| Title | Antiviral activity of hetarylhydrazones. | ||
| Author | Tonew, M; Tonew, E; Indulen, M K; Dzeguze, D R; Oehring, H; Schmidt, J | ||
| Journal | Acta Virol | Publication Year/Month | 1982-May |
| PMID | 6127013 | PMCID | -N/A- |
Some hetarylhydrazones showed antiviral activity against Mengo virus in vitro. The replication of influenza A and B viruses was affected neither in vitro (chick chorioallantoic membranes) nor in vivo (mice). Based on dose response curves of the active hetarylhydrazones the compound Z 98/69 appeared most effective in vitro. This compound neither inactivated the extracellular virus nor inhibited its adsorption and penetration; it reduced virus replication when added 1-3 hr after Mengo virus inoculation. As shown by plaque reduction test vaccinia virus was also inhibited. A partial inhibition of rhinovirus 1B multiplication was observed whereas other picornaviruses were not affected.