The aim of this study was to analyze the psychophysiological response of a Crohn\'s Disease patient in an ultra-endurance event. The psychophysiological responses of a Crohn\'s Disease and non-Crohn\'s Disease participant were analysed before during and after an 8 h ultra-endurance running event. Results showed how Crohn\'s patient presented a similar psychophysiological response than non-Crohn\'s participant in the ultra-endurance event, except for a higher pre- and post-event sympathetic modulation, lower event sympathetic tone, and lower event body temperature. This study could contribute to improving physical activity recommendations for persons with Crohn\'s Disease and open a new research line for an improved understanding of psychophysiological modifications of Crohn\'s Disease patients during exercise.