| Title | Isoxazoles with antipicornavirus activity. | ||
| Author | Diana, G D; McKinlay, M A; Brisson, C J; Zalay, E S; Miralles, J V; Salvador, U J | ||
| Journal | J Med Chem | Publication Year/Month | 1985-Jun |
| PMID | 2989517 | PMCID | -N/A- |
The synthesis and evaluation of a series of 3,5-disubstituted isoxazoles as antipicornavirus agents have led to the discovery of several compounds effective in vitro against rhinovirus type 2 and poliovirus type 2. Compound 32 was found more effective than 4\',6-dichloroflavan against both viruses and was evaluated orally in mice infected intracerebrally with polio-2. At 31 mg/kg bid, compound 32 showed a 53% survival rate as compared to 22% for the nonmedicated animals.