| Title | A theoretical study of the acidification of the rhinovirus capsid. | ||
| Author | Warwicker, J | ||
| Journal | FEBS Lett | Publication Year/Month | 1989-Nov |
| PMID | 2555222 | PMCID | -N/A- |
| Affiliation | 1.Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511. | ||
Electrostatic calculations for human rhinovirus 14 indicate that histidine-base residue pairs in the region of a beta-strand interaction between pentamers may be involved in a pH-induced process that leads to the release of viral RNA. Other picornavirus sequences are examined for these residue pairs, a subset of which is present in enteroviruses. Foot and mouth disease virus possesses one of the residue pairs, and cardioviruses, which undergo a separate pH and halide ion-induced capsid dissociation, possess none.