| Title | Impact of RSV Coinfection on Human Bocavirus in Children with Acute Respiratory Infections. | ||
| Author | Sun, Huiming; Sun, Jiyang; Ji, Wei; Hao, Chuangli; Yan, Yongdong; Chen, Zhengrong; Wang, Yuqing | ||
| Journal | J Trop Pediatr | Publication Year/Month | 2019-Aug |
| PMID | 30202992 | PMCID | PMC7107312 |
| Affiliation + expend | 1.Attending, Department of Respiratory Medicine, Children's Hospital of Soochow University, Suzhou, Jiangsu, China. | ||
OBJECTIVE: The objective of this study was to assess epidemiological and clinical features of human bocavirus (HBoV) coinfection with other viruses. METHOD: Children coinfected with HBoV between January 2012 and December 2014 were enrolled and retrospectively reviewed. RESULT: A total of 984 patients were stratified into five groups: HBoV infection alone (n = 249), respiratory syncytial virus (RSV) infection alone (n = 649), HBoV coinfection with RSV (n = 28), with human rhinovirus (HRV) (n = 39) and with other virus (n = 19). Length of hospitalization was longer in HBoV coinfection with RSV group than HBoV (9.0 days vs. 7.0 days, p = 0.001), RSV (9.0 days vs. 8.0 days, p = 0.016) infection alone group. Pneumonia was more common in the HBoV coinfection with RSV group compared with the HBoV, RSV infection alone group, respectively (75.0% vs. 44.2%, 31.3%, p < 0.001). HBoV DNA copy numbers (383 000 copies/ml) were positively correlated with the length of hospitalization (r = 0.334, p < 0.001). CONCLUSION: HBoV coinfection with RSV increases HBoV infection severity.