Title | [The Impact of Effective Therapy With Atorvastatin on the Dynamics of Parameters of Electrical Instability in Patients with ST-Elevation Myocardial Infarction]. | ||
Author | Oleynikov, V E; Dushina, E V; Barmenkova, Y A; Lukyanova, M V; Salyamova, L I | ||
Journal | Kardiologiia | Publication Year/Month | 2018-Aug |
PMID | 30131038 | PMCID | -N/A- |
Affiliation | 1.Federal State Budgetary Educational Institution of Higher Education, "Penza State University". |
AIM: To assess the dynamics of parameters of myocardial electrical instability in patients with ST-elevation (STE) myocardial infarction (MI) treated with various doses of atorvastatin. MATERIALS AND METHODS: Patients with STEMI (n=70), who received atorvastatin 20 or 80 mg/day for 48 weeks, were divided into two groups: group "capital IE, Cyrillic" - 38 patients (54.3 %) in whom by 48鈥憈h week target values of low density lipoprotein cholesterol (LDLC) were achieved, and group "NE" - 32 patients (45.7 %) in whom these levels were not achieved. On days 7-9, at 24th and 48th weeks after onset of MI the patients underwent 24鈥慼our 12鈥憀eads ECG monitoring with subsequent analysis of parameters of myocardial electrical inhomogeneity: late ventricular potentials (LVP), dispersion of QT-interval duration, heart rate variability (HRV) and turbulence. RESULTS: After of treatment with atorvastatin target value of LDLC was achieved in 73.5 and 36.1 % of patients receiving 80 and 20 mg/day, respectively. In the group "E" we observed positive dynamics of LVP parameters (QRSf - p.