The purpose of observation is to increase the effectiveness of treatment of children with chronic adenoiditis and exudative medium otitis. MATERIAL AND METHODS: In the observation were included 102 children with exudative medium otitis and chronic adenoiditis at the age of 3 to 14 years. All patients passed clinical and anamnestic diagnostic, endoscopic study, study of the nasopharynx, and PCR diagnostics of the stroke of the mucous membrane of the nasopharynx. The treatment was conducted, taking into account the patient\'s age, in the design of a simple randomized follow-up. RESULTS: In a nasopharynx children with chronic adenoiditis and exudative medium otitis revealed a predominance of viral and bacterial associations; among viruses, rhinovirus and adenovirus occupy a leading place. Effective complex conservative treatment was developed with the use of the Lysobact, which helps to reduce the frequency of prescribing antibacterial therapy. The use of lysozyme is one of the promising areas of treatment of chronic adenoiditis and exudative medium otitis.