PURPOSE: This study aimed to compare heart rate variability (HRV) parameters obtained through symbolic analysis (SA), between older adults with and without hyperuricemia. METHODS: This is a cross-sectional study including 202 community-dwelling old adults, which was clinically stratified as with or without hyperuricemia, according to the cutoff point of serum uric acid >/= 6鈥痬g/dL for women and >/= 7鈥痬g/dL for men. Successive RR intervals were recorded along 5鈥痬in and analyzed with SA method. 0鈥疺%, 1鈥疺% and 2鈥疺% patterns were quantified and compared between groups. Comparisons were carried out through parametric or nonparametric tests, according to the data distribution characteristics, evaluated by Kolmogorov-Smirnov test. The signi fi cance level was set as p鈥?/=鈥?.05 for all statistical procedures. RESULTS: The prevalence of hyperuricemia was 67.8 %, and the hyperuricemic older adults exhibited significant higher values for V0% and lower values for V2% parameters when compared to normouricemic older adults. CONCLUSION: These results suggesting a sympathovagal imbalance in hyperuricemic older adults, characterized by greater sympathetic predominance (0鈥疺%) and lower vagal modulation (2鈥疺%) at rest conditions.