| Title | [Screening test of crude drug extract on anti-HIV activity]. | ||
| Author | Yamasaki, K; Otake, T; Mori, H; Morimoto, M; Ueba, N; Kurokawa, Y; Shiota, K; Yuge, T | ||
| Journal | Yakugaku Zasshi | Publication Year/Month | 1993-Nov |
| PMID | 8277430 | PMCID | -N/A- |
| Affiliation | 1.Osaka Prefectural Institute of Public Health, Japan. | ||
The anti-HIV-1 effects of 204 crude drugs of common use in Japan were evaluated in vitro. As a result, 45 samples inhibited HIV-1-induced cytopathogenicity in MT-4 cells. In particular, the hot water extracts of Lithospermum erythrorhizon (root) and Prunella vulgaris (spike) showed the strongest anti-HIV-1 activities. Their IC100 values were both 16 micrograms/ml. In general, the hot water extracts of the crude drug suppressed the replication of HIV-1 growth more strongly than the cold water extracts.