Title Toward personalization of asthma treatment according to trigger factors.
Author Niespodziana, Katarzyna; Borochova, Kristina; Pazderova, Petra; Schlederer, Thomas; Astafyeva, Natalia; Baranovskaya, Tatiana; Barbouche, Mohamed-Ridha; Beltyukov, Evgeny; Berger, Angelika; Borzova, Elena; Bousquet, Jean; Bumbacea, Roxana S; Bychkovskaya, Snezhana; Caraballo, Luis; Chung, Kian Fan; Custovic, Adnan; Docena, Guillermo; Eiwegger, Thomas; Evsegneeva, Irina; Emelyanov, Alexander; Errhalt, Peter; Fassakhov, Rustem; Fayzullina, Rezeda; Fedenko, Elena; Fomina, Daria; Gao, Zhongshan; Giavina-Bianchi, Pedro; Gotua, Maia; Greber-Platzer, Susanne; Hedlin, Gunilla; Ilina, Natalia; Ispayeva, Zhanat; Idzko, Marco; Johnston, Sebastian L; Kalayci, Omer; Karaulov, Alexander; Karsonova, Antonina; Khaitov, Musa; Kovzel, Elena; Kowalski, Marek L; Kudlay, Dmitry; Levin, Michael; Makarova, Svetlana; Matricardi, Paolo Maria; Nadeau, Kari C; Namazova-Baranova, Leyla; Naumova, Olga; Nazarenko, Oleksandr; O'Byrne, Paul M; Osier, Faith; Pampura, Alexander N; Panaitescu, Carmen; Papadopoulos, Nikolaos G; Park, Hae-Sim; Pawankar, Ruby; Pohl, Wolfgang; Renz, Harald; Riabova, Ksenja; Sampath, Vanitha; Sekerel, Bulent E; Sibanda, Elopy; Siroux, Valerie; Sizyakina, Ludmila P; Sun, Jin-Lyu; Szepfalusi, Zsolt; Umanets, Tetiana; Van Bever, Hugo P S; van Hage, Marianne; Vasileva, Margarita; von Mutius, Erika; Wang, Jiu-Yao; Wong, Gary W K; Zaikov, Sergii; Zidarn, Mihaela; Valenta, Rudolf
Journal J Allergy Clin Immunol Publication Year/Month 2020-Jun
PMID 32081759 PMCID PMC7613502
Affiliation + expend 1.Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.

Asthma is a severe and chronic disabling disease affecting more than 300 million people worldwide. Although in the past few drugs for the treatment of asthma were available, new treatment options are currently emerging, which appear to be highly effective in certain subgroups of patients. Accordingly, there is a need for biomarkers that allow selection of patients for refined and personalized treatment strategies. Recently, serological chip tests based on microarrayed allergen molecules and peptides derived from the most common rhinovirus strains have been developed, which may discriminate 2 of the most common forms of asthma, that is, allergen- and virus-triggered asthma. In this perspective, we argue that classification of patients with asthma according to these common trigger factors may open new possibilities for personalized management of asthma.

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