Title Comparison of common human respiratory pathogens among hospitalized children aged </= 6 years in Hainan Island, China, during spring and early summer in 2019-2021.
Author Mai, Wenhui; Ren, Yi; Tian, Xiuying; Al-Mahdi, Abdullah Y; Peng, Ruoyan; An, Jing; Lin, Qiuyu; Hu, Xiaoyuan; Wang, Gaoyu; Sun, Changjia; Lu, Zhe; Du, Jiang; Xiao, Meifang; Yin, Feifei
Journal J Med Virol Publication Year/Month 2023-Apr
PMID 36946502 PMCID -N/A-
Affiliation + expend 1.Haikou Maternal and Child Health Hospital, Haikou, Hainan, China.

The coronavirus disease 2019 (COVID-19) pandemic and related public health intervention measures have been reported to have resulted in the reduction of infections caused by influenza viruses and other common respiratory viruses. However, the influence may be varied in areas that have different ecological, economic, and social conditions. This study investigated the changing epidemiology of 8 common respiratory pathogens, including Influenza A (IFVA), Influenza B (IFVB), Respiratory syncytial virus (HRSV), rhinovirus (RV), Human metapneumovirus Adenovirus, Human bocavirus, and Mycoplasma pneumoniae, among hospitalized children during spring and early summer in 2019-2021 in two hospitals in Hainan Island, China, in the COVID-19 pandemic era. The results revealed a significant reduction in the prevalence of IFVA and IFVB in 2020 and 2021 than in 2019, whereas the prevalence of HRSV increased, and it became the dominant viral pathogen in 2021. RV was one of the leading pathogens in the 3 year period, where no significant difference was observed. Phylogenetic analysis revealed close relationships among the circulating respiratory viruses. Large scale studies are needed to study the changing epidemiology of seasonal respiratory viruses to inform responses to future respiratory virus pandemics.

StrainID RV Species Serotype Length(nt) Country Year Strain Name
UNS07183 Unclassified None 449 China 2019 RV-Hainan-HMU-HKU-R63-2019
UNS07184 Unclassified None 451 China 2021 RV-Hainan-HMU-HKU-0609056-2021
UNS07185 Unclassified None 449 China 2021 RV-Hainan-HMU-HKU-0609021-2021
UNS07186 Unclassified None 465 China 2021 RV-Hainan-HMU-HKU-0609037-2021
UNS07187 Unclassified None 438 China 2020 RV-Hainan-HMU-HKU-H2-2020
UNS07188 Unclassified None 438 China 2019 RV-Hainan-HMU-HKU-R47-2019
UNS07189 Unclassified None 419 China 2019 RV-Hainan-HMU-HKU-R13-2019
UNS07190 Unclassified None 447 China 2020 RV-Hainan-HMU-HKU-H8-2020
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