PMID Title Journal Publication Year Author View in RVdb
10224078 Identification and characterization of human rhinovirus-14 3C protease deamidation isoform. J Biol Chem 1999 Cox GA;Johnson RB;Cook JA;Wakulchik M;Johnson MG;Villarreal EC;Wang QM View More
10794684 Substituted benzamide inhibitors of human rhinovirus 3C protease: structure-based design, synthesis, and biological evaluation. J Med Chem 2000 Reich SH;Johnson T;Wallace MB;Kephart SE;Fuhrman SA;Worland ST;Matthews DA;Hendrickson TF;Chan F;Meador J 3rd;Ferre RA;Brown EL;DeLisle DM;Patick AK;Binford SL;Ford CE View More
10813815 Conservation of polar residues as hot spots at protein interfaces. Proteins 2000 Hu Z;Ma B;Wolfson H;Nussinov R View More
10867028 2A proteinase of human rhinovirus cleaves cytokeratin 8 in infected HeLa cells. J Biol Chem 2000 Seipelt J;Liebig HD;Sommergruber W;Gerner C;Kuechler E View More
10950388 Antiviral therapy for enteroviruses and rhinoviruses. Antivir Chem Chemother 2000 Rotbart HA View More
11118371 Complete nucleotide sequence of the chiba virus genome and functional expression of the 3C-like protease in Escherichia coli. Virology 2000 Someya Y;Takeda N;Miyamura T View More
11162821 Activation of human rhinovirus-14 3C protease. Virology 2001 Wang QM;Johnson RB View More
11911365 Determinants of the recognition of enteroviral cloverleaf RNA by coxsackievirus B3 proteinase 3C. RNA 2002 Zell R;Sidigi K;Bucci E;Stelzner A;Gorlach M View More
12370021 Inhibition of cysteine protease activity by NO-donors. Curr Protein Pept Sci 2001 Ascenzi P;Salvati L;Bolognesi M;Colasanti M;Polticelli F;Venturini G View More
15080921 Exploring the binding mechanism of the main proteinase in SARS-associated coronavirus and its implication to anti-SARS drug design. Bioorg Med Chem 2004 Zhang XW;Yap YL View More
1658106 Rhinovirus 3C protease catalyzes efficient cleavage of a fluorescein-labeled peptide affording a rapid and robust assay. J Biochem Biophys Methods 1991 Hopkins JL;Betageri R;Cohen KA;Emmanuel MJ;Joseph CR;Bax PM;Pallai PV;Skoog MT View More
16759084 Isatin compounds as noncovalent SARS coronavirus 3C-like protease inhibitors. J Med Chem 2006 Zhou L;Liu Y;Zhang W;Wei P;Huang C;Pei J;Yuan Y;Lai L View More
17007846 Defining residues involved in human rhinovirus 2A proteinase substrate recognition. FEBS Lett 2006 Sousa C;Schmid EM;Skern T View More
17305557 Human rhinovirus 3C protease as a potential target for the development of antiviral agents. Curr Protein Pept Sci 2007 Wanga QM;Chen SH View More
18583140 Design, synthesis, and evaluation of 3C protease inhibitors as anti-enterovirus 71 agents. Bioorg Med Chem 2008 Kuo CJ;Shie JJ;Fang JM;Yen GR;Hsu JT;Liu HG;Tseng SN;Chang SC;Lee CY;Shih SR;Liang PH View More
19268541 A picornaviral loop-to-loop replication complex. J Struct Biol 2009 Claridge JK;Headey SJ;Chow JY;Schwalbe M;Edwards PJ;Jeffries CM;Venugopal H;Trewhella J;Pascal SM View More
21543871 Crystallization and preliminary diffraction analysis of the CAL PDZ domain in complex with a selective peptide inhibitor. Acta Crystallogr Sect F Struct Biol Cryst Commun 2011 Amacher JF;Cushing PR;Weiner JA;Madden DR View More
21664926 Homology modeling, docking, molecular dynamics simulation, and structural analyses of coxsakievirus B3 2A protease: an enzyme involved in the pathogenesis of inflammatory myocarditis. Int J Biol Macromol 2011 Maghsoudi AH;Khodagholi F;Hadi-Alijanvand H;Esfandiarei M;Sabbaghian M;Zakeri Z;Shaerzadeh F;Abtahi S;Maghsoudi N View More
23388726 3C protease of enterovirus 68: structure-based design of Michael acceptor inhibitors and their broad-spectrum antiviral effects against picornaviruses. J Virol 2013 Tan J;George S;Kusov Y;Perbandt M;Anemuller S;Mesters JR;Norder H;Coutard B;Lacroix C;Leyssen P;Neyts J;Hilgenfeld R View More
24125888 Design, synthesis, and bioevaluation of viral 3C and 3C-like protease inhibitors. Bioorg Med Chem Lett 2013 Prior AM;Kim Y;Weerasekara S;Moroze M;Alliston KR;Uy RA;Groutas WC;Chang KO;Hua DH View More
