| Title | Frequency of respiratory pathogens other than SARS-CoV-2 detected during COVID-19 testing. | ||
| Author | Boschiero, Matheus Negri; Duarte, Aires; Palamim, Camila Vantini Capasso; Alvarez, Alfonso Eduardo; Mauch, Renan Marrichi; Marson, Fernando Augusto Lima | ||
| Journal | Diagn Microbiol Infect Dis | Publication Year/Month | 2022-Feb |
| PMID | 34800846 | PMCID | PMC8531239 |
| Affiliation + expend | 1.Laboratory of Cell and Molecular Tumor Biology and Bioactive Compounds, Universidade Sao Francisco, Braganca Paulista, Sao Paulo, Brazil; Laboratory of Human and Medical Genetics, Universidade Sao Francisco, Braganca Paulista, Sao Paulo, Brazil. | ||
The frequencies of 19 respiratory pathogens other than SARS-CoV-2 were assessed in 6,"?>235 Brazilian individuals tested for COVID-19. Overall, only 83 individuals who tested positive for SARS-CoV-2 had codetection of other pathogens. Individuals infected with Rhinovirus/Enterovirus, Human Coronavirus (HCoV)-HKU1, HCoV-NL63, HPIV-4, Influenza A (-H1N1 and other subtypes), Influenza B, Human Respiratory Syncytial Virus and Human Metapneumovirus were less likely to test positive for SARS-CoV-2. Infection with Streptococcys pyogenes, Chlamydophila pneumoniae, Mycoplasma pneumoniae, and Bordetella pertussis were more frequent in individuals who tested negative for SARS-CoV-2, but without significancy. We found 150 individuals infected with >/=2 pathogens other than SARS-CoV-2, only 3 out of whom tested positive for COVID-19. The codetection frequency was low in individuals diagnosed with COVID-19. Other viral infections may provide a cross-reactive, protective immune response against SARS-CoV-2. Screening for bacterial respiratory infections upon COVID-19 testing is important to drive suitable therapeutic approaches and avoid unnecessary antibiotic prescription.