Title | An Inhomogeneous Point-process Model for the Assessment of the Brain-to-Heart Functional Interplay: a Pilot Study. | ||
Author | Talebi, Alireza; Catrambone, Vincenzo; Barbieri, Riccardo; Valenza, Gaetano | ||
Journal | Annu Int Conf IEEE Eng Med Biol Soc | Publication Year/Month | 2020-Jul |
PMID | 33018050 | PMCID | -N/A- |
We propose a novel computational framework for the estimation of functional directional brain-to-heart interplay in an instantaneous fashion. The framework is based on inhomogeneous point-process models for human heartbeat dynamics and employs inverse-Gaussian probability density functions characterizing the timing of R-peak events. The instantaneous estimation of the functional directional coupling is based on the definition of point-process transfer entropy, which is here retrieved from heart rate variability (HRV) and Electroencephalography (EEG) power spectral series gathered from 12 healthy subjects undergoing significant sympathovagal changes induced by a cold-pressor test. Results suggest that EEG oscillations dynamically influence heartbeat dynamics with specific time delays in the 30-60s and 90-120s ranges, and through a functional activity over specific cortical regions.