| Title | The nucleotide sequence of the 5\'non-coding and capsid coding genome regions of two bovine enterovirus strains. | ||
| Author | McNally, R M; Earle, J A; McIlhatton, M; Hoey, E M; Martin, S J | ||
| Journal | Arch Virol | Publication Year/Month | 1994 |
| PMID | 7832636 | PMCID | -N/A- |
| Affiliation | 1.Division of Molecular Biology, School of Biology and Biochemistry, Queen's University of Belfast, Northern Ireland. | ||
The sequence of cDNA clones representing the 5\' non-coding regions (NCR) and capsid regions of two bovine enteroviruses (strains PS-87 and RM-2; serotype two viruses) have been determined and compared with that obtained from a serotype one strain (VG-5-27). All three strains showed a longer 5\' NCR compared to human enteroviruses and rhinoviruses due in part to a hundred residue insertion approximately at a hundred residues in from the 5\' end. However, another domain occurring at nucleotide 187-222 in poliovirus is absent in each bovine enterovirus. Comparisons of the predicted structural protein amino acid sequences indicate that PS-87 shares most sequence identity with RM-2 and then with VG-5-27 in that order. The VP1 protein of PS-87 and RM-2 are shorter than the equivalent VP1 of VG-5-27 due in part to a truncation at their C-terminii. VP3 is only slightly smaller than VP2 in each virus.