| Title | Modelling of the tertiary structure of coxsackievirus B3 from the structure of poliovirus and rhinovirus. | ||
| Author | Liljas, L; Lindberg, A M; Pettersson, U | ||
| Journal | Scand J Infect Dis Suppl | Publication Year/Month | 1993 |
| PMID | 8390718 | PMCID | -N/A- |
| Affiliation | 1.Dept. of Molecular Biology and Medical Genetics, Uppsala University, Sweden. | ||
The amino acid sequence of the coat proteins of coxsackievirus B3(CB3) was aligned to the sequence of poliovirus and rhinovirus. A model of the tertiary structure of CB3 was built from the known structure of poliovirus 1 and rhinovirus type 14. The CB3 protein shell is predicted to be similar to that of poliovirus and rhinovirus. The model shows that the surface loops which constitute the major immunogenic sites in these viruses are highly exposed also in CB3. Also other features, as the canyon and the "WIN pocket" are also predicted to be conserved in CB3.