| Title | Intranasal chalcone, Ro 09-0410, as prophylaxis against rhinovirus infection in human volunteers. | ||
| Author | Al-Nakib, W; Higgins, P G; Barrow, I; Tyrrell, D A; Lenox-Smith, I; Ishitsuka, H | ||
| Journal | J Antimicrob Chemother | Publication Year/Month | 1987-Dec |
| PMID | 3326874 | PMCID | -N/A- |
| Affiliation | 1.MRC Common Cold Unit, Harvard Hospital, Salisbury, Wiltshire, U.K. | ||
The antirhinovirus agent chalcone Ro 09-0410 was tested in double-blind place-controlled volunteer trials for its protective efficacy against experimental rhinovirus infection. Fifty volunteers received either drug (26 volunteers) or placebo (24 volunteers) both before and after challenge with 20-40 tissue culture infecting dose (TCID50) of human rhinovirus 2 (RV2). There was no evidence that medication significantly reduced the incidence of infection or illness, indeed there was some increase in the nasal secretion produced.