PMID Title Journal Publication Year Author View in RVdb
10197965 Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 4. Incorporation of P1 lactam moieties as L-glutamine replacements. J Med Chem 1999 Dragovich PS;Prins TJ;Zhou R;Webber SE;Marakovits JT;Fuhrman SA;Patick AK;Matthews DA;Lee CA;Ford CE;Burke BJ;Rejto PA;Hendrickson TF;Tuntland T;Brown EL;Meador JW 3rd;Ferre RA;Harr JE;Kosa MB;Worland ST View More
10500114 Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes. Proc Natl Acad Sci U S A 1999 Matthews DA;Dragovich PS;Webber SE;Fuhrman SA;Patick AK;Zalman LS;Hendrickson TF;Love RA;Prins TJ;Marakovits JT;Zhou R;Tikhe J;Ford CE;Meador JW;Ferre RA;Brown EL;Binford SL;Brothers MA;DeLisle DM;Worland ST View More
10508022 In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease. Antimicrob Agents Chemother 1999 Patick AK;Binford SL;Brothers MA;Jackson RL;Ford CE;Diem MD;Maldonado F;Dragovich PS;Zhou R;Prins TJ;Fuhrman SA;Meador JW;Zalman LS;Matthews DA;Worland ST View More
10770757 Inhibition of human rhinovirus-induced cytokine production by AG7088, a human rhinovirus 3C protease inhibitor. Antimicrob Agents Chemother 2000 Zalman LS;Brothers MA;Dragovich PS;Zhou R;Prins TJ;Worland ST;Patick AK View More
10974374 In vitro activity of pleconaril and AG7088 against selected serotypes and clinical isolates of human rhinoviruses. Antiviral Res 2000 Kaiser L;Crump CE;Hayden FG View More
11166856 The treatment of rhinovirus infections: progress and potential. Antiviral Res 2001 Turner RB View More
11249711 AG-7088 Pfizer. Curr Opin Investig Drugs 2000 Witherell G View More
11302940 Liquid chromatography-mass spectrometry and liquid chromatography-NMR characterization of in vitro metabolites of a potent and irreversible peptidomimetic inhibitor of rhinovirus 3C protease. Drug Metab Dispos 2001 Zhang KE;Hee B;Lee CA;Liang B;Potts BC View More
11796347 Pharmacokinetics and safety of an antirhinoviral agent, ruprintrivir, in healthy volunteers. Antimicrob Agents Chemother 2002 Hsyu PH;Pithavala YK;Gersten M;Penning CA;Kerr BM View More
12746549 Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs. Science 2003 Anand K;Ziebuhr J;Wadhwani P;Mesters JR;Hilgenfeld R View More
12791690 Human rhinovirus 2 2Apro recognition of eukaryotic initiation factor 4GI. Involvement of an exosite. J Biol Chem 2003 Foeger N;Schmid EM;Skern T View More
14638501 Phase II, randomized, double-blind, placebo-controlled studies of ruprintrivir nasal spray 2-percent suspension for prevention and treatment of experimentally induced rhinovirus colds in healthy volunteers. Antimicrob Agents Chemother 2003 Hayden FG;Turner RB;Gwaltney JM;Chi-Burris K;Gersten M;Hsyu P;Patick AK;Smith GJ 3rd;Zalman LS View More
15673742 Conservation of amino acids in human rhinovirus 3C protease correlates with broad-spectrum antiviral activity of rupintrivir, a novel human rhinovirus 3C protease inhibitor. Antimicrob Agents Chemother 2005 Binford SL;Maldonado F;Brothers MA;Weady PT;Zalman LS;Meador JW 3rd;Matthews DA;Patick AK View More
17485072 Development of potent inhibitors of the coxsackievirus 3C protease. Biochem Biophys Res Commun 2007 Lee ES;Lee WG;Yun SH;Rho SH;Im I;Yang ST;Sellamuthu S;Lee YJ;Kwon SJ;Park OK;Jeon ES;Park WJ;Kim YC View More
17908951 In vitro resistance study of rupintrivir, a novel inhibitor of human rhinovirus 3C protease. Antimicrob Agents Chemother 2007 Binford SL;Weady PT;Maldonado F;Brothers MA;Matthews DA;Patick AK View More
19272312 The autonomic phenotype of rumination. Int J Psychophysiol 2009 Ottaviani C;Shapiro D;Davydov DM;Goldstein IB;Mills PJ View More
19602137 Chronic hepatitis C virus infection associated with autonomic dysfunction. Liver Int 2009 Osztovits J;Horvath T;Abonyi M;Toth T;Visnyei Z;Beko G;Csak T;Lakatos PL;Littvay L;Feher J;Kempler P;Kollai M;Szalay F View More
