| Title | Lessons for COVID-19 Immunity from Other Coronavirus Infections. | ||
| Author | Sariol, Alan; Perlman, Stanley | ||
| Journal | Immunity | Publication Year/Month | 2020-Aug |
| PMID | 32717182 | PMCID | PMC7359787 |
| Affiliation + expend | 1.Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA. | ||
A key goal to controlling coronavirus disease 2019 (COVID-19) is developing an effective vaccine. Development of a vaccine requires knowledge of what constitutes a protective immune response and also features that might be pathogenic. Protective and pathogenic aspects of the response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are not well understood, partly because the virus has infected humans for only 6 months. However, insight into coronavirus immunity can be informed by previous studies of immune responses to non-human coronaviruses, common cold coronaviruses, and SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV). Here, we review the literature describing these responses and discuss their relevance to the SARS-CoV-2 immune response.