| Title | Application of crystallography to the design of antiviral agents. | ||
| Author | Rossmann, M G; McKinlay, M A | ||
| Journal | Infect Agents Dis | Publication Year/Month | 1992-Feb |
| PMID | 1365526 | PMCID | -N/A- |
| Affiliation | 1.Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907. | ||
A historical review of x-ray crystallography introduces basic concepts and describes the potential of this science to the rational design of antiviral agents. Following a brief introduction to the study of antiviral compounds that inhibit early stages of rhino- and enteroviral infections, the impact of structural studies on rational drug design is discussed in relation to known viral structures.