20066739 Rupintrivir is a promising candidate for treating severe cases of Enterovirus-71 infection. World J Gastroenterol 2010 Zhang XN;Song ZG;Jiang T;Shi BS;Hu YW;Yuan ZH View More
21795339 Enterovirus 71 and coxsackievirus A16 3C proteases: binding to rupintrivir and their substrates and anti-hand, foot, and mouth disease virus drug design. J Virol 2011 Lu G;Qi J;Chen Z;Xu X;Gao F;Lin D;Qian W;Liu H;Jiang H;Yan J;Gao GF View More
21813612 Crystal structures of enterovirus 71 3C protease complexed with rupintrivir reveal the roles of catalytically important residues. J Virol 2011 Wang J;Fan T;Yao X;Wu Z;Guo L;Lei X;Wang J;Wang M;Jin Q;Cui S View More
21835784 Structural basis for antiviral inhibition of the main protease, 3C, from human enterovirus 93. J Virol 2011 Costenaro L;Kaczmarska Z;Arnan C;Janowski R;Coutard B;Sola M;Gorbalenya AE;Norder H;Canard B;Coll M View More
22381150 Spontaneous reports of primarily suspected herbal hepatotoxicity by Pelargonium sidoides: was causality adequately ascertained? Regul Toxicol Pharmacol 2012 Teschke R;Frenzel C;Schulze J;Eickhoff A View More
23295352 Rupintrivir is a promising candidate for treating severe cases of enterovirus-71 infection: evaluation of antiviral efficacy in a murine infection model. Antiviral Res 2013 Zhang X;Song Z;Qin B;Zhang X;Chen L;Hu Y;Yuan Z View More
23549610 The newly emerged SARS-like coronavirus HCoV-EMC also has an "Achilles\' heel": current effective inhibitor targeting a 3C-like protease. Protein Cell 2013 Ren Z;Yan L;Zhang N;Guo Y;Yang C;Lou Z;Rao Z View More
23633597 Structures of Enterovirus 71 3C proteinase (strain E2004104-TW-CDC) and its complex with rupintrivir. Acta Crystallogr D Biol Crystallogr 2013 Wu C;Cai Q;Chen C;Li N;Peng X;Cai Y;Yin K;Chen X;Wang X;Zhang R;Liu L;Chen S;Li J;Lin T View More
24366736 Multiple classes of antiviral agents exhibit in vitro activity against human rhinovirus type C. Antimicrob Agents Chemother 2014 Mello C;Aguayo E;Rodriguez M;Lee G;Jordan R;Cihlar T;Birkus G View More
2460866 Identification of an immunodominant antigenic site involving the capsid protein VP3 of hepatitis A virus. Proc Natl Acad Sci U S A 1988 Ping LH;Jansen RW;Stapleton JT;Cohen JI;Lemon SM View More
25261311 Proteases of human rhinovirus: role in infection. Methods Mol Biol 2015 Jensen LM;Walker EJ;Jans DA;Ghildyal R View More
25792507 Peptidomimetic ethyl propenoate covalent inhibitors of the enterovirus 71 3C protease: a P2-P4 study. J Enzyme Inhib Med Chem 2016 Ang MJ;Lau QY;Ng FM;Then SW;Poulsen A;Cheong YK;Ngoh ZX;Tan YW;Peng J;Keller TH;Hill J;Chu JJ;Chia CS View More
26055377 The enterovirus 3C protease inhibitor SG85 efficiently blocks rhinovirus replication and is not cross-resistant with rupintrivir. Antimicrob Agents Chemother 2015 Lacroix C;George S;Leyssen P;Hilgenfeld R;Neyts J View More
26308831 Brazilian Jiu-Jitsu Simulated Competition Part I: Metabolic, Hormonal, Cellular Damage, and Heart Rate Responses. J Strength Cond Res 2015 Andreato LV;Julio UF;Panissa VL;Esteves JV;Hardt F;de Moraes SM;de Souza CO;Franchini E View More
26477783 Differential neutrophil activation in viral infections: Enhanced TLR-7/8-mediated CXCL8 release in asthma. Respirology 2016 Tang FS;Van Ly D;Spann K;Reading PC;Burgess JK;Hartl D;Baines KJ;Oliver BG View More
29437806 Rhabdomyolysis in Stuve-Wiedemann syndrome. BMJ Case Rep 2018 Ramdeny PS;Powell C;Chakraborty M;Hartley L View More
29530860 Selection and Characterization of Rupintrivir-Resistant Norwalk Virus Replicon Cells In Vitro. Antimicrob Agents Chemother 2018 Kitano M;Hosmillo M;Emmott E;Lu J;Goodfellow I View More
30974127 Advances in respiratory virus therapeutics - A meeting report from the 6th isirv Antiviral Group conference. Antiviral Res 2019 Beigel JH;Nam HH;Adams PL;Krafft A;Ince WL;El-Kamary SS;Sims AC View More
