Title Objectifying the Subjective: The Use of Heart Rate Variability as a Psychosocial Symptom Biomarker in Hospice and Palliative Care Research.
Author Taylor, Mallory R; Scott, Samantha R; Steineck, Angela; Rosenberg, Abby R
Journal J Pain Symptom Manage Publication Year/Month 2021-Sep
PMID 33933615 PMCID PMC8418996
Affiliation + expend 1.University of Washington School of Medicine, Department of Pediatrics, Division of Hematology/Oncology, Seattle, Washington, USA; Palliative Care and Resilience Lab, Center for Clinical and Translational Research, Seattle Children's Research Institute, Seattle, Washington, USA. Electronic address: Molly.taylor@seattlechildrens.org.

Measuring psychosocial symptoms in hospice and palliative care research is critical to understanding the patient and caregiver experience. Subjective patient-reported outcome tools have been the primary method for collecting these data in palliative care, and the growing field of biobehavioral research offers new tools that could deepen our understanding of psychosocial symptomatology. Here we describe one psychosocial biomarker, heart rate variability (HRV), and simple techniques for measurement in an adolescent and young adult cancer population that are applicable to palliative care studies. Complementing self-reported measures with objective biomarkers like HRV could facilitate a more nuanced understanding of physiologic and perceived well-being in patients with serious or life-limiting illness and inform future "precision supportive care" in hospice and palliative medicine.

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