Epilepsy is a chronic disease with a significant social impact, given that the patients and their families often live conditioned by the possibility of an epileptic seizure and its possible consequences, such as accidents, injuries, or even sudden unexplained death. In this context, ambulatory monitoring allows the collection of biomedical data about the patients\' health, thus gaining more knowledge about the physiological state and daily activities of each patient in a more personalized manner. For this reason, this article proposes a novel monitoring system composed of different sensors capable of synchronously recording electrocardiogram (ECG), photoplethysmogram (PPG), and ear electroencephalogram (EEG) signals and storing them for further processing and analysis in a microSD card. This system can be used in a static and/or ambulatory way, providing information about the health state through features extracted from the ear EEG signal and the calculation of the heart rate variability (HRV) and pulse travel time (PTT). The different applied processing techniques to improve the quality of these signals are described in this work. A novel algorithm used to compute HRV and PTT robustly and accurately in ambulatory settings is also described. The developed device has also been validated and compared with other commercial systems obtaining similar results. In this way, based on the quality of the obtained signals and the low variability of the computed parameters, even in ambulatory conditions, the developed device can potentially serve as a support tool for clinical decision-taking stages.