| Title | Antipicornavirus activity of substituted phenoxybenzenes and phenoxypyridines. | ||
| Author | Markley, L D; Tong, Y C; Dulworth, J K; Steward, D L; Goralski, C T; Johnston, H; Wood, S G; Vinogradoff, A P; Bargar, T M | ||
| Journal | J Med Chem | Publication Year/Month | 1986-Mar |
| PMID | 3005578 | PMCID | -N/A- |
Phenoxybenzenes and phenoxypyridines were prepared and tested for the effect of substituents on antipicornavirus activity. The most active compound, 2-(3,4-dichlorophenoxy)-5-nitrobenzonitrile (8), demonstrated broad-spectrum antipicornavirus activity. Compound 8 and several analogues each given orally prior to and during infection protected mice against an otherwise lethal challenge with coxsackievirus A21.