| Title | Anti-interferon antibody increases rhinovirus isolation rates from nasal wash specimens containing interferon-alpha 2. | ||
| Author | Hayden, F G; Gwaltney, J M Jr | ||
| Journal | Antiviral Res | Publication Year/Month | 1983-Mar |
| PMID | 6307140 | PMCID | -N/A- |
Isolation of rhinoviruses from nasal secretions may be delayed or prevented by exogenously applied interferon which is carried over into nasal wash specimens. In studies of interferon-alpha 2 treated volunteers with experimental rhinovirus infection, we determined that incorporation of antiinterferon antibody into collection broth significantly increased isolation rates (84% increase) and the proportion of monolayers positive for CPE (155% increase), as compared to plain collection broth.