| Title | Labdane-type diterpenoids from Vitex limonifolia and their antivirus activities. | ||
| Author | Ban, Ninh Khac; Thoa, Nguyen Thi Kim; Linh, Tran My; Trang, Do Thi; Van Kiem, Phan; Nhiem, Nguyen Xuan; Tai, Bui Huu; Van Minh, Chau; Song, Jae-Hyoung; Ko, Hyun-Jeong; Kim, Seung Hyun | ||
| Journal | J Nat Med | Publication Year/Month | 2018-Jan |
| PMID | 28914420 | PMCID | -N/A- |
| Affiliation + expend | 1.Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam. | ||
Phytochemical investigation of the methanol extract of Vitex limonifolia leaves led to the isolation of three new labdane-type diterpenoids, vitexlimolides A-C (1-3) and eight known compounds, 5,4\'-dihydroxy-3,7-dimethoxyflavone (4), vitecetin (5), 5,4\'-dihydroxy-7,3\'-dimethoxyflavone (6), verrucosin (7), 2alpha, 3alpha-dihydroxy-urs-12-en-28-oic acid (8), euscaphlic acid (9), 18,19-seco, 2alpha, 3alpha-dihydroxy-19-oxo-urs-11,13(18)-dien-28-oic acid (10), and maslinic acid (11). Their chemical structures were elucidated by physical and chemical methods. All compounds were evaluated for antiviral activities against CVB3, HRV1B, and EV71 viruses. As a result, compounds 4 and 6 showed potent antiviral activity against CVB3 infection with IC50 values of 0.12 +/- 0.06 and 1.86 +/- 0.18 (microM), respectively.