25350699 Novel prodrug-like fusion toxin with protease-sensitive bioorthogonal PEGylation for tumor targeting. Bioconjug Chem 2014 Stefan N;Zimmermann M;Simon M;Zangemeister-Wittke U;Pluckthun A View More
25792507 Peptidomimetic ethyl propenoate covalent inhibitors of the enterovirus 71 3C protease: a P2-P4 study. J Enzyme Inhib Med Chem 2016 Ang MJ;Lau QY;Ng FM;Then SW;Poulsen A;Cheong YK;Ngoh ZX;Tan YW;Peng J;Keller TH;Hill J;Chu JJ;Chia CS View More
28217559 A Novel Enterovirus 71 (EV71) Virulence Determinant: The 69th Residue of 3C Protease Modulates Pathogenicity. Front Cell Infect Microbiol 2017 Li B;Yue Y;Zhang Y;Yuan Z;Li P;Song N;Lin W;Liu Y;Gu L;Meng H View More
28801725 Optimization of Soluble Expression and Purification of Recombinant Human Rhinovirus Type-14 3C Protease Using Statistically Designed Experiments: Isolation and Characterization of the Enzyme. Mol Biotechnol 2017 Antoniou G;Papakyriacou I;Papaneophytou C View More
30118570 Building and Breaking Bonds via a Compact S-Propargyl-Cysteine to Chemically Control Enzymes and Modify Proteins. Angew Chem Int Ed Engl 2018 Liu J;Cheng R;Wu H;Li S;Wang PG;DeGrado WF;Rozovsky S;Wang L View More
31117169 Design of a Human Rhinovirus-14 3C Protease-Inducible Caspase-3. Molecules 2019 Wagner HJ;Weber W View More
32619644 Covalent and non-covalent strategies for the immobilization of Tobacco Etch Virus protease (TEVp) on superparamagnetic nanoparticles. J Biotechnol 2020 Norris JL;Patel T;Dasari AKR;Cope TA;Lim KH;Hughes RM View More
34230602 A split protease-E. coli ClpXP system quantifies protein-protein interactions in Escherichia coli cells. Commun Biol 2021 Wang S;Zhang F;Mei M;Wang T;Yun Y;Yang S;Zhang G;Yi L View More
34626801 Expression and purification of a cleavable recombinant fortilin from Escherichia coli for structure activity studies. Protein Expr Purif 2022 Cantrell MS;Wall JD;Pu X;Turner M;Woodbury L;Fujise K;McDougal OM;Warner LR View More
7794931 Peptide aldehyde inhibitors of hepatitis A virus 3C proteinase. Biochemistry 1995 Malcolm BA;Lowe C;Shechosky S;McKay RT;Yang CC;Shah VJ;Simon RJ;Vederas JC;Santi DV View More
8761474 Human rhinovirus 2A proteinase mutant and its second-site revertants. Biochem J 1996 Luderer-Gmach M;Liebig HD;Sommergruber W;Voss T;Fessl F;Skern T;Kuechler E View More
8978838 Design, synthesis, and evaluation of nonpeptidic inhibitors of human rhinovirus 3C protease. J Med Chem 1996 Webber SE;Tikhe J;Worland ST;Fuhrman SA;Hendrickson TF;Matthews DA;Love RA;Patick AK;Meador JW;Ferre RA;Brown EL;DeLisle DM;Ford CE;Binford SL View More
9445078 Enzymatic characterization of refolded human rhinovirus type 14 2A protease expressed in Escherichia coli. J Virol 1998 Wang QM;Johnson RB;Cox GA;Villarreal EC;Churgay LM;Hale JE View More
9667969 Tripeptide aldehyde inhibitors of human rhinovirus 3C protease: design, synthesis, biological evaluation, and cocrystal structure solution of P1 glutamine isosteric replacements. J Med Chem 1998 Webber SE;Okano K;Little TL;Reich SH;Xin Y;Fuhrman SA;Matthews DA;Love RA;Hendrickson TF;Patick AK;Meador JW 3rd;Ferre RA;Brown EL;Ford CE;Binford SL;Worland ST View More
9667970 Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 1. Michael acceptor structure-activity studies. J Med Chem 1998 Dragovich PS;Webber SE;Babine RE;Fuhrman SA;Patick AK;Matthews DA;Lee CA;Reich SH;Prins TJ;Marakovits JT;Littlefield ES;Zhou R;Tikhe J;Ford CE;Wallace MB;Meador JW 3rd;Ferre RA;Brown EL;Binford SL;Harr JE;DeLisle DM;Worland ST View More
9667971 Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 2. Peptide structure-activity studies. J Med Chem 1998 Dragovich PS;Webber SE;Babine RE;Fuhrman SA;Patick AK;Matthews DA;Reich SH;Marakovits JT;Prins TJ;Zhou R;Tikhe J;Littlefield ES;Bleckman TM;Wallace MB;Little TL;Ford CE;Meador JW 3rd;Ferre RA;Brown EL;Binford SL;DeLisle DM;Worland ST View More
9681985 Development of in vitro peptide substrates for human rhinovirus-14 2A protease. Arch Biochem Biophys 1998 Wang QM;Johnson RB;Sommergruber W;Shepherd TA View More