| Title | Rhinovirus and Asthma Exacerbations. | ||
| Author | Kennedy, Joshua L; Pham, Sarah; Borish, Larry | ||
| Journal | Immunol Allergy Clin North Am | Publication Year/Month | 2019-Aug |
| PMID | 31284924 | PMCID | PMC6625523 |
| Affiliation + expend | 1.Department of Pediatrics, University of Arkansas for Medical Sciences, 13 Children's Way, Slot 512-13, Little Rock, AR 72202, USA; Department of Internal Medicine, University of Arkansas for Medical Sciences, 13 Children's Way, Slot 512-13, Little Rock, AR 72202, USA; Arkansas Children's Research Institute, University of Arkansas for Medical Sciences, 13 Children's Way, Slot 512-13, Little Rock, AR 72202, USA. Electronic address: kennedyjoshual@uams.edu. | ||
Rhinovirus (RV) is ubiquitous and typically causes only minor upper respiratory symptoms. However, especially in children and adolescent asthmatics, RV is responsible for most exacerbations. This ability of RV to drive exacerbations typically requires the concomitant presence of exposure to a bystander allergen. Susceptibility to RV-mediated exacerbations is also related to the genetic background of the host, which contributes to greater infectivity, more severe infections, altered immune responses, and to greater inflammation and loss of asthma control. Given these responses, there are several treatments available or being developed that should improve the control of exacerbations related to RV infection.