| Title | Phenotypic comparison of human alveolar macrophages before and after in vivo rhinovirus 16 challenge. | ||
| Author | de Groot, Linsey E S; Brinkman, Paul; Sabogal Pineros, Yanaika S; Priller, Josef; Hamann, Jorg; Bottcher, Chotima; Lutter, Rene | ||
| Journal | Eur J Immunol | Publication Year/Month | 2021-Nov |
| PMID | 34492126 | PMCID | PMC9292529 |
| Affiliation + expend | 1.Department of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands. | ||
We used mass cytometry to extensively characterize bronchoalveolar lavage macrophages before and two days after in vivo rhinovirus 16 infection in a heterogeneous population of healthy and asthma/COPD subjects. Multivariate partial least squares discriminant analysis revealed distinct clusters of alveolar macrophages before versus after the virus, suggesting changes in overall phenotype.