Title | Autonomic Function Tests in Prehypertensive Young Adult Males of Uttarakhand Region. | ||
Author | Moinuddin, Arsalan; Gupta, Rani; Saxena, Yogesh | ||
Journal | Indian J Physiol Pharmacol | Publication Year/Month | 2016-Jan-Mar |
PMID | 29953193 | PMCID | -N/A- |
Pre-hypertensives are at increased risk for rise in blood pressure and cardio vascular morbidities. Autonomic dysfunction is both a cause and effect of high blood pressure. Considering its serious prognosis the current study was undertaken with an aim to assess autonomic functions in pre-hypertensive young adult males. Male volunteers of 20-40 years were divided into normotensives (n=44) and clinically healthy pre-hypertensives (n=44). They were subjected to anthropometric measurements, Heart Rate variability (HRV) analysis along with Standard Isometric Handgrip Test (HGT) and Sinus arrhythmia test. Analysis showed a significant increase in sympathetic activity among prehypertensives characterized by lower rise in DBP (mmHg) in response to HGT: [11.27+/-3.76 mmHg vs 23.95+/-6.29 mmHg, (p<0.05)]. Parasympathetic activity was significantly decreased among prehypertensives (HFnu: 30.02+/-14.43 vs 41.62+/-14.91, p<0.05); E/I ratio: 1.20+/-0.10 vs 1.32+/-0.10, p<0.05). Sympathovagal balance showed prominent sympathetic activity (2.85+/-1.78 vs 1.75+/-0.98; (p<0.01) among prehypertensives. Salt intake among prehypertensives was significantly higher than normotensives (21.2+/-1.2 gm/day vs 9.0+/-0.5 gm/day: P<0.001). Conclusion: Autonomic dysfunction is evident in prehypertensives with an enhanced sympathetic activity, decreased parasympathetic activity and an altered sympathovagal balance in prehypertensives, salt intake was found on a higher side. Thus lifestyle changes in the form of balanced diet and moderate exercise may be advised to attenuate the risk progression of prehypertension to hypertension.