| Title | The impact of continuous positive airway pressure on heart rate variability in obstructive sleep apnea patients during sleep: A meta-analysis. | ||
| Author | Guo, Wenjia; Lv, Tingting; She, Fei; Miao, Guobin; Liu, Yuanwei; He, Rong; Xue, Yajun; Nu, Nang Kham; Yang, Jing; Li, Kun; Zhang, Ping | ||
| Journal | Heart Lung | Publication Year/Month | 2018-Sep-Oct |
| PMID | 30031552 | PMCID | -N/A- |
| Affiliation + expend | 1.School of Clinical Medicine, Tsinghua University, NO.1, Tsinghua Yuan, Haidian District, Beijing, 100084, China. | ||
BACKGROUND: Heart rate variability (HRV), modulated by cardiac autonomic function, is impaired in obstructive sleep apnea (OSA). However, the effect of continuous positive airway pressure (CPAP) on HRV is debated. OBJECTIVES: To investigate the associations between CPAP and HRV in OSA. METHODS: Based on literature from five databases published through August 2017, we performed a meta-analysis of cohort studies of OSA treated with CPAP. The change of low-frequency band (LF), high-frequency band (HF) and the ratio between LF and HF (LHR) were analyzed. RESULTS: Eleven studies were included. Decreased LF (SMD = -0.32, 95%CI: -0.62,-0.01; P = 0.043) and HF (SMD = -0.51, 95%CI: -0.95, -0.08, P = 0.020) were shown while measured on CPAP. When measured off CPAP, HF was increased remarkably (SMD: 0.31, 95%CI: 0.02, 0.60, P = 0.034). CONCLUSIONS: CPAP can improve autonomic activity, which might be one mechanism to reduce the risk of cardiovascular diseases in OSA.