Title Identification of a novel human rhinovirus C type by antibody capture VIDISCA-454.
Author Jazaeri Farsani, Seyed Mohammad; Oude Munnink, Bas B; Canuti, Marta; Deijs, Martin; Cotten, Matthew; Jebbink, Maarten F; Verhoeven, Joost; Kellam, Paul; Loens, Katherine; Goossens, Herman; Ieven, Margareta; van der Hoek, Lia
Journal Viruses Publication Year/Month 2015-Jan
PMID 25606972 PMCID PMC4306836
Affiliation + expend 1.Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center of the University of Amsterdam, Amsterdam 1105 AZ, the Netherlands. s.m.jazaerifarsani@amc.uva.nl.

Causative agents for more than 30 percent of respiratory infections remain unidentified, suggesting that unknown respiratory pathogens might be involved. In this study, antibody capture VIDISCA-454 (virus discovery cDNA-AFLP combined with Roche 454 high-throughput sequencing) resulted in the discovery of a novel type of rhinovirus C (RV-C). The virus has an RNA genome of at least 7054 nt and carries the characteristics of rhinovirus C species. The gene encoding viral protein 1, which is used for typing, has only 81% nucleotide sequence identity with the closest known RV-C type, and, therefore, the virus represents the first member of a novel type, named RV-C54.

StrainID RV Species Serotype Length(nt) Country Year Strain Name
CNC03834 C 54 7054 Spain 2009 D3490
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