31640701 Rupintrivir reduces RV-induced TH-2 cytokine IL-4 in precision-cut lung slices (PCLS) of HDM-sensitized mice ex vivo. Respir Res 2019 Danov O;Lasswitz L;Obernolte H;Hesse C;Braun A;Wronski S;Sewald K View More
32103448 Structure of the HRV-C 3C-Rupintrivir Complex Provides New Insights for Inhibitor Design. Virol Sin 2020 Yuan S;Fan K;Chen Z;Sun Y;Hou H;Zhu L View More
33276032 Fetal cardiac dysfunction in intrahepatic cholestasis of pregnancy is associated with elevated serum bile acid concentrations. J Hepatol 2021 Vasavan T;Deepak S;Jayawardane IA;Lucchini M;Martin C;Geenes V;Yang J;Lovgren-Sandblom A;Seed PT;Chambers J;Stone S;Kurlak L;Dixon PH;Marschall HU;Gorelik J;Chappell L;Loughna P;Thornton J;Pipkin FB;Hayes-Gill B;Fifer WP;Williamson C View More
33444702 Inhibition of coronavirus infection by a synthetic STING agonist in primary human airway system. Antiviral Res 2021 Zhu Q;Zhang Y;Wang L;Yao X;Wu D;Cheng J;Pan X;Liu H;Yan Z;Gao L View More
34181859 Rhinovirus-induced Human Lung Tissue Responses Mimic Chronic Obstructive Pulmonary Disease and Asthma Gene Signatures. Am J Respir Cell Mol Biol 2021 Wronski S;Beinke S;Obernolte H;Belyaev NN;Saunders KA;Lennon MG;Schaudien D;Braubach P;Jonigk D;Warnecke G;Zardo P;Fieguth HG;Wilkens L;Braun A;Hessel EM;Sewald K View More
34506130 Pan-3C Protease Inhibitor Rupintrivir Binds SARS-CoV-2 Main Protease in a Unique Binding Mode. Biochemistry 2021 Lockbaum GJ;Henes M;Lee JM;Timm J;Nalivaika EA;Thompson PR;Kurt Yilmaz N;Schiffer CA View More
34873882 A Multicenter Study of Real-world Practice for Management of Abnormal Liver Function Tests in Children with Acute Infectious Diseases. J Korean Med Sci 2021 Lee Y;Yi DY;Lee YM;Choi SY;Choi YJ;Lee KJ View More
34960671 RIPK1 Is Cleaved by 3C Protease of Rhinovirus A and B Strains and Minor and Major Groups. Viruses 2021 Croft SN;Walker EJ;Ghildyal R View More
36073800 The Combined Escherichia coli Nissle 1917 and Tryptophan Treatment Modulates Immune and Metabolome Responses to Human Rotavirus Infection in a Human Infant Fecal Microbiota-Transplanted Malnourished Gnotobiotic Pig Model. mSphere 2022 Michael H;Srivastava V;Deblais L;Amimo JO;Chepngeno J;Saif LJ;Rajashekara G;Vlasova AN View More
36823196 Expanded profiling of Remdesivir as a broad-spectrum antiviral and low potential for interaction with other medications in vitro. Sci Rep 2023 Radoshitzky SR;Iversen P;Lu X;Zou J;Kaptein SJF;Stuthman KS;Van Tongeren SA;Steffens J;Gong R;Truong H;Sapre AA;Yang H;Xie X;Chia JJ;Song ZJ;Leventhal SM;Chan J;Shornikov A;Zhang X;Cowfer D;Yu H;Warren T;Cihlar T;Porter DP;Neyts J;Shi PY;Wells J;Bilello JP;Feng JY View More
3794904 Serum transaminase elevations in infants with rotavirus gastroenteritis. J Pediatr Gastroenterol Nutr 1986 Kovacs A;Chan L;Hotrakitya C;Overturf G;Portnoy B View More
4106351 Late stage synchronization of respiratory syncytial virus replication. Virology 1971 Levine S;Buthala DA;Hamilton RD View More
4370230 Nucleoside peptides. 6. Synthesis of certain N-(5-amino-1-(beta-D-ribofuranosyl)imidazole-4-carbonyl)amino acids related to naturally occurring intermediates in the purine biosynthetic pathway. J Med Chem 1974 Srivastava PC;Mancuso RW;Rousseau RJ;Robins RK View More
9079380 Structure-based design of peptide presentation on a viral surface: the crystal structure of a plant/animal virus chimera at 2.8 A resolution. Fold Des 1996 Lin T;Porta C;Lomonossoff G;Johnson JE View More
9269752 Tat-human immunodeficiency virus-1 induces human monocyte chemotaxis by activation of vascular endothelial growth factor receptor-1. Blood 1997 Mitola S;Sozzani S;Luini W;Primo L;Borsatti A;Weich H;Bussolino F View More