007 Katpally U;Smith TJ View More
17485072 Development of potent inhibitors of the coxsackievirus 3C protease. Biochem Biophys Res Commun 2007 Lee ES;Lee WG;Yun SH;Rho SH;Im I;Yang ST;Sellamuthu S;Lee YJ;Kwon SJ;Park OK;Jeon ES;Park WJ;Kim YC View More
17665898 Quantitative structure-activity relationship studies of [(biphenyloxy)propyl]isoxazole derivatives. Inhibitors of human rhinovirus 2 replication. J Med Chem 2007 Kuz'min VE;Artemenko AG;Muratov EN;Volineckaya IL;Makarov VA;Riabova OB;Wutzler P;Schmidtke M View More
17908951 In vitro resistance study of rupintrivir, a novel inhibitor of human rhinovirus 3C protease. Antimicrob Agents Chemother 2007 Binford SL;Weady PT;Maldonado F;Brothers MA;Matthews DA;Patick AK View More
1847178 Stabilization of human rhinovirus serotype 2 against pH-induced conformational change by antiviral compounds. J Gen Virol 1991 Gruenberger M;Pevear D;Diana GD;Kuechler E;Blaas D View More
18840470 New pleconaril and [(biphenyloxy)propyl]isoxazole derivatives with substitutions in the central ring exhibit antiviral activity against pleconaril-resistant coxsackievirus B3. Antiviral Res 2009 Schmidtke M;Wutzler P;Zieger R;Riabova OB;Makarov VA View More
20066739 Rupintrivir is a promising candidate for treating severe cases of Enterovirus-71 infection. World J Gastroenterol 2010 Zhang XN;Song ZG;Jiang T;Shi BS;Hu YW;Yuan ZH View More
2158559 A model for compounds active against human rhinovirus-14 based on X-ray crystallography data. J Med Chem 1990 Diana GD;Treasurywala AM;Bailey TR;Oglesby RC;Pevear DC;Dutko FJ View More
21795339 Enterovirus 71 and coxsackievirus A16 3C proteases: binding to rupintrivir and their substrates and anti-hand, foot, and mouth disease virus drug design. J Virol 2011 Lu G;Qi J;Chen Z;Xu X;Gao F;Lin D;Qian W;Liu H;Jiang H;Yan J;Gao GF View More
21813612 Crystal structures of enterovirus 71 3C protease complexed with rupintrivir reveal the roles of catalytically important residues. J Virol 2011 Wang J;Fan T;Yao X;Wu Z;Guo L;Lei X;Wang J;Wang M;Jin Q;Cui S View More
21835784 Structural basis for antiviral inhibition of the main protease, 3C, from human enterovirus 93. J Virol 2011 Costenaro L;Kaczmarska Z;Arnan C;Janowski R;Coutard B;Sola M;Gorbalenya AE;Norder H;Canard B;Coll M View More
23295352 Rupintrivir is a promising candidate for treating severe cases of enterovirus-71 infection: evaluation of antiviral efficacy in a murine infection model. Antiviral Res 2013 Zhang X;Song Z;Qin B;Zhang X;Chen L;Hu Y;Yuan Z View More
23549610 The newly emerged SARS-like coronavirus HCoV-EMC also has an "Achilles\' heel": current effective inhibitor targeting a 3C-like protease. Protein Cell 2013 Ren Z;Yan L;Zhang N;Guo Y;Yang C;Lou Z;Rao Z View More
23633597 Structures of Enterovirus 71 3C proteinase (strain E2004104-TW-CDC) and its complex with rupintrivir. Acta Crystallogr D Biol Crystallogr 2013 Wu C;Cai Q;Chen C;Li N;Peng X;Cai Y;Yin K;Chen X;Wang X;Zhang R;Liu L;Chen S;Li J;Lin T View More
2429196 [Can anything curative be done against the common cold?]. Ned Tijdschr Geneeskd 1986 de Jong JC View More
24366736 Multiple classes of antiviral agents exhibit in vitro activity against human rhinovirus type C. Antimicrob Agents Chemother 2014 Mello C;Aguayo E;Rodriguez M;Lee G;Jordan R;Cihlar T;Birkus G View More
25261311 Proteases of human rhinovirus: role in infection. Methods Mol Biol 2015 Jensen LM;Walker EJ;Jans DA;Ghildyal R View More
2542566 Genetic and molecular analyses of spontaneous mutants of human rhinovirus 14 that are resistant to an antiviral compound. J Virol 1989 Heinz BA;Rueckert RR;Shepard DA;Dutko FJ;McKinlay MA;Fancher M;Rossmann MG;Badger J;Smith TJ View More
