| Title | Response of heart rate variability and cardiorespiratory phase synchronization to routine bronchodilator test in patients with asthma. | ||
| Author | Tsou, Chih-Hsiang; Pon, Lin-Sen; Liang, Jun-Zhi; Chan, Yun-Hsiang; Chen, Kuan-Jung; Cheng, Feng-Shiang; Kao, Tsair; Yang, Sai-Wei | ||
| Journal | Chin J Physiol | Publication Year/Month | 2021-Jul-Aug |
| PMID | 34472448 | PMCID | -N/A- |
| Affiliation + expend | 1.Division of Chest Medicine, Ren-Ai Branch, Taipei City Hospital, Taipei; Department of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taiwan. | ||
Heart rate variability (HRV) and cardiorespiratory phase synchronization (CRPS) were employed to study the cardio- and respiratory interactions in patients with asthma receiving inhalation of beta2-agonist (Berotec 200 mcg) for routine bronchodilator test. Both time- and frequency-domain parameters were used to analyze the HRV. A weighted G-index was introduced to study the quality of the CRPS. The HRV parameters, in both the time and frequency domains, exhibited significant changes pointing to a sympathetic activation of the autonomic balance immediately after the inhalation. On the other hand, the CRPS index barely changed throughout the entire process. This indicates that inhalation of beta2-agonist does not alter the CRPS appreciably, and that the CRPS, in contrast to HRV, is relatively stable in response to the inhalation of beta2-agonist in patients with asthma.