| Title | The clinical outcomes of COVID-19 critically ill patients co-infected with other respiratory viruses: a multicenter, cohort study. | ||
| Author | Al Sulaiman, Khalid; Aljuhani, Ohoud; Badreldin, Hisham A; Korayem, Ghazwa B; Alenazi, Abeer A; Alharbi, Ahlam H; Alghamdi, Albandari; Alhubaishi, Alaa; Altebainawi, Ali F; Bosaeed, Mohammad; Alotaibi, Rand; Alawad, Ahad; Alnajjar, Nirvana; Bin Saleh, Khalid; Sait, Walaa A; Alsohimi, Samiah; Alanizy, Meshari M; Almuqbil, Sarah A; Al Sulaihim, Ibrahim; Vishwakarma, Ramesh; Alalawi, Mai; Alhassan, Fatimah; Alghnam, Suliman | ||
| Journal | BMC Infect Dis | Publication Year/Month | 2023-Feb |
| PMID | 36747136 | PMCID | PMC9901824 |
| Affiliation + expend | 1.Pharmaceutical Care Department, King Abdulaziz Medical City (KAMC)-Ministry of National Guard Health Affairs (MNGHA), Riyadh, Saudi Arabia. alsulaimankh@hotmail.com. | ||
BACKGROUND: Previous studies have shown that non-critically ill COVID-19 patients co-infected with other respiratory viruses have poor clinical outcomes. However, limited studies focused on this co-infections in critically ill patients. This study aims to evaluate the clinical outcomes of critically ill patients infected with COVID-19 and co-infected by other respiratory viruses. METHODS: A multicenter retrospective cohort study was conducted for all adult patients with COVID-19 who were hospitalized in the ICUs between March, 2020 and July, 2021. Eligible patients were sub-categorized into two groups based on simultaneous co-infection with other respiratory viruses throughout their ICU stay. Influenza A or B, Human Adenovirus (AdV), Human Coronavirus (i.e., 229E, HKU1, NL63, or OC43), Human Metapneumovirus, Human Rhinovirus/Enterovirus, Middle East Respiratory Syndrome Coronavirus (MERS-CoV), Parainfluenza virus, and Respiratory Syncytial Virus (RSV) were among the respiratory viral infections screened. Patients were followed until discharge from the hospital or in-hospital death. RESULTS: A total of 836 patients were included in the final analysis. Eleven patients (1.3%) were infected concomitantly with other respiratory viruses. Rhinovirus/Enterovirus (38.5%) was the most commonly reported co-infection. No difference was observed between the two groups regarding the 30-day mortality (HR 0.39, 95% CI 0.13, 1.20; p = 0.10). The in-hospital mortality was significantly lower among co-infected patients with other respiratory viruses compared with patients who were infected with COVID-19 alone (HR 0.32 95% CI 0.10, 0.97; p = 0.04). Patients concomitantly infected with other respiratory viruses had longer median mechanical ventilation (MV) duration and hospital length of stay (LOS). CONCLUSION: Critically ill patients with COVID-19 who were concomitantly infected with other respiratory viruses had comparable 30-day mortality to those not concomitantly infected. Further proactive testing and care may be required in the case of co-infection with respiratory viruses and COVID-19. The results of our study need to be confirmed by larger studies.