2558631 Drug resistant rhinoviruses from the nose of experimentally treated volunteers. Arch Virol 1989 Dearden C;al-Nakib W;Andries K;Woestenborghs R;Tyrrell DA View More
2559655 In vitro and in vivo activities of WIN 54954, a new broad-spectrum antipicornavirus drug. Antimicrob Agents Chemother 1989 Woods MG;Diana GD;Rogge MC;Otto MJ;Dutko FJ;McKinlay MA View More
25792507 Peptidomimetic ethyl propenoate covalent inhibitors of the enterovirus 71 3C protease: a P2-P4 study. J Enzyme Inhib Med Chem 2016 Ang MJ;Lau QY;Ng FM;Then SW;Poulsen A;Cheong YK;Ngoh ZX;Tan YW;Peng J;Keller TH;Hill J;Chu JJ;Chia CS View More
26055377 The enterovirus 3C protease inhibitor SG85 efficiently blocks rhinovirus replication and is not cross-resistant with rupintrivir. Antimicrob Agents Chemother 2015 Lacroix C;George S;Leyssen P;Hilgenfeld R;Neyts J View More
2831362 Enantiomeric effects of homologues of disoxaril on the inhibitory activity against human rhinovirus-14. J Med Chem 1988 Diana GD;Otto MJ;Treasurywala AM;McKinlay MA;Oglesby RC;Maliski EG;Rossmann MG;Smith TJ View More
2913305 Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus. J Med Chem 1989 Diana GD;Cutcliffe D;Oglesby RC;Otto MJ;Mallamo JP;Akullian V;McKinlay MA View More
29530860 Selection and Characterization of Rupintrivir-Resistant Norwalk Virus Replicon Cells In Vitro. Antimicrob Agents Chemother 2018 Kitano M;Hosmillo M;Emmott E;Lu J;Goodfellow I View More
2989517 Isoxazoles with antipicornavirus activity. J Med Chem 1985 Diana GD;McKinlay MA;Brisson CJ;Zalay ES;Miralles JV;Salvador UJ View More
2992365 In vitro activity of WIN 51711, a new broad-spectrum antipicornavirus drug. Antimicrob Agents Chemother 1985 Otto MJ;Fox MP;Fancher MJ;Kuhrt MF;Diana GD;McKinlay MA View More
2999407 [[(4,5-Dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles. Inhibitors of picornavirus uncoating. J Med Chem 1985 Diana GD;McKinlay MA;Otto MJ;Akullian V;Oglesby C View More
3014575 Inhibitors of picornavirus uncoating as antiviral agents. Pharmacol Ther 1985 Diana GD;Otto MJ;McKinlay MA View More
3018924 The site of attachment in human rhinovirus 14 for antiviral agents that inhibit uncoating. Science 1986 Smith TJ;Kremer MJ;Luo M;Vriend G;Arnold E;Kamer G;Rossmann MG;McKinlay MA;Diana GD;Otto MJ View More
3019232 Prevention of rhinovirus and poliovirus uncoating by WIN 51711, a new antiviral drug. Antimicrob Agents Chemother 1986 Fox MP;Otto MJ;McKinlay MA View More
3027340 Structure-activity studies of 5-[[4-(4,5-dihydro-2-oxazolyl) phenoxy]alkyl]-3-methylisoxazoles: inhibitors of picornavirus uncoating. J Med Chem 1987 Diana GD;Oglesby RC;Akullian V;Carabateas PM;Cutcliffe D;Mallamo JP;Otto MJ;McKinlay MA;Maliski EG;Michalec SJ View More
31640701 Rupintrivir reduces RV-induced TH-2 cytokine IL-4 in precision-cut lung slices (PCLS) of HDM-sensitized mice ex vivo. Respir Res 2019 Danov O;Lasswitz L;Obernolte H;Hesse C;Braun A;Wronski S;Sewald K View More
32103448 Structure of the HRV-C 3C-Rupintrivir Complex Provides New Insights for Inhibitor Design. Virol Sin 2020 Yuan S;Fan K;Chen Z;Sun Y;Hou H;Zhu L View More
34181859 Rhinovirus-induced Human Lung Tissue Responses Mimic Chronic Obstructive Pulmonary Disease and Asthma Gene Signatures. Am J Respir Cell Mol Biol 2021 Wronski S;Beinke S;Obernolte H;Belyaev NN;Saunders KA;Lennon MG;Schaudien D;Braubach P;Jonigk D;Warnecke G;Zardo P;Fieguth HG;Wilkens L;Braun A;Hessel EM;Sewald K View More
34506130 Pan-3C Protease Inhibitor Rupintrivir Binds SARS-CoV-2 Main Protease in a Unique Binding Mode. Biochemistry 2021 Lockbaum GJ;Henes M;Lee JM;Timm J;Nalivaika EA;Thompson PR;Kurt Yilmaz N;Schiffer CA View More
34960671 RIPK1 Is Cleaved by 3C Protease of Rhinovirus A and B Strains and Minor and Major Groups. Viruses 2021 Croft SN;Walker EJ;Ghildyal R View More
7473717 Structural studies on human rhinovirus 14 drug-resistant compensation mutants. J Mol Biol 1995 Hadfield AT;Oliveira MA;Kim KH;Minor I;Kremer MJ;Heinz BA;Shepard D;Pevear DC;Rueckert RR;Rossmann MG View More
7500332 A novel basis of capsid stabilization by antiviral compounds. J Mol Biol 1995 Phelps DK;Post CB View More
7629816 [(Biaryloxy)alkyl]isoxazoles: picornavirus inhibitors. J Med Chem 1995 Guiles JW;Diana GD;Pevear DC View More
7731021 Picornavirus inhibitors: trifluoromethyl substitution provides a global protective effect against hepatic metabolism. J Med Chem 1995 Diana GD;Rudewicz P;Pevear DC;Nitz TJ;Aldous SC;Aldous DJ;Robinson DT;Draper T;Dutko FJ;Aldi C;et al. View More
7811059 Antiviral capsid-binding compounds can inhibit the adsorption of minor receptor rhinoviruses. Antiviral Res 1994 Dewindt B;van Eemeren K;Andries K View More
7990117 An evaluation of the antirhinoviral activity of acetylfuran replacements for 3-methylisoxazoles. Are 2-acetylfurans bioisosteres for 3-methylisoxazoles? J Med Chem 1994 Bailey TR;Diana GD;Mallamo JP;Vescio N;Draper TL;Carabateas PM;Long MA;Giranda VL;Dutko FJ;Pevear DC View More
8057290 Oxadiazoles as ester bioisosteric replacements in compounds related to disoxaril. Antirhinovirus activity. J Med Chem 1994 Diana GD;Volkots DL;Nitz TJ;Bailey TR;Long MA;Vescio N;Aldous S;Pevear DC;Dutko FJ View More
8230114 Antipicornavirus activity of tetrazole analogues related to disoxaril. J Med Chem 1993 Diana GD;Cutcliffe D;Volkots DL;Mallamo JP;Bailey TR;Vescio N;Oglesby RC;Nitz TJ;Wetzel J;Giranda V;et al. View More
8246217 On the mechanism of HRV-14 antiviral compounds: "slow growth" as a conformational search procedure. J Med Chem 1993 Guha-Biswas M;Holder M;Pettitt BM View More
8383239 WIN 52035-2 inhibits both attachment and eclipse of human rhinovirus 14. J Virol 1993 Shepard DA;Heinz BA;Rueckert RR View More
8383771 A comparison of the anti-rhinoviral drug binding pocket in HRV14 and HRV1A. J Mol Biol 1993 Kim KH;Willingmann P;Gong ZX;Kremer MJ;Chapman MS;Minor I;Oliveira MA;Rossmann MG;Andries K;Diana GD;et al. View More
8383943 Efficacy of oral WIN 54954 for prophylaxis of experimental rhinovirus infection. Antimicrob Agents Chemother 1993 Turner RB;Dutko FJ;Goldstein NH;Lockwood G;Hayden FG View More
8391247 SCH 38057: a picornavirus capsid-binding molecule with antiviral activity after the initial stage of viral uncoating. Antiviral Res 1993 Rozhon E;Cox S;Buontempo P;O'Connell J;Slater W;De Martino J;Schwartz J;Miller G;Arnold E;Zhang A;et al. View More
8767845 Synthesis and antirhinovirus activity of 3-(diethylamino)-5-phenylisoxazole derivatives. Farmaco 1996 Mazzei M;Garzoglio R;Balbi A;Grandi T;De Montis A;Corrias S;La Colla P View More
8939746 Human rhinovirus 3 at 3.0 A resolution. Structure 1996 Zhao R;Pevear DC;Kremer MJ;Giranda VL;Kofron JA;Kuhn RJ;Rossmann MG View More
8940202 Rhinovirus inhibits antigen-specific T cell proliferation through an intercellular adhesion molecule-1-dependent mechanism. J Infect Dis 1996 Gern JE;Joseph B;Galagan DM;Borcherding WR;Dick EC View More
9122218 The pentamer channel stiffening model for drug action on human rhinovirus HRV-1A. Proc Natl Acad Sci U S A 1997 Vaidehi N;Goddard WA 3rd View More
9445020 WIN 52035-dependent human rhinovirus 16: assembly deficiency caused by mutations near the canyon surface. J Virol 1998 Wang W;Lee WM;Mosser AG;Rueckert RR View More
9512706 Influence of an antiviral compound on the temperature dependence of viral protein flexibility and packing: a molecular dynamics study. J Mol Biol 1998 Phelps DK;Rossky PJ;Post CB View More
9618488 Antiviral agent blocks breathing of the common cold virus. Proc Natl Acad Sci U S A 1998 Lewis JK;Bothner B;Smith TJ;Siuzdak G View More