| Title | Genome sequencing and phylogenetic reconstruction reveal a potential fourth rhinovirus species and its worldwide distribution. | ||
| Author | Ng, Kim Tien; Takebe, Yutaka; Kamarulzaman, Adeeba; Tee, Kok Keng | ||
| Journal | Arch Virol | Publication Year/Month | 2021-Jan |
| PMID | 33084935 | PMCID | -N/A- |
| Affiliation + expend | 1.Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. | ||
Genome sequences of members of a potential fourth rhinovirus (RV) species, provisionally denoted as rhinovirus A clade D, from patients with acute respiratory infection were determined. Bayesian coalescent analysis estimated that clade D emerged around the 1940s and diverged further around 2006-2007 into two distinctive sublineages (RV-A8-like and RV-A45-like) that harbored unique "clade-defining" substitutions. Similarity plots and bootscan mapping revealed a recombination breakpoint located in the 5\'-UTR region of members of the RV-A8-like sublineage. Phylogenetic reconstruction revealed the distribution of clade D viruses in the Asia Pacific region and in Europe, underlining its worldwide